Class 3. Pulmonary Hypertension Associated with Lung Hypoplasia

Sex-Specific Differences in Congenital Diaphragmatic Hernia Mortality

Shelby R. Sferra, Matthew Guo, Andres J. Gonzalez-Salazar, Annalise B. Penikis, Abigail J. Engwall-Gill, Ashley Ebanks, Matthew T. Harting, Joseph M. Collaco, Shaun M. Kunisaki, CDH Study GroupJohns Hopkins University School of Medicine. University of Texas McGovern Medical School and Children’s Memorial Hermann Hospital. United States Journal of PediatricsJ Pediatr 2023; 259DOI: 10.1016/j.jpeds.2023.113481 AbstractObjective: To compare disease […]

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Quantitative Measures of Right Ventricular Size and Function by Echocardiogram Correlate with Cardiac Catheterization Hemodynamics in Congenital Diaphragmatic Hernia

Catherine M. Avitabile, Sabrina Flohr, Leny Mathew, Yan Wang, Devon Ash, David B. Frank, Jennifer E. Tingo, Natalie E. Rintoul, Holly L. HedrickUniversity of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia. United States Journal of PediatricsJ Pediatr 2023; 261DOI: 10.1016/j.jpeds.2023.113564 AbstractObjective: To evaluate associations between cardiac catheterization (cath) hemodynamics, quantitative measures of right ventricular

Quantitative Measures of Right Ventricular Size and Function by Echocardiogram Correlate with Cardiac Catheterization Hemodynamics in Congenital Diaphragmatic Hernia Read More »

Single-cell transcriptomic profiling of microvascular endothelial cell heterogeneity in congenital diaphragmatic hernia

Jason O. Robertson, Peter Bazeley, Serpil C. Erzurum, Kewal AsosinghCleveland Clinic.United States Scientific ReportsSci Rep 2023; 13DOI: 10.1038/s41598-023-37050-y AbstractCongenital diaphragmatic hernia (CDH) is a neonatal anomaly that includes pulmonary hypoplasia and hypertension. We hypothesized that microvascular endothelial cell (EC) heterogeneity is different in CDH lungs and related to lung underdevelopment and remodeling. To test this, we

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Dynamics of pulmonary hypertension severity in the first 48 h in neonates with prenatally diagnosed congenital diaphragmatic hernia

Judith Leyens, Lukas Schroeder, Annegret Geipel, Christoph Berg, Bartolomeo Bo, Lotte Lemloh, Neil Patel, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn.  Royal Hospital for Children.Germany and United Kingdom Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1164473 AbstractIntroduction: Pulmonary hypertension (PH) is one of the major contributing factors to the high morbidity and mortality in neonates with congenital

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Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia

Krithika Lingappan, Oluyinka O. Olutoye II, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J. D. Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P. Gleghorn, Sundeep G. KeswaniChildren’s Hospital of Philadelphia. Baylor College of Medicine and Texas Children’s Hospital. University of Delaware. United States American Journal of Physiology Lung Cellular and

Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia Read More »

Transcatheter Ductus Arteriosus Stenting for Acute Pediatric Pulmonary Arterial Hypertension is Associated with Improved Right Ventricular Echocardiography Strain

Jason S. Kerstein, Eleonore Valencia, Shane Collins, Alessandra M. Ferraro, David M. Harrild, Kimberlee Gauvreau, Ryan Callahan, Mary P. MullenBoston Children’s Hospital and Harvard Medical School. Children’s Hospital of Philadelphia.United States Pediatric CardiologyPediatr Cardiol 2023; DOI: 10.1007/s00246-023-03233-7 AbstractBackground: Interventional therapies for severe pulmonary arterial hypertension (PAH) can provide right ventricular (RV) decompression and preserve cardiac output. Transcatheter

Transcatheter Ductus Arteriosus Stenting for Acute Pediatric Pulmonary Arterial Hypertension is Associated with Improved Right Ventricular Echocardiography Strain Read More »

Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats

Shiho Yoshida, Alexander M. Kreger, George K. Gittes UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh School of Medicine.United States Frontiers in Bioengineering and BiotechnologyFront Bioeng Biotechnol 2023; DOI: 10.3389/fbioe.2023.1195623 AbstractPulmonary hypertension associated with congenital diaphragmatic hernia (CDH) is a critical factor in determining prognosis. We propose that intra-amniotic sildenafil administration is an effective prenatal therapy for

Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats Read More »

Failure to Normalize Biventricular Function is Associated with Extracorporeal Membrane Oxygenation Use in Neonates with Congenital Diaphragmatic Hernia

Lisa S. Le, John P. Kinsella, Jason Gien, Benjamin FrankChildren’s Hospital Colorado and University of Colorado. United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113490 AbstractWe examined post-natal echocardiograms for 62 congenital diaphragmatic hernia (CDH) infants born from 2014 through 2020. Left and right ventricular dysfunction on D0 were sensitive while persistent dysfunction on D2 was specific

Failure to Normalize Biventricular Function is Associated with Extracorporeal Membrane Oxygenation Use in Neonates with Congenital Diaphragmatic Hernia Read More »

Long-Term Functional Outcomes at 1-Year After Hospital Discharge in Critically Ill Neonates With Congenital Diaphragmatic Hernia

Jill E. O’Hara, Terry L. Buchmiller, Lori J. Bechard, Alireza Akhondi-Asl, Gary Visner, Catherine Sheils, Ronald Becker, Mollie Studley, Lindsay Lemire, Mary P. Mullen, Sally Vitali, Nilesh M. Mehta, Belinda Dickie, Jill M. Zalieckas, Ben D. AlbertBoston Children’s Hospital and Harvard Medical School. United States Pediatric Critical Care MedicinePediatr Crit Care Med 2023; DOI: 10.1097/PCC.0000000000003249 AbstractObjectives: Congenital

Long-Term Functional Outcomes at 1-Year After Hospital Discharge in Critically Ill Neonates With Congenital Diaphragmatic Hernia Read More »

Assessment of Antenatal and Postnatal Prognostic Indicators in the Outcome of Neonatal Congenital Diaphragmatic Hernia: A Prospective Observational Study

Aniruthan Deivasigamani, Bikash Kumar Naredi, Bibekanand Jindal, Kumaravel Sambandan, Krishnakumar Govindarajan, Nishad Plakkal, Mamatha GowdaJawaharlal Institute of Postgraduate Medical Education and Research. India Journal of the Indian Association of Pediatric SurgeryJ Indian Assoc Pediatr Surg 2023; 28: 122-127DOI: 10.4103/jiaps.jiaps_105_22 AbstractContext: Despite advances in neonatal intensive care, surgical methods, and anesthesia, congenital diaphragmatic hernia (CDH) is still associated

Assessment of Antenatal and Postnatal Prognostic Indicators in the Outcome of Neonatal Congenital Diaphragmatic Hernia: A Prospective Observational Study Read More »

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