Fresh (PHresh). Less than 1-2 years since publication

Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients

Gabriel F. Diaz, Carlos E. Diaz‐Castrillon, Alicia Marquez Garcia, Rachel K. Hopper, Vinicio de J. PerezUniversidad Nacional De Colombia. University of Pittsburgh. Centro Policlínico Del Olaya and Clínica De La Mujer. Stanford University School of Medicine. Columbia and United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70017 AbstractPulmonary hypertension (PH) at high altitudes presents unique characteristics […]

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Unilateral pulmonary vein atresia

Y. Wang, Y. Tang, L. Sun, X. Zhang, Y. Liu, S. Xu, Y. Su, L. Zhang, X. Tang, H. Yang, Yuelin ShenHenan Children’s Hospital, Zhengzhou Children’s Hospital and Zhengzhou University. Capital Medical University and National Center for Children’s Health. Children’s Hospital of Xinjang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children’s Hospital and Seventh People’s

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Unusual Pulmonary Manifestation in a Child With Congenital Mitral Stenosis: A Case Report

Ola Alhalabi, Ahmed Abushahin, Atqah AbdulwahabSidra Medicine.Qatar CureusCureus 2025; 17: DOI: 10.7759/cureus.80575 AbstractCongenital mitral valve stenosis (MVS) in children is usually isolated. However, it is, in rare cases, associated with secondary pulmonary hemosiderosis. It is hypothesized that secondary pulmonary hemosiderosis results from chronic pulmonary venous congestion and repeated microvascular hemorrhage due to elevated left atrial pressure.

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Right cardiac failure and pulmonary hypertension secondary to tonsil hypertrophy in a 3-year-old boy: a case report

Mehdi Berrajaa, Abdeladim Babakhouya, Mohamed El MinaouiSouss-Massa University Hospital and University Ibn Zohr. Mohammed VI University Hospital.Morocco PanAfrican Medical JournalPan Afr Med J 2025; DOI: 10.11604/pamj.2025.50.2.39678 AbstractIn children, the prevalence of obstructive sleep apnoea syndrome (OSAS) is 2 to 3%. Pulmonary hypertension-related OSAS in the context of tonsil hypertrophy is a well-documented phenomenon. However, cases combining

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Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension

Christian Westöö, Ayse Ceren Mutgan, Oscar van der Have, Timothy J. Mead, Salaheldin Ahmed, Elna Lampei, Christopher D. Koch, Christian Norvik, Anders Aspberg, Martin Bech, Niccolò Peruzzi, Hans Brunnström, Grazyna Kwapiszewska, Göran Rådegran, Suneel S. Apte, Karin Tran-LundmarkLund University. Medical University of Graz. Skåne University Hospital. Cleveland Clinic Lerner Research Institute. Case Western Reserve University. University Hospitals Rainbow Babies & Children’s Hospital. Helsingborg Hospital. Sanford School of Medicine and University of South Dakota. German Center for Lung Research Sweden, Austria, United States

Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension Read More »

Recurrence of Primary Sclerosing Cholangitis After Pediatric Liver Transplantation: A Single-Center, Retrospective Study in Japan

Athaya Vorasittha, Seisuke Sakamoto, Yusuke Yanagi, Kazuki Degawa, Hirotaka Kato, Tasuku Kodama, Ryuji Komine, Masaki Yamada, Hajime Uchida, Akinari Fukuda, Chiduko Haga, Takako Yoshioka, Mureo KasaharaNational Center for Child Health and Development. Japan Pediatric TransplantationPediatr Transplant 2025; 29: DOI: 10.1111/petr.70078 AbstractAim: Liver transplantation (LT) is a well-accepted treatment for primary sclerosing cholangitis (PSC) with generally good outcomes,

Recurrence of Primary Sclerosing Cholangitis After Pediatric Liver Transplantation: A Single-Center, Retrospective Study in Japan Read More »

Characteristics and outcomes of preterm infants with early pulmonary hypertension

Rachel Mullaly, Aisling Smith, Claire Murphy, Seán Armstrong, Orla Franklin, Naomi McCallion, Afif EL-KhuffashRotunda Hospital. Royal College of Surgeons in Ireland. Children’s Health Ireland at Crumlin.Ireland Journal of PerinatologyJ Perinatol 2025; DOI: 10.1038/s41372-025-02295-0 AbstractObjective: This study investigates incidence, outcomes and echocardiographic characteristics of preterm infants with early pulmonary hypertension (PH) compared to those without.Study design: A prospective observational

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The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway

Youpeng Jin, Fei Mao, Xuehui Wang, Jie Zhang, Yanting Gao, Youfei FanShandong Provincial Hospital, First Affiliated Hospital and Shandong First Medical University.China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-97627-7 AbstractPulmonary arterial hypertension (PAH) is a severe and progressive disease with hallmarks of pulmonary vascular remodeling and bone morphogenetic protein receptor 2 (BMPR2) mutation. Recent studies indicate

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Paediatric Lung Transplantation for Childhood Interstitial Lung Disease: Indications and Outcome

Hendrik Schneider, Fabio Ius, Carsten Müller, Jawad Salman, Katharina Schütz, Harald Köditz, Katja, Nickel, Gesine Hansen, Dmitry Bobylev, Nicolaus, Schwerk, Julia CarlensHannover Medical School. Germany Journal of Heart and Lung TransplantationJ Heart Lung Transplant 2025; DOI: 10.1016/j.healun.2025.04.001 AbstractBackground: Childhood interstitial lung disease (chILD) is heterogeneous, associated with significant morbidity and can cause organ failure. In these cases,

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Pulmonary hypertension in pediatrics: from clinical suspicion to management

Julie Wacker, Maurice BeghettiGeneva University Hospitals. Switzerland European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06099-4 AbstractPediatric pulmonary hypertension differs from adult pulmonary hypertension in many ways, including multifactorial etiologies and comorbidities that can impact diagnosis, response to therapy, and outcome. The main etiologies of pediatric PH are idiopathic pulmonary arterial hypertension (PAH), PAH associated

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