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The Burden of Prior Authorizations for Pediatric Pulmonary Hypertension Medications: A Quantitative Assessment

Delphine Yung, Anne Davis, Kelly MerrillSeattle Children’s Hospital and University of Washington School of Medicine.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70221 AbstractThis study quantified prior authorization (PA)-insurance-required approval-burden for pediatric pulmonary hypertension (PH) at an accredited center. Among 53 patients, 72% of 283 prescriptions between 2021 and 2023 required PA, with non-FDA-approved medications showing […]

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Transcatheter Management of Pulmonary Vein Stenosis in Children

Connie Choi, Ryan CallahanSeattle Children’s Hospital. Children’s Hospital of Philadelphia. United States Pediatric CardiologyPediatr Cardiol 2025; DOI: 10.1007/s00246-025-04130-x AbstractPediatric intraluminal pulmonary vein stenosis (PVS) is a challenging condition where the diagnosis is confirmed via cardiac catheterization. The patient population is complex with inherent hemodynamic vulnerabilities, and the high rate of restenosis necessitates recurrent, technically demanding transcatheter

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[Pediatric pneumological aspects in the care of children with Down Syndrome]

Hans Fuchs, Lennart Gunst, Anke Wendt, Sebastian Becker, Ruth Margarethe Grychtol, Dejan Vlajnic, Dorit Aschmann-Muehlhans, Christiane Wuerfel, Mathis Steindor, Svea Muehlberg, Florian StehlingAlbert-Ludwigs-Universität Freiburg. Charité Universitätsmedizin Berlin. Darmstädter Kinderkliniken Prinzessin Margaret. Medizinische Hochschule Hannover. Klinikum Leverkusen. Kinderkrankenhaus St. Marien. Technische Universität Dresden. Heinrich-Heine-Universität Düsseldorf. Universitäts-Kinderspital Zürich. Universität Duisburg-Essen.Germany and Switzerland Klinische PädiatrieKlin Padiatr 2025; DOI: 10.1055/a-2748-4649

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AI learning for pediatric right ventricular assessment: development and validation across multiple centers

Charitha Reddy, Yi Yan, Min Qiu, Yi Tang, Bo Jin, Zhi Han, Yuhang Li, Sihan Zhou, Qiming Tang, Huan Xiao, Shu Yang, Qigui Wen, Lan-Ping Wu, Li-Jun Fu, Ze-Yu Jing, Yi-Jia Yang, Yu-Qi Zhang, Naoto Ozawa, Takumi Ichikawa, Ellen Ling, Ronald J. Wong, Nima Aghaeepour, Brice Gaudilliere, Martin S. Angst, Karl G. Sylvester, Harvey J.

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New Insights: P.I.G in Preterm Infants With Isolated PDA and Severe Pulmonary Hypertension

Nadya Ben Fadel, Elham Almoli, Joseph de Nanassy, Sally MashallyChildren’s Hospital of Eastern Ontario and University of Ottawa. Canada Case Reports in PediatricsCase Rep Pediatr 2025; DOI: 10.1155/crpe/6268296 AbstractWe present a case of a premature infant who had a persistent patent ductus arteriosus (PDA) and subsequently developed severe pulmonary hypertension (PHT) and respiratory failure. A lung

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Paediatric pulmonary arterial hypertension following congenital heart defect repair: Enhanced risk stratification and outcomes in a national cohort

Andrew Constantine, Konstantinos Dimopoulos, Robin Condliffe, Paul Clift, Katrijn Jansen, S. John Wort, Grace Chaplin, Kaushiga Krishnathasan, Rami Dhillon, Joydeep Mookerjee, W. Brodie Knight, Caroline B. Jones, Maria N. Velasco Forte, Dirk Wilson, Helen Michael, Alberto Mendoza Soto, Carlos Labrandero, Alejandro Rodríguez Ogando, Antonio Moreno Galdó, Inmaculada Guillén Rodríguez, Lina M. Caicedo Cuenca, Francesca Perin,

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Reversible pulmonary hypertension in a patient diagnosed with scurvy

Gregory Berra, Léon Genecand, Anais Juillet, Jean-François Deux, Paco Prada, Hajo Müller, Marco Roffi, Maurice BeghettiGeneva University Hospitals. Switzerland British Medical Journal Case ReportsBMJ Case Rep 2025; 18: DOI: 10.1136/bcr-2025-266143 AbstractThis case report describes a woman in her late 50s with reversible pulmonary hypertension (PH) due to scurvy, a rare vitamin C (ascorbic acid) deficiency in

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Hepatic vein-derived factors may affect pulmonary arteriovenous malformations after single ventricle palliation by modulating vascular cell behavior

Laura Yuriko González-Teshima, Keisuke Hakamada, Kozue Murata, Reiko Nakagawa, Shiro Baba, Yujiro Ide, Maiko Okamura, Akio Ikai, Tadashi Ikeda, Kenji Minatoya, Masaya Hagiwara, Masaya Ikegawa, Hidetoshi MasumotoKyoto University Graduate School of Medicine. RIKEN Center for Biosystems Dynamics Research. Doshisha University. Shizuoka General Hospital. Japan Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-25523-1 AbstractPulmonary arteriovenous malformations (PAVM) are

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Meta-Analysis of Differential Gene Expression in Idiopathic Pulmonary Arterial Hypertension

Andy P. Huang, Sarah Voskamp, Ameneh A. Ebadi, Jennifer L. Liedel, Jennifer S. Nelson, Joseph KuruvillaUniversity of Central Florida. Nemours Children’s Hospital. United States Cardiovascular PathologyCardiovasc Pathol 2025;  DOI: 10.1016/j.carpath.2025.107805 AbstractBackground: Idiopathic pulmonary arterial hypertension (IPAH) is a subtype of pulmonary arterial hypertension and impacts both children and adults. IPAH has overall poor survival, highlighting the importance

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Use of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors in Pulmonary Hypertension

Benoit Aguado, Grégoire Ruffenach, Thomas Lacoste-Palasset, Agnes Görlach, Marianne Riou, Mathieu Gourmelon, Fabrice Bauer, Marc Humbert, Valerie Schini-Kerth, Jean-Luc Vachiéry, David Montani, Fabrice AntignyUniversité Paris-Saclay and French National Institute for Health and Medical Research. Hôpital Bicêtre and Hôpital Marie Lannelongue. Technical University Munich and German Centre for Cardiovascular Research. Nouvel Hôpital Civil and University Hospital

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