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The effects of standardized intravenous treprostinil in pulmonary arterial hypertension patients after total cavo-pulmonary connection procedure

Xiaofeng Wang, Shilin Wang, Ruihuan Shen, Zhongyuan Lu, Xu WangFuwai Hospital, Beijing Hospital and Chinese Academy of Medical Sciences and Peking Union Medical College.China European Journal of Medical ResearchEur J Med Res 2024; 29: DOI: 10.1186/s40001-024-02077-y AbstractObjective: Total cavo-pulmonary connection (TCPC) is a palliative treatment for single ventricular malformations. For high-risk patients (preoperative mean pulmonary arterial pressure, […]

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A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha TalatiVanderbilt University Medical Center and Vanderbilt University.United States Frontiers in MedicineFront Med 2024; DOI: 10.3389/fmed.2024.1387195 AbstractBackground: In PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma Read More »

Association of Right Ventricular Dysfunction with Risk of Neurodevelopmental Impairment in Infants with Pulmonary Hypertension

Rossana Romero Orozco, Tazuddin A. Mohammed, Kerri Carter, Shaaron Brown, Stephen Miller, Roy T. Sabo, Meredith Campbell Joseph, Uyen Truong, Megha Nair, Victoria Anderson, Jie Xu, Judith A. Voynow, Karen D. Hendricks-MuñozChildren’s Hospital of Richmond at VCU and Virginia Commonwealth University School of Medicine. UF Health Shands Children’s Hospital and University of Florida.  Children’s National

Association of Right Ventricular Dysfunction with Risk of Neurodevelopmental Impairment in Infants with Pulmonary Hypertension Read More »

The Mitochondrial Redistribution of eNOS is Regulated by AKT1 and Dimer Status

Xutong Sun, Santiago Moreno, Manivannan Yegambaram, Qing Lu, Marissa D. Pokharel, Jason T. Boehme, Sanjeev A. Datar, Sayrabh Aggarwal, Ting Wang, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of California San Francisco. United States Nitric OxideNitric Oxide 2024; DOI: 10.1016/j.niox.2024.09.009 AbstractPreviously, we have shown that endothelial nitric-oxide synthase (eNOS) dimer levels directly correlate with

The Mitochondrial Redistribution of eNOS is Regulated by AKT1 and Dimer Status Read More »

Navigating Pediatric Cor Pulmonale: A Comprehensive Review of Diagnosis and Management

Yash Thakur, Revat J. Meshram, Amar TaksandeJawaharlal Nehru Medical College and Datta Meghe Institute of Higher Education and Research.India CureusCureus 2024; 16: DOI: 10.7759/cureus.67782 AbstractPediatric cor pulmonale, characterized by right ventricular dysfunction due to chronic pulmonary hypertension, presents significant diagnostic and management challenges. This comprehensive review delves into this complex condition’s etiology, clinical presentation, diagnostic strategies,

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GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang ZhaoNorthwestern University Feinberg School of Medicine.United States Journal of Clinical Investigation InsightJCI Insight 2024; DOI: 10.1172/jci.insight.177926 AbstractPulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding GCN2, General control

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension Read More »

Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia

Caitlin V. Lewis, Anastacia M. Garcia, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Thi-Tina Nguyen, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Physiological GenomicsPhysiol Genomics 2024; DOI: 10.1152/physiolgenomics.00078.2024 AbstractThe extracellular isoform of superoxide dismutase (SOD3) is decreased in patients and animals with pulmonary

Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia Read More »

Variation and significance of serum microRNA-21 level in pediatric pulmonary artery hypertension associated with congenital heart disease

Yanming Shen, Dongshan Liao, Wenlin Shangguan, Liangwan ChenFujian Medical University. Union Hospital. Fuzhou Changle District People’s Hospital.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2024; DOI: 10.3389/fcvm.2024.1424679 AbstractObjective: This study strives to the variation and significance of microRNA-21 (miR-21) in children with congenital heart disease (CHD)-related pulmonary artery hypertension (PAH).Methods: Children with CHD (n = 179) were selected as subjects,

Variation and significance of serum microRNA-21 level in pediatric pulmonary artery hypertension associated with congenital heart disease Read More »

Impact of general anesthesia on the echocardiographic assessment of right ventricular function in pediatric patients with pulmonary arterial hypertension

Charles T. Simpkin, Billy J. McElroy, Gareth J. Morgan, David Dunbar Ivy, Dale A. Burkett, Mark D. Twite, Benjamin S. FrankUniversity of Colorado Denver. United States Pulmonary CirculationPulm Circ 2024; DOI: 10.1002/pul2.12435 AbstractOne of the great diagnostic challenges for children with pulmonary arterial hypertension is the need for general anesthesia (GA) to enable successful right heart

Impact of general anesthesia on the echocardiographic assessment of right ventricular function in pediatric patients with pulmonary arterial hypertension Read More »

Association between pertactin-producing Bordetella pertussis and fulminant pertussis in infants: a multicenter study in France, 2008-2019

Pauline Leroux, Soraya Matczak, Valérie Bouchez, Stevenn Volant, Antoine Ouziel, Elise Launay, Albert Faye, Valérie Rabier, Jean Sarlangue, Eric Jeziorski, Zoha Maakaroun-Vermesse, Fouad Madhi, Didier Pinquier, Mathie Lorrot, Marie Pouletty, Aymeric Cantais, Etienne Javouhey, Fatima Aït Belghiti, Sophie Guillot, Carla Rodrigues, Sylvain Brisse, Jérémie F. Cohen, Julie ToubianaUniversité Paris Cité. Hospices Civils de Lyon. University

Association between pertactin-producing Bordetella pertussis and fulminant pertussis in infants: a multicenter study in France, 2008-2019 Read More »

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