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Whole blood and tissue miRNA expression profiles in children with congenital heart disease-associated pulmonary arterial hypertension

Halis Yilmaz, Deniz Elcik, Aydin Tuncay, Ozge Pamukcu, Serpil Taheri, Fatma Sena Topcu, Ismail Duzgun, Nazmi Narin, Ecmel Mehmetbeyoglu Duman, Begum Er, Gökmen ZararsizErciyes University School of Medicine and Erciyes University.Turkey Scientific ReportsSci Rep 2026; DOI: 10.1038/s41598-026-61056-x AbstractPulmonary arterial hypertension (PAH) is a major complication of congenital heart disease (CHD) with left-to-right shunts. Early identification of […]

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Perinatal survival and long-term neurodevelopmental outcomes of congenital chylothorax

Hideyuki Hawaka, Tomoyuki Shimokaze, Jun Shibasaki, Hiromi Nagase, Tomoko Saito, Hiroshi Ishikawa, Katsuaki ToyoshimaKanagawa Children’s Medical Center. Hiroshima City Hiroshima Citizens Hospital. Japan Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05271-2 AbstractBackground: Congenital chylothorax carries a poor prognosis, particularly with delivery at <32 weeks. Survival outcomes under consistent management prioritizing pregnancy prolongation despite worsening hydrops, as well as long-term

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Inhibition of thrombospondin-1 signaling prevents experimental bronchopulmonary dysplasia

Chantal Gaudet, Kathrine L. Daniel, Sophie Holcik, Ali Hamraghani, Behzad Yeganeh, Robert P JankovChildren’s Hospital of Eastern Ontario. University of Ottawa. Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00090.2026 AbstractBronchopulmonary dysplasia (BPD) is a neonatal lung injury characterized by inflammation, and alveolar and vascular hypoplasia

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Perioperative anesthetic management in pediatric heart transplantation: a single-center descriptive study involving 27 patients

Ya-fei Cheng, Cong-li Meng, Yi-ru Wang, Lin Chen, Ya-qun Ma, Wen-zhi Guo, Hang GuoSeventh Medical Center to Chinese PLA General Hospital. Southern Medical University.China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1842135 AbstractBackground: Orthotopic heart transplantation is the standard treatment for pediatric end-stage heart disease. Due to the wide age range and high physiological heterogeneity among pediatric

Perioperative anesthetic management in pediatric heart transplantation: a single-center descriptive study involving 27 patients Read More »

Repair of Sinus Venosus Atrial Septal Defect in 2 Patients With Severe Pulmonary Arterial Hypertension

Ryo Sakuma, Gareth Morgan, Elizabeth Yeung, Benjamin S. Frank, Charles Simpkin, Dunbar IvyUniversity of Colorado School of Medicine.United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70285 AbstractPretreatment with targeted pulmonary arterial hypertension (PAH) therapy in adults with unrepaired atrial septal defects (ASDs) has been increasingly reported as a means to improve pulmonary hemodynamics and expand candidacy

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JCS/JPCPHS 2025 Guideline on Pulmonary Hypertension and Pulmonary Embolism/Deep Vein Thrombosis

Yuichi Tamura, Kenya Kusunose, Yugo Yamashita, Teiji Akagi, Masanori Atsukawa, Yoshihiro Fukumoto, Ayumi Goda, Shinya Goto, Masaru Hatano, Masataka Ikeda, Keiichi Ishida, Masaharu Kataoka, Masataka Kuwana, Hiromi Matsubara, Makoto Mo, Tetsutaro Nagaoka, Takeshi Ogo, Yoshinori Okada, Seiichiro Sakao, Hirofumi Sawada, Toshiro Shinke, Nobuhiro Tanabe, Norikazu Yamada, Hiroyuki Yamagishi, Shingo Yano, Kohtaro Abe, Shiro Adachi, Kazuya

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Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure: The RAFT Clinical Trial

Jena L. Miller, Ahmet A. Baschat, Anthony Johnson, Yair J. Blumenfeld, Mauro H. Schenone, Juliana S. Gebb, Julie S. Moldenhauer, Michael V. Zaretsky, Ramen H. Chmait, Juan M. Gonzalez, Russel S. Miller, Eyal Krispin, Alireza Shamshirsaz, Katherine H. Bligard, Amanda M. Kalan, Magdalena Sanz Cortes, Anita J. Moon-Grady, Ellen Bendel-Stenzel, Shina Menon, Cynthia Wong, Paul

Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure: The RAFT Clinical Trial Read More »

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya UchidaUniversity of Shizuoka. Seirei Hamamatsu General Hospital. Hamamatsu University School of Medicine.Japan British Journal of Clinical PharmacologyBr J Clin Pharmacol 2026; DOI: 10.1002/bcp.70676 AbstractAims: Pulmonary arterial hypertension (PAH) is a

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs Read More »

Late presentation of alveolar capillary dysplasia with misalignment of pulmonary veins presenting as refractory pulmonary hypertension in infancy

Tamer Abusido, Saleh Alshaibi, Abdullah Aldraihem, Abdulmajeed AlfadhelAbdullah Specialized Children Hospital and King Abdulaziz Medical City. King Saud Bin Abdulaziz University for Health Sciences. King Abdullah International Medical Research Center. Saudi Arabia Respiratory Medicine Case ReportsRespir Med Case Rep 2026; 62: DOI: 10.1016/j.rmcr.2026.102456 AbstractBackground: Alveolar capillary dysplasia with misalignment of the pulmonary veins (ACD-MPV) is a rare

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Long-Term Complications of Sickle Cell Disease

Luisanna M. Sánchez, Ajibike Lapite, Alicia Chang, Titilope A. FasipeIndiana Hemophilia and Thrombosis Center. Baylor College of Medicine and exas Children’s Hospital. University of Texas at Austin and Dell Children’s Hospital. United States Pediatrics in ReviewPediatr Rev 2026; 47: 394-403DOI: 10.1542/pir.2024-006446 AbstractSCD is a prevalent genetic disorder marked by chronic complications that impact quality of life

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