Class 1. Persistent Pulmonary Hypertension of the Newborn

Persistent Pulmonary Hypertension of the Newborn: Should Sildenafil and Inhaled Nitric Oxide at Medium Concentration Be the Standard of Treatment?

Ivan D. Florez, Luisa Parra-RodasUniversidad de Antioquia. McMaster University. Clínica Las Américas-AUNA. Universidad Pontificia Bolivariana.Columbia and Canada Critical Care MedicineCrit Care Med 2024; 52: 995-997DOI: 10.1097/CCM.0000000000006278 AbstractAbstract Not Available (Editorial) CategoryClass I. Persistent Pulmonary Hypertension of the NewbornMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). […]

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Milrinone in persistent pulmonary hypertension of newborn: a scoping review

Radu Galis, Diane Mudura, Paula Trif, Shivashankar Diggikar, Arun Prasath, Maria Livia Ognean, Jan Mazela, Adrian Lacatusu, Rangasamy Ramanathan, Boris W. Kramer, Yogen SinghEmergency County Hospital Bihor. Poznan University of Medical Sciences. University of Oradea. Oyster Woman and Child Hospital. University of Texas Southwestern. Lucian Blaga University Sibiu. Clinical County Emergency Hospital Sibiu. Emergency County

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A Nomogram Prediction Model for Persistent Pulmonary Hypertension of the Newborn in Neonates Hospitalized for the First Time After Birth

Yan Zhang, Juan Wen, Min Zeng, Limei Zhang, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University. Women’s Hospital of Nanjing Medical University and Nanjing Women and Children’s Healthcare Hospital.China Pediatric Emergency CarePediatr Emerg Care 2024; DOI: 10.1097/PEC.0000000000003167 AbstractObjective: Persistent pulmonary hypertension of the newborn (PPHN) is one of the critical neonatal diseases associated with high morbidity and

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Effect of prone positioning ventilation on pulmonary function in neonates during venous-arterial extracorporeal membrane oxygenation

Kai-Peng Sun, Si-Jia Zhou, Xiu-Hua Chen, Yi-Rong Zheng, Qiang ChenFujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center) and Fujian Medical University.China Translational PediatricsTransl Pediatr 2024; 13: 575-583DOI: 10.21037/tp-23-485 AbstractBackground: The use of extracorporeal membrane oxygenation (ECMO) technology has significantly decreased mortality rates associated with neonatal pulmonary hypertension and respiratory failure. Prone positioning ventilation (PPV) is

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Persistent Pulmonary Hypertension of Newborns Secondary to Labile Hypoxemia Associated With Cyanosis: A Case Series

Anushka P. Bhagwat, H. V. Sharath, Nikita H. Seth, Saurabh N. PuriDatta Meghe Institute of Higher Education and Research.India CureusCureus 2024; 16:DOI: 10.7759/cureus.54016 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a condition that can be fatal, marked by increased pulmonary vascular resistance that causes blood to shunt from the right to the left. Six infants

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Occurrence of hyperoxia during iNO treatment for persistent pulmonary hypertension of the newborn: a cohort study

Justine de Jager, Fleur Brouwer, Jeroen Reijman, Roel L. F. van der Palen, Sylke J. Steggerda, Remco Visser, Arjan B. te Pas, Janneke DekkerLeiden University Medical Center.Netherlands European Journal of PediatricsEur J Pediatr 2024;DOI: 10.1007/s00431-024-05506-6 AbstractHigh concentrations of oxygen are often needed to optimize oxygenation in infants with persistent pulmonary hypertension (PPHN), but this can also

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Neonatal persistent pulmonary hypertension related to a novel TBX4 mutation: case report and review of the literature

Chiara Maddaloni, Sara Ronci, Domenico Umberto De Rose, Iliana Bersani, Francesca Campi, Matteo Di Nardo, Francesca Stoppa, Rachele Adorisio, Antonio Amodeo, Alessandra Toscano, Maria Cristina Digilio, Antonio Novelli, Giovanni Chello, Annabella Braguglia, Andrea Dotta, Flaminia Calzolar“Bambino Gesù” Children’s Hospital IRCCS. Monaldi Hospital.Italy Italian Journal of PediatricsItal J Pediatr 2024; 50:DOI: 10.1186/s13052-024-01575-3 AbstractTBX4 gene, located on human

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Serum pentraxin 3 levels in term neonates with persistent pulmonary hypertension

A. E. A. Asal, Z. F. Oshaiba, E. N. A. Mansour, O. H. Abd Elazir, A. A. A. NasrAl-Azhar University (for girls).Egypt Journal of Neonatal and Perinatal MedicineJ Neonatal Perinatal Med 2024;DOI: 10.3233/NPM-230211 AbstractBackground: Persistent pulmonary hypertension of the neonate (PPHN) is a serious disorder. The long pentraxin 3 (PTX3) plays an important role in angiogenesis, cell

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Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension

Michael W. Cookson, John P. KinsellaUniversity of Colorado Anschutz School of Medicine and Children’s Hospital Colorado.United States Clinics in PerinatologyClin Perinatol 2024; 51: 95-111DOI: 10.1016/j.clp.2023.11.001 AbstractPivotal trials investigating the use of inhaled nitric oxide (iNO) in the 1990s led to approval by the Food and Drug Administration in 1999. Inhaled nitric oxide is the only approved

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Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, “Precision-Medicine” Approach

Satyan Lakshminrusimha, Steven H. AbmanUniversity of California, Davis Children’s Hospital. University of Colorado Anschutz Medical Campus.United States Clinics in PerinatologyClin Perinatol 2024; 51: 77-94DOI: 10.1016/j.clp.2023.12.003 AbstractOxygen is a specific pulmonary vasodilator. Hypoxemia causes pulmonary vasoconstriction, and normoxia leads to pulmonary vasodilation. However, hyperoxia does not enhance pulmonary vasodilation but causes oxidative stress. There are no clinical

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