Fresh (PHresh). Less than 1-2 years since publication

Isolated pulmonary valve endocarditis in a 7-year-old Nigerian girl: a case report

Ayobami Oyetunji Alabi, Bukola Adetutu Sayomi, Olanike Taye Oladibu, Mayowa Mary Adetoye, Nicholas Aderinto, Adeseye Abiodun AkintundeLadoke Akintola University of Technology (LAUTECH) Teaching Hospital. Nigeria Journal of Medical Case ReportsJ Med Case Rep 2025; 19: DOI: 10.1186/s13256-025-05241-y AbstractBackground: Right-sided infective endocarditis is a rare clinical entity, with isolated pulmonary valve infective endocarditis being extremely uncommon. Infective endocarditis […]

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Deciphering epigenetic control of Notch signaling in persistent pulmonary hypertension of the newborn

Matthew D. Durbin, David G. Tingay, Kok Lim KuaIndiana University School of Medicine. Murdoch Children’s Research Institute and University of Melbourne.United States and Australia Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04234-3 AbstractAbstract Not Available CategoryClass I. Persistent Pulmonary Hypertension of the NewbornAnimal Models of Pulmonary Vascular Disease and TherapyVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseGenetic

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Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial

Dalia A. Gomaa, Sahar M. El‑Haggar, Mohamed R. El‑Shanshory, Osama El‑Razaky, Dalia R. El‑AffyTanta University. Egypt Paediatric DrugsPaediatr Drugs 2025; DOI: 10.1007/s40272-025-00701-w AbstractBackground: Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can be identified by measuring tricuspid regurgitant jet velocity (TRJV). We looked for the possible

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial Read More »

Fetal therapy for congenital diaphragmatic hernia: past, present and future

Nimrah Abbasi, Tim Van Mieghem, Greg RyanMount Sinai Hospital and University of Toronto.Canada World Journal of Pediatric SurgeryWorld J Pediatr Surg 2025;DOI: 10.1136/wjps-2024-000835 AbstractCongenital diaphragmatic hernia (CDH) affects 1/2500-5000 infants and is associated with significant neonatal morbidity and mortality related to pulmonary hypoplasia and pulmonary hypertension. Current estimates of perinatal mortality are between 30-40%. With advances

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Usefulness of exercise stress echocardiography in a patient with unilateral pulmonary branch stenosis

Ryohei Yokoyama, Yoshihiko Kodama, Kazunari Takamura, Masako Takahashi, Miyo Tanaka, Nozomi Watanabe, Hiroshi MoritakeUniversity of Miyazaki.Japan Journal of Cardiology CasesJ Cardiol Cases 2025; 31: 155-157DOI: 10.1016/j.jccase.2025.02.003 AbstractExercise stress echocardiography (ESE) is a feasible and valuable tool for evaluating subclinical pulmonary hypertension (PH). However, its utility in patients with unilateral pulmonary branch stenosis remains unclear. We present

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Whole exome sequencing unravels genetic architecture and its clinical implications in pediatric pulmonary arterial hypertension

Dai-Ji Jiang, Yi-Jia Yang, Yu-Zhen Wang, Xu Zhang, Wen-Xiu, Chan, Ting-Ting Yu, Hao Chen, Hao Zhang, Yi Yan, Li-Jun FuShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine.China International Journal of CardiologyInt J Cardiol 2025; DOI: 10.1016/j.ijcard.2025.133515 AbstractBackground: Pulmonary arterial hypertension (PAH) is a severe disease with significant genetic predisposition.

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Predicting pulmonary hemodynamics in pediatric pulmonary arterial hypertension using cardiac magnetic resonance imaging and machine learning: an exploratory pilot study

Hung Chu, Rosaria J. Ferreira, Chantal Lokhorst, Johannes M. Douwes, Meindina G. Haarman, Tineke P. Willems, Rolf M.F. Berger, Mark-Jan PloegstraBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen. Frisius Medical Center Leeuwarden.Netherlands International Journal of Cardiovascular ImagingInt J Cardiovasc Imaging 2025; DOI: 10.1007/s10554-025-03434-6 AbstractPurpose: Pulmonary arterial hypertension (PAH) significantly affects the pulmonary vasculature, requiring

Predicting pulmonary hemodynamics in pediatric pulmonary arterial hypertension using cardiac magnetic resonance imaging and machine learning: an exploratory pilot study Read More »

Severe Early-Onset Pulmonary Hypertension in a Six-Month-Old With Down Syndrome and Isolated Secundum Atrial Septal Defect

Fatima Abeer, Aasim Ayaz Wani, Bisma Javid, Aisha Mahmood, Gazala AndleebGovernment Medical College, Srinagar. National Institute of Technology Srinagar. India CureusCureus 2025; 17: DOI: 10.7759/cureus.84019 AbstractInfants with Down syndrome (trisomy 21) commonly present with congenital heart defects and immune dysregulation, significantly increasing the risk of early-onset pulmonary arterial hypertension (PAH). Although secundum atrial septal defects (ASDs)

Severe Early-Onset Pulmonary Hypertension in a Six-Month-Old With Down Syndrome and Isolated Secundum Atrial Septal Defect Read More »

Oxygen Saturation Targeting in the Neonatal Intensive Care Unit

Faeq Almudares, Bheru Gandhi, Jonathan Davies, Xanthi Couroucli, Natalie Villafranco, Nidhy Paulose Varghese, Milenka Cuevas Guaman, Charleta Guillory, Binoy ShivannaBaylor College of Medicine.United States Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14113975 AbstractOxygen (O2) is vital for cellular development, function, proliferation, and repair, underscoring its critical role in organogenesis. Both hypoxia (reduced tissue O2)

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Case Report: Pulmonary arterial hypertension in children caused by a new mutation in the BMPR2 gene

Ting Tang, Shuqi Wu, Chang Peng, Li WangGuizhou Children’s Hospital and Affiliated Hospital of Zunyi Medical University.China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1572733 AbstractPulmonary arterial hypertension (PAH) is a rare and severe condition that has been linked to hereditary factors. Mutations in the gene encoding bone morphogenetic protein receptor 2 (BMPR2) have been identified

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