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Clinical Factors Associated with Ventilator-Free Days in Newborns with Persistent Pulmonary Hypertension of the Newborn: A Retrospective Cohort Study in Thailand

Sirichan Larpnarongchai, Gunlawadee Maneenil, Anucha Thatrimontrichai Supaporn Dissaneevate, Manapat Praditaukrit, Pattima PakhathirathienPrince of Songkla University.Thailand Journal of Clinical MedicineJ Clin Med 2026; 15: DOI: 10.3390/jcm15114377 AbstractBackground/Objectives: Ventilator-free days (VFDs) are a useful composite measure to assess both survival and duration of mechanical ventilation in critically ill patients. This study aimed to determine the factors associated with […]

Clinical Factors Associated with Ventilator-Free Days in Newborns with Persistent Pulmonary Hypertension of the Newborn: A Retrospective Cohort Study in Thailand Read More »

Contemporary Endothelial Genome Editing Technologies: Towards Precision Genetic Medicine for Vascular Diseases

You-Yang Zhou, Colin E. EvansAnn and Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. United States International Journal of Molecular SciencesInt J Mol Sci 2026; 27: DOI: 10.3390/ijms27115100 AbstractEndothelial dysfunction is a key characteristic of many diseases, including atherosclerosis, hypertension, heart failure, stroke, cancer, acute respiratory distress syndrome (ARDS), peripheral

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Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant

Jennifer A. Wambach, F. Sessions Cole, Lawrence M. NogeeWashington University School of Medicine and St. Louis Children’s Hospital. Johns Hopkins University. United States Clinics in PerinatologyClin Perinatol 2026; 53: 381-401DOI: 10.1016/j.clp.2026.03.003 AbstractHypoxemic respiratory failure is a common reason for admission to the neonatal intensive care unit for term and late preterm infants. Some infants have rare

Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant Read More »

Management of Hypoxemic Respiratory Failure in the Newborn During Therapeutic Hypothermia

Paulina Hume, Luna Khanal, Satyan Lakshminrusimha, Deepika SankaranUniversity of California, Davis.United States Clinics in PerinatologyClin Perinatol 2026; 53: 317-332DOI: 10.1016/j.clp.2026.02.008 AbstractTherapeutic hypothermia (TH) is the gold standard for the management of hypoxic ischemic encephalopathy (HIE) in newborns. Both hypoxia and TH may contribute to an increase in pulmonary vascular resistance (PVR), resulting in persistent pulmonary hypertension

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Advances in the Management of Persistent Pulmonary Hypertension of the Newborn

Emily Mooers, Satyan Lakshiminrusimha, G. Ganesh KonduriMedical College of Wisconsin and Children’s Wisconsin. University of California and UC Davis Children’s Hospital.United States Clinics in PerinatologyClin Perinatol 2026; 53: 297-316DOI: 10.1016/j.clp.2026.02.003 AbstractThis article details an integrated approach to optimize management strategies for hypoxemic respiratory failure and hemodynamic instability in persistent pulmonary hypertension of the newborn (PPHN). Even

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Respiratory Management for the Infant with Congenital Diaphragmatic Hernia

Michelle J. Yang, Matthew Douglass, Ryan J. Carpenter, Bradley A. YoderUniversity of Utah School of Medicine and Primary Children’s Hospital.United States Clinics in PerinatologyClin Perinatol 2026; 53: 277-295DOI: 10.1016/j.clp.2026.02.002 AbstractCongenital diaphragmatic hernia (CDH) is a complex neonatal condition characterized by pulmonary hypoplasia and pulmonary hypertension, requiring specialized ventilatory management from birth through postoperative care. This article

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Association between hepatic vein Doppler and echocardiographic diastolic indices with invasively measured right ventricular filling pressures in pediatric pulmonary arterial hypertension

Tessa Palmeri, Wei Hui, Charles T. Simpkin, Andreea Dragulescu, Luc Mertens, Dunbar Ivy, Dale Burkett, Mark FriedbergHospital for Sick Children. University of Colorado Medical Campus.Canada and United States International Journal of CardiologyInt J Cardiol 2026; DOI: 10.1016/j.ijcard.2026.134619 AbstractBackground: Increased right ventricular filling pressures (RVFP) are associated with increased mortality risk in children with pulmonary arterial hypertension (PAH).

Association between hepatic vein Doppler and echocardiographic diastolic indices with invasively measured right ventricular filling pressures in pediatric pulmonary arterial hypertension Read More »

Non-invasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension

John D. Dauz, Bahram Mirani, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergHospital for Sick Children and University of Toronto. Ted Rogers Centre for Heart Research. Canada American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2026; DOI: 10.1152/ajpheart.00459.2026 AbstractMain pulmonary artery (MPA) stiffening increases right ventricular (RV)

Non-invasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension Read More »

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia

Amed Soliz, Jorge SolizFlorida International University and Memorial Regional Hospital. Institute Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) and Université Laval. Altitude Baby Association. United States and Canada Respiratory Physiology and NeurobiologyRespir Physiol Neurobiol 2026;DOI: 10.1016/j.resp.2026.104609 AbstractHigh altitude exposes the human fetus and newborn to chronic hypobaric hypoxia, markedly reducing oxygen availability during critical

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia Read More »

A Biomimetic Miniaturized In Vitro Model to Target Early Markers of Neonatal Pulmonary Vascular Injury

Motaharehsadat Heydarian, Ali Doryab, Juan Henao, Benjamin Schubert, Otmar Schmid, Anne HilgendorffHelmholtz Zentrum München and German Lung Research Center. University of Cambridge. University Hospital Ludwig-Maximilian University. Carl von Ossietzky University.Germany and United Kingdom American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00002.2026 AbstractPulmonary vascular disease (PVD) is

A Biomimetic Miniaturized In Vitro Model to Target Early Markers of Neonatal Pulmonary Vascular Injury Read More »

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