Class 3. Pulmonary Hypertension Associated with Lung Disease

Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression

Shawyon P. Shirazi, Nicholas M. Negretti, Christopher S. Jetter, Alexandria L. Sharkey, Shriya Garg, Meghan E. Kapp, Devan Wilkins, Gabrielle Fortier, Saahithi Mallapragada, Nicholas E. Banovich, Laurie C. Eldredge, Gail H. Deutsch, Christopher V. E. Wright, David B. Frank, Jonathan A. Kropski, Jennifer M. S. SucreVanderbilt University Medical Center and Vanderbilt University. Translational Genomics Research […]

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Sex differences in the risk of bronchopulmonary dysplasia and pulmonary hypertension: a Bayesian meta-analysis

Elke Van Westering-Kroon, Tamara M. Hundscheid, Karen Van Mechelen, Frantisek Bartos, Steven H. Abman, Eduardo VillamorMosaKids Children’s Hospital, Maastricht University Medical Centre and Maastricht University. University of Amsterdam. University of Colorado Anschutz School of Medicine and Children’s Hospital Colorado. Netherlands and United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04145-3 AbstractBackground: Bronchopulmonary dysplasia (BPD) is generally considered to

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Pulmonary arteriole narrowing in end-stage cystic fibrosis lungs occurs with and without small airway disease

Astrid Vermaut, Gitte Aerts, Lynn Willems, Vincent Geudens, Charlotte Hooft, Pieterjan Kerckhof, Lise Vanvuchelen, Marta Zapata-Ortega, Hanne Beeckmans, Xin Jin, Yousry Mohamady, Jan Van Slambrouck, Lucia Aversa, Janne Verhaegen, Emanuela E. Cortesi, Charlotte De Fays, Birgit Weynand,Dirk E. Van Raemdonck, Laurens J. Ceulemans, Wim A. Wuyts, Marianne Carlon, Robin Vos, Natalie Lorent, Ghislaine Gayan-Ramirez, Laurent

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Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice

Yi Jin, Bernadette Chen, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00202.2024 AbstractBronchopulmonary dysplasia (BPD) is a common chronic lung disease in pediatrics. Neonatal mice placed in hyperoxia (85% oxygen, HYP) develop lung injury

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Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: Screening and Management

Samuel F. Schaeffer, Bwaar Omer, Akshaya Vachhaarajani, Chaitanya PanchangamUniversity of Missouri.United States NeoreviewsNeoreviews 2025; 26: e316-e327DOI: 10.1542/neo.26-5-013 AbstractScreening for pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD) was recommended by the American Thoracic Society in 2015. However, the definition of BPD has since changed. This review summarizes the current definition of BPD, the recommendations and

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GATA2 Deficiency With Early-Onset and Progressive Interstitial Lung Disease

Yuriko Sugiura, Takahiro Ando, Hirokazu Urushiyama, Akihisa Mitani, Goh Tanaka, Kenichi Kashimada, Tomohiro Morio, Hidenori KageUniversity of Tokyo. Institute of Science Tokyo.Japan Respirology Case ReportsRespirol Case Rep 2025; 13: DOI: 10.1002/rcr2.70165 AbstractGATA2 deficiency is a rare disease caused by germline heterozygous variants. This mutation is known to cause a decrease in haematopoietic stem cells and a

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Reduced Right Ventricular Size and Function in Adolescents and Adults Born Preterm

Zachary W. Blair, Alvin Chandra, Gregory P. Barton, Nataly Sanchez Solano, Jarett D. Berry, Kara N. GossUniversity of Texas Southwestern Medical Center. Parkland Health. University of Texas Health Tyler. United States Journal of the American Society of EchocardiographyJ Am Soc Echocardiogr 2025; DOI: 10.1016/j.echo.2025.04.007 AbstractBackground: Adults born premature have smaller cardiac chamber sizes, and some develop right

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Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients

Gabriel F. Diaz, Carlos E. Diaz‐Castrillon, Alicia Marquez Garcia, Rachel K. Hopper, Vinicio de J. PerezUniversidad Nacional De Colombia. University of Pittsburgh. Centro Policlínico Del Olaya and Clínica De La Mujer. Stanford University School of Medicine. Columbia and United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70017 AbstractPulmonary hypertension (PH) at high altitudes presents unique characteristics

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Characteristics and outcomes of preterm infants with early pulmonary hypertension

Rachel Mullaly, Aisling Smith, Claire Murphy, Seán Armstrong, Orla Franklin, Naomi McCallion, Afif EL-KhuffashRotunda Hospital. Royal College of Surgeons in Ireland. Children’s Health Ireland at Crumlin.Ireland Journal of PerinatologyJ Perinatol 2025; DOI: 10.1038/s41372-025-02295-0 AbstractObjective: This study investigates incidence, outcomes and echocardiographic characteristics of preterm infants with early pulmonary hypertension (PH) compared to those without.Study design: A prospective observational

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Neurodevelopmental outcomes at age 5 years among children born very preterm and surviving after persistent pulmonary hypertension of the newborn: EPIPAGE-2 cohort study

Sophie Breinig, Virginie Ehlinger, Jean-Christophe Rozé, Laurent Storme, Xavier Durrmeyer, Gilles Cambonie, Lionel Berthomieu, Valérie Benhammou, Geraldine Gascoin, Pierre-Yves Ancel, Catherine ArnaudChildren’s Hospital, Toulouse University Hospital and Toulouse University. Nantes University Hospital. Lille University Hospital. CHI Créteil. Montpellier University Hospital. France European Journal of Paediatric NeurologyEur J Paediatr Neurol 2025; 55: 103-110DOI: 10.1016/j.ejpn.2025.03.007 AbstractObjective: To determine whether

Neurodevelopmental outcomes at age 5 years among children born very preterm and surviving after persistent pulmonary hypertension of the newborn: EPIPAGE-2 cohort study Read More »

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