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Downregulation of KLF2 impairs pulmonary endothelial function and promotes persistent pulmonary hypertension of the newborn

Ningning Chen, Xiaohang Yin, Dong Wang, Dongmei Zhou, Lili Kang, Xiaoying LiChildren’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital), Cheeloo College of Medicine and Shandong University. China Biochemical PharmacologyBiochem Pharmacol 2025; DOI: 10.1016/j.bcp.2025.117572 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a severe and progressive disorder with limited therapeutic options. Dysfunction of pulmonary artery endothelial […]

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Very rare combination of Pierre Robin sequence with patent ductus arteriosus, severe persistent pulmonary hypertension, and sepsis in an Afghan neonate: a case report and literature review

Mansoor Aslamzai, Turyalai Hakimi, Abdul Hakim Mukhlis, Esrar Ahmad MansooriKabul University of Medical Sciences “Abu Ali Ibni Sina”.Afghanistan Oxford Medical Case ReportsOxf Med Case Reports 2025; DOI: 10.1093/omcr/omaf235 AbstractPierre Robin sequence (PRS) is a rare congenital abnormality that may complicate serious circumstances in infants. We report a very rare case of PRS in a five-day-old Afghan

Very rare combination of Pierre Robin sequence with patent ductus arteriosus, severe persistent pulmonary hypertension, and sepsis in an Afghan neonate: a case report and literature review Read More »

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway

Zongbin Li, Miao Zhao, Shanshan Ma, Shuyu LeiThird People’s Hospital of Xinjiang Uygur Autonomous Region. China European Journal of Medical ResearchEur J Med Res 2025; DOI: 10.1186/s40001-025-03586-0 AbstractBackground: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) drives lethal pulmonary vascular remodeling. While circular RNAs (circRNAs) are emerging as disease regulators, their functional roles in PAH-CHD remain

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway Read More »

Treatable Traits in Pediatric Interstitial Lung Diseases: Bridging the Gap to Tailored Therapeutics

Giuseppe Fabio Parisi, Maria Papale, Giulia Pecora, Santiago Presti, Monica Tosto, Salvatore LeonardiSan Marco Hospital and University of Catania.Italy Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14228190 AbstractPediatric interstitial lung diseases (chILD) are a diverse and complex group of rare but impactful disorders characterized by heterogeneous etiologies and variable clinical courses. Traditional diagnosis-based management

Treatable Traits in Pediatric Interstitial Lung Diseases: Bridging the Gap to Tailored Therapeutics Read More »

The Incidence of Pulmonary Hypertension and the Association with Bronchopulmonary Dysplasia in Preterm Infants of Extremely Low Gestational Age: Single Centre Study at the Maternity Hospital of University Medical Centre Ljubljana, Slovenia

Tomaž Križnar, Štefan Grosek, Tina PermeUniversity Medical Centre Ljubljana and University of Ljubljana.Slovenia ChildrenChildren 2025; 12: DOI: 10.3390/children12111441 AbstractBackground: Pulmonary hypertension (PH) occurs in ~25% of infants with moderate-to-severe bronchopulmonary dysplasia (BPD) and is associated with substantial morbidity and mortality. The American Heart Association and American Thoracic Society recommend routine echocardiographic screening for PH in preterm

The Incidence of Pulmonary Hypertension and the Association with Bronchopulmonary Dysplasia in Preterm Infants of Extremely Low Gestational Age: Single Centre Study at the Maternity Hospital of University Medical Centre Ljubljana, Slovenia Read More »

Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function

Pilar Blanco-Lobo, Paula Gilabert-Prieto, Beatriz de Felipe, David Moreno-Fuentes, Paloma Guisado Hernández, Ana Ortiz-Ramírez, Anna Mensa-Vilaró, Juan I. Aróstegui, Natalia Palmou, Valle Velasco Gonzalez, Ángela Deyà Martinez, Jan Ramakers, José Ivorra-Cortés, Cristina Roca, Elisa Cordero, Inmaculada Guillen, Nicolás Valerdiz Menéndez, José Manuel Lucena, Mirella Gaboli, Peter Olbrich, Olaf NethIBiS/Hospital Universitario Virgen del Rocío and CSIC/Universidad

Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function Read More »

Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage

He Zhang, Sixie Zheng, Zheng Wang, Yingying Xiao, Yuqing Hu, Debao Li, Qing Cui, Chenxi Liu, Yiting Xue, Junhua Wu, Sijuan Sun, Lincai YeAffiliated Women and Children’s Hospital of Ningbo University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China Cell

Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage Read More »

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review

Eliza Wasilewska, Norbert Dera, Łukasz Minarowski, Łukasz Osinski, Anna Doboszynska, Sławomir Szajda, Alina MinarowskaMedical University of Gdańsk. Center of Postgraduate Medical Education. Warsaw Institute of Women’s Health. Medical University of Bialystok. University Teaching Hospital. Regional Specialist Hospital in Olsztyn. University of Warmia and Mazury in Olsztyn. University of Warmia and Mazury. Children’s University Hospital in

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review Read More »

A rare case of isolated unilateral pulmonary vein atresia presenting as interstitial lung disease in a young adult

Arnav Shandil, Mansi Verma, Sushma Makhaik, Sumala KapilaIndira Gandhi Medical CollegeIndia Journal of Cardiovascular and Thoracic ResearchJ Cardiovasc Thorac Res 2025; 17: 212-214DOI: 10.34172/jcvtr.025.33139 AbstractUnilateral pulmonary vein atresia is an unusual congenital cardiovascular abnormality. It occurs due to failure of incorporation of pulmonary veins into the left atrium. It is usually diagnosed in childhood and diagnosis

A rare case of isolated unilateral pulmonary vein atresia presenting as interstitial lung disease in a young adult Read More »

Bronchopulmonary Dysplasia Definitions As Predictors of Early Childhood Pulmonary Function

Brianna C. Aoyama, Sharon A. McGrath-Morrow, Joseph M. CollacoJohns Hopkins University. University of Pennsylvania Perelman School of Medicine.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71402 AbstractObjective: To assess the clinical utility and predictive ability of three commonly used definitions of bronchopulmonary dysplasia (BPD) (2001 NHLBI, 2018 NICHD, 2019 NRN) in forecasting lung function outcomes in children

Bronchopulmonary Dysplasia Definitions As Predictors of Early Childhood Pulmonary Function Read More »

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