Class 3. Pulmonary Hypertension Associated with Lung Disease

Trends, Burden, and Inequality in Neonatal Pulmonary Arterial Hypertension: Global Estimates From 1990 to 2021

Xinbao Wang, Zhe Tang, Ziwei WangBeijing Friendship Hospital and Capital Medical University.China Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71277 AbstractBackground: Pulmonary arterial hypertension (PAH) is a rare but life-threatening disorder in neonates, characterized by increased pulmonary vascular resistance and right heart failure. Despite advances in neonatal intensive care, the global burden of neonatal PAH remains poorly defined, […]

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Pulmonary Hypertension Outcomes After Closure of Atrial Septal Defect in Infants With Developmental Lung Disease

John L. Wiegand, James A. Thompson, Bruce F. Landeck, Jamie L. Fierstein, Dina Ashour, Joana S. Machry, Amy L. Kiskaddon, Marisol Betensky, Grace A. FreireUniversity of South Florida Morsani College of Medicine. Johns Hopkins All Children’s Hospital. United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70164 AbstractPulmonary hypertension (PHTN) in infants with developmental lung disease, such

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Respiratory Outcomes Following Late Postnatal Dexamethasone Administration in Preterm Infants With Bronchopulmonary Dysplasia

Melissa House, James Rowe, Audrey Walters, Chunyan Liu, Shelley R. Ehrlich, Thomas Nienaber, Erik B. Hysinger, Paul Kingma, Shawn K. AhlfeldEmory University School of Medicine and Children’s Healthcare of Atlanta. Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71275 AbstractObjective: To wean respiratory support, preterm infants

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Screening for pulmonary hypertension in preterm infants with bronchopulmonary dysplasia: when, how often and does it matter?

Samuel J. Gentle, Waldemar A. Carlo, Namasivayam AmbalavananUniversity of Alabama at Birmingham. Yale School of Medicine.United States Archives of Disease in Childhood Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2025; DOI: 10.1136/archdischild-2024-328405 AbstractObjective: Bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (BPD-PH) is the most severe endotype of BPD; there is insufficient evidence to support the optimal

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p53 maintains lineage fidelity during lung capillary injury-repair in neonatal hyperoxia

Lisandra Vila Ellis, Jonathan D. Bywaters, Amanda Ceas, Yun Liu, Jennifer M. S. Sucre, Jichao ChenNorthwestern University.  Vanderbilt University Medical Center. Cincinnati Children’s Hospital Medical Center.United States Journal of Clinical Investigation InsightsJCI Insights 2025;DOI: 10.1172/jci.insight.182880 AbstractBronchopulmonary dysplasia (BPD), a prevalent and chronic lung disease affecting premature newborns, results in vascular rarefaction and alveolar simplification. Although the

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Clinical Characteristics and Outcomes for Neonates with Respiratory Failure Referred for Extracorporeal Membrane Oxygenator (ECMO) Support

Pooja Musuku, Keith Meyer, Felipe E. Pedroso, Fuad Alkhoury, Balagangadhar R. TotapallyNicklaus Children’s Hospital. Herbert Wertheim College of Medicine and Florida International University.United States ChildrenChildren 2025; 12: DOI: 10.3390/children12070925 AbstractObjective: The aim of this study was to describe the presenting characteristics and outcomes of neonates with respiratory failure referred for extracorporeal membrane oxygenation (ECMO) support, compare

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Impact of Pulmonary Hypertension and Patent Ductus Arteriosus in Preterm Infants with Presumed Pulmonary Hypoplasia

Sol Kim, Yumi Seo, Moon-Yeon Oh, Min Soo Kim, Sook Kyung YumSeoul St. Mary’s Hospital and Catholic University of Korea.Republic of Korea BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13071725 AbstractObjectives: Pulmonary hypertension and hemodynamically significant PDA (hsPDA) involve seemingly opposite physiological features-decreased pulmonary blood flow and pulmonary overcirculation, respectively-but the literature demonstrates variable respiratory consequences in association with

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Outcomes of extremely preterm infants with bronchopulmonary dysplasia: a retrospective cohort study

Ashraf Gad, Rowan Mesilhy, Thomas Maveli, FatimaAli, Noora Jasim, MalazAdam, Tasneim Abdalla, Mohamed Madani, Mohammad Ayman Alkhateeb, Mohammad A. A. BayoumiHamad Medical Corporation. Qatar University. Sidra Medicine. Qatar Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-12066-8 AbstractTo investigate the respiratory and related health outcomes at 18 months for extremely preterm (EP) infants diagnosed with bronchopulmonary dysplasia (BPD).

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The effectiveness of pulmonary hypertension screening in infants born preterm

Stephanie Vachon, Rajiv Devanagondi, Andrew Dylag, Hongyue Wang, Gloria PryhuberUniversity of Rochester Medical Center. University of Iowa Stead Family Department of Pediatrics. United States Early Human DevelopmentEarly Hum Dev 2025; DOI: 10.1016/j.earlhumdev.2025.106342 AbstractObjective: To determine if pulmonary hypertension (PH) screening in at-risk infants born preterm reduces morbidity and/or NICU length of stay.Study design: This single-center retrospective cohort chart

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Variability in Home Oxygen Therapy Practices for Bronchopulmonary Dysplasia in Japan: A Questionnaire Survey

Ryo Ogawa, Masaki Hasebe, Tomohiko Nakamura, Fumihiko NambaNagano Children’s Hospital. Saitama Medical Center and Saitama Medical University.Japan Journal of Paediatrics and Child HealthJ Paediatr Child Health 2025; DOI: 10.1111/jpc.70150 AbstractAim: To examine variations in home oxygen therapy (HOT) initiation and management practices for bronchopulmonary dysplasia (BPD) among perinatal medical centres in Japan.Methods: A questionnaire survey was distributed to

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