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Are Early, Frequent Echocardiograms Necessary to Improve Outcomes of Neonates with Congenital Diaphragmatic Hernia?

Michelle J. Yang, Ryan J. Carpenter, Katie W. Russell, Stephen J. Fenton, Christian C. Yost, Bradley A. YoderUniversity of Utah School of Medicine and Primary Children’s Hospital.United States Journal of PediatricsJ Pediatr 2025; DOI: 10.1016/j.jpeds.2025.114510 AbstractObjective: To determine if timing of first postnatal echocardiogram (ECHO), early vs delayed, affects the use of extracorporeal membrane oxygenation (ECMO) and […]

Are Early, Frequent Echocardiograms Necessary to Improve Outcomes of Neonates with Congenital Diaphragmatic Hernia? Read More »

Valsartan to Prevent Acquired Pulmonary Vein Stenosis in Pediatric Patients After Total Anomalous Pulmonary Venous Connection Surgery

Jin Shentu, Mingjie Zhang, Zhuoming Xu, Chen Wen, Hao Zhang, Zhongqun Zhu, Huiwen Chen, Guocheng ShiShanghai Children’s Medical Center and Shanghai Jiao Tong University. China Journal of the American Heart AssociationJ Am Heart Assoc 2025; 14: DOI: 10.1161/JAHA.124.036911 AbstractBackground: Recurrent pulmonary vein stenosis (PVS) following surgical repair of total anomalous pulmonary venous connection is associated with poor prognosis. Preclinical studies have shown that use of an angiotensin receptor blocker can attenuate intimal

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Inhaled Epoprostenol in Children With Pediatric Acute Respiratory Distress Syndrome: A Single-Center Retrospective Study

Eleanor J. Scalone, Alan G. Woodruff, Amit K. Saha, John M. Wright, Kristopher L. Dixon, Andora L. Bass, Michael J. Walsh, Michael C. McCroryWake Forest University School of Medicine. University of Pennsylvania Perelman School of Medicine.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71010 AbstractBackground: Inhaled epoprostenol (iEpo) may improve oxygenation in adults with hypoxic respiratory failure,

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Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model

Akash Gupta, Nahla Zaghloul, Senthil Kumar Thulasingam, Ian Richard Robbins, Geetanjali Gupta, Jad Bader, Joe Gn Garcia, Mohamed AhmedUniversity of Arizona. University of Florida. United States Translational ResearchTransl Res 2025; DOI: 10.1016/j.trsl.2025.02.001 AbstractChAT-expressing T cells represent ∼0.01% of total circulating T lymphocytes in adult wild-type mice. However, we previously reported that systemic infusion of ChAT+ve Jurkat

Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model Read More »

Case Report: severe pulmonary hypertension in a child with micronutrient deficiency

Laure Pache-Wannaz, Cristiana Voicu, Laurence Boillat, Nicole SekarskiLausanne University Hospital and University of Lausanne.Switzerland Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1478889 AbstractWe describe the rare case of a previously healthy seven year-old boy, with an acute clinical onset of severe pulmonary hypertension. He recovered rapidly after vitamin supplementation. Patient history showed a highly selective food

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Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin-Dependent Mechanism

Jingyuan Chen, Xinping Chen, Vineet Agrawal, Christy S. Moore, Tom Blackwell, Nivedita Rathaur, Santhi Gladson, Anandharajan Rathinasabapathy, Anna Hemnes, Eric Austin, James WestVanderbilt University Medical Center. Second Xiangya Hospital of Central South University. Wistar Institute.United States and China Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70054 AbstractFemale sex increases risk of Group I pulmonary arterial hypertension by

Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin-Dependent Mechanism Read More »

Screening For Critical Congenital Heart Disease Using Pulse-Oximetry, The First Egyptian Multicentre Study

Mohammad Eltahlawi, Alaa Elghamrawy, Maiy Hamdy Elsayed, Mona Hafez, Asmaa Elmesiry, Mohamed Bayomy, Hani Adel, Mahmoud Elfayoumy, Sahbaa Hafez, Said Morsy, Mahmoud Elhady, Baher Nashy, Mohamed Abo ElelaZagazig University. Ministry of Health. Ain Shams University. Mansoura University. Tanta University. Alazhar University. Alexandria University. Benha University. Assuit University.Egypt Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125000289 AbstractBackground: Congenital

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Web server-based deep learning-driven predictive models for respiratory toxicity of environmental chemicals: Mechanistic insights and interpretability

Na Li, Zhaoyang Chen, Wenhui Zhang, Yan Li, Xin Huang, Xiao LiFirst Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital. China Journal of Hazardous MaterialsJ Hazard Mater 2025; 489: DOI: 10.1016/j.jhazmat.2025.137575 AbstractRespiratory toxicity of chemicals is a common clinical and environmental health concern. Currently, most in silico prediction models for chemical respiratory

Web server-based deep learning-driven predictive models for respiratory toxicity of environmental chemicals: Mechanistic insights and interpretability Read More »

An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension

Ram Raj Prasad 1, Sushil Kumar 1, Hui Zhang 1, Min Li 1, Cheng-Jun Hu 2, Suzette Riddle 1, Brittany A McKeon 3, M G Frid 1, Konrad Hoetzenecker 4, Slaven Crnkovic 5, Grazyna Kwapiszewska 5, Rubin M Tuder 1, Kurt R Stenmark 1 University of Colorado Anschutz Medical Campus. Medical University of Vienna. Medical University of Graz.United States and Austria Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.184141 AbstractThe complement system is central to the innate immune response, playing

An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension Read More »

Bosentan as adjunctive therapy in neonates with congenital diaphragmatic hernia-associated pulmonary hypertension: a case series

Aster De Vadder, Lotte Lemloh, Bartolomeo Bo, Lennart Hale, Neil Patel, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn. Royal Hospital for Children. Germany and United Kingdom European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06019-6 AbstractCongenital diaphragmatic hernia (CDH)-associated pulmonary hypertension (PH) is associated with high morbidity and mortality. Pulmonary vasodilative management is challenging

Bosentan as adjunctive therapy in neonates with congenital diaphragmatic hernia-associated pulmonary hypertension: a case series Read More »

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