Class 3. Pulmonary Hypertension Associated with Lung Disease

Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension

Shyam Thapa, Poonam Sarkar, M. Waleed Gaber, Roberto Barrios, Madhulata Chauhan, Chandrasekhar Yallampalli, Binoy ShivannaTexas Children’s Hospital and Baylor College of Medicine. Houston Methodist HospitalUnited States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00234.2025 AbstractBronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH) or BPD-PH is a lung […]

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Optimal Therapeutic Strategy for Ventricular Septal Defect Closure in Extremely Preterm Infants with Chronic Lung Disease and Severe Pulmonary Hypertension

Akari Sato, Mai Sekine, Hidenori Kawasaki, Masayo Kanai, Hirotaka Ishido, Yoichi Iwamoto, Hideaki Senzaki, Ayumu Masuoka, Fujito Numano, Jun Muneuchi, Norie Mitsushita, Satoshi MasutaniSaitama Medical Center and Saitama Medical University. Nihon Institute of Medical Science. International Medical Center. Niigata University Graduate School of Medical and Dental Sciences. Kyushu Hospital and Japan Community Healthcare Organization. Shizuoka

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Chronic Lung Disease-Related Pulmonary Hypertension in Children

Jason E. Lang, Kevin D. HillDuke Clinical Research Institute and Duke University School of Medicine. United States Acta PaediatricaActa Paediatr 2025; DOI: 10.1111/apa.70320 AbstractAim: Pulmonary hypertension (PH) is characterised by elevated pressures in the pulmonary arterial system. Despite its high mortality, paediatric PH has few approved treatments. Our aim was to review the latest diagnostic and treatment

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Clinico-epidemiological Characteristics of Children with Cystic Fibrosis: a Tertiary Care Experience

Probir K. Sarker, N. Akand, S. Tahura. M. Kamruzzaman, J. Akter, K. A. Zaman, T. Farhana, M. M. Hossain, M. J. Alam, M. A. S. Khan, M. J. HasanBangladesh Shishu Hospital & Institute. Bangladesh Mymensingh Medical Journal Mymensingh Med J 2025; 34: 1070-1080DOI Not Available AbstractTo describe the clinico-epidemiological characteristics of pediatric cystic fibrosis (CF)

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Bronchopulmonary dysplasia, pulmonary hypertension, and neonatal gastroesophageal reflux: Association, causation, or neither?

Erik A. JensenStanford University School of Medicine and Lucile Packard Children’s Hospital.United States Seminars in PerinatologySemin Perinatol 2025; DOI: 10.1016/j.semperi.2025.152158 AbstractBronchopulmonary dysplasia (BPD) is among the most common and serious complications of prematurity. The pathobiology of BPD and BPD associated pulmonary arterial hypertension (BPD-PH) is multifactorial and not yet fully defined. Gastroesophageal reflux (GER), a physiologic

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Trends, Burden, and Inequality in Neonatal Pulmonary Arterial Hypertension: Global Estimates From 1990 to 2021

Xinbao Wang, Zhe Tang, Ziwei WangBeijing Friendship Hospital and Capital Medical University.China Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71277 AbstractBackground: Pulmonary arterial hypertension (PAH) is a rare but life-threatening disorder in neonates, characterized by increased pulmonary vascular resistance and right heart failure. Despite advances in neonatal intensive care, the global burden of neonatal PAH remains poorly defined,

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Pulmonary Hypertension Outcomes After Closure of Atrial Septal Defect in Infants With Developmental Lung Disease

John L. Wiegand, James A. Thompson, Bruce F. Landeck, Jamie L. Fierstein, Dina Ashour, Joana S. Machry, Amy L. Kiskaddon, Marisol Betensky, Grace A. FreireUniversity of South Florida Morsani College of Medicine. Johns Hopkins All Children’s Hospital. United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70164 AbstractPulmonary hypertension (PHTN) in infants with developmental lung disease, such

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Respiratory Outcomes Following Late Postnatal Dexamethasone Administration in Preterm Infants With Bronchopulmonary Dysplasia

Melissa House, James Rowe, Audrey Walters, Chunyan Liu, Shelley R. Ehrlich, Thomas Nienaber, Erik B. Hysinger, Paul Kingma, Shawn K. AhlfeldEmory University School of Medicine and Children’s Healthcare of Atlanta. Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71275 AbstractObjective: To wean respiratory support, preterm infants

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Screening for pulmonary hypertension in preterm infants with bronchopulmonary dysplasia: when, how often and does it matter?

Samuel J. Gentle, Waldemar A. Carlo, Namasivayam AmbalavananUniversity of Alabama at Birmingham. Yale School of Medicine.United States Archives of Disease in Childhood Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2025; DOI: 10.1136/archdischild-2024-328405 AbstractObjective: Bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (BPD-PH) is the most severe endotype of BPD; there is insufficient evidence to support the optimal

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p53 maintains lineage fidelity during lung capillary injury-repair in neonatal hyperoxia

Lisandra Vila Ellis, Jonathan D. Bywaters, Amanda Ceas, Yun Liu, Jennifer M. S. Sucre, Jichao ChenNorthwestern University.  Vanderbilt University Medical Center. Cincinnati Children’s Hospital Medical Center.United States Journal of Clinical Investigation InsightsJCI Insights 2025;DOI: 10.1172/jci.insight.182880 AbstractBronchopulmonary dysplasia (BPD), a prevalent and chronic lung disease affecting premature newborns, results in vascular rarefaction and alveolar simplification. Although the

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