Class 1. Persistent Pulmonary Hypertension of the Newborn

Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia-A Recipe for Severe Pulmonary Hypertension?

Deepika Sankaran, Jessa Rose A. Li, Satyan LakshminrusimhaUniversity of California, Davis.United States ChildrenChildren 2024; DOI: 10.3390/children11060673 AbstractHypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality among term newborns globally. Infants born through meconium-stained amniotic fluid are at risk of developing meconium aspiration syndrome (MAS) and HIE. Simultaneous occurrence of MAS and HIE is a perilous combination […]

Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia-A Recipe for Severe Pulmonary Hypertension? Read More »

Deep Learning Based Prediction of Pulmonary Hypertension in Newborns Using Echocardiograms

Hanna Ragnarsdottir, Ece Ozkan, Holger Michel, Kieran Chin-Cheong, Laura Manduchi, Sven Wellmann, Julia E. VoETH Zurich. Massachusetts Institute of Technology. University Children’s Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John and University of Regensburg.Switzerland, United States and Germany International Journal of Computer VisionInt J Comput Vis 2024; 132: 2567–2584DOI: 10.1007/s11263-024-01996-x AbstractPulmonary hypertension

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Aberrant PGC-1α signaling in a lamb model of persistent pulmonary hypertension of the newborn

Emily A. Mooers, Hollis M. Johnson, Teresa Michalkiewicz, Ujala Rana, Chintamani Joshi, Adeleye J. Afolayan, Ru-Jeng Teng, Girija G. KonduriMedical College of Wisconsin.United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03223-2 AbstractBackground: Persistent Pulmonary Hypertension of the Newborn (PPHN) is characterized by elevated pulmonary vascular resistance (PVR), resulting in hypoxemia. Impaired angiogenesis contributes to high PVR. Pulmonary artery

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Multisystem Inflammatory Syndrome in Neonates Associated with COVID-19 in Neonatal ICU of a Tertiary Care Hospital

Asma Shabbir, Humaira Khurshid, Imran Mahmood KhanFazaia Medical College, Pakistan Air Force Hospital.Pakistan Journal of the College of Physicians and Surgeons PakistanJ Coll Physicians Surg Pak 2024; 34: 727-731 DOI: 10.29271/jcpsp.2024.06.727 AbstractObjective: Neonatal multisystem inflammatory syndrome (MIS-N) is a unique disease of neonates described in several case reports from all over the world with a myriad of

Multisystem Inflammatory Syndrome in Neonates Associated with COVID-19 in Neonatal ICU of a Tertiary Care Hospital Read More »

Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn (PPHN): when to think beyond reversible causes

Stephanie M. Tsoi, Martina Steurer, Hythem Nawaytou, Shannon Cheung, Roberta L. Keller, Jeffrey R. FinemanUniversity of California San Francisco. United States Journal of PediatricsJ Pediatr 2024; DOI: 10.1016/j.jpeds.2024.114131 AbstractObjectives: To describe the typical clinical course of reversible PPHN from perinatal etiologies and compare that with the clinical course of PPHN due to underlying fetal developmental etiologies.Study design: This

Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn (PPHN): when to think beyond reversible causes Read More »

Improvement in Echocardiographic and Diagnostic Biomarkers after Systemic Glucocorticoid Therapy in Infants with Pulmonary Hypertension

Brian S. Hernandez, Rod M. Shinozaki, R. Mark Grady, Andrea Drussa, Erica Jamro-Comer, Jinli Wang, Manish AggarwalWashington University School of Medicine. Loma Linda University Children’s Hospital. United States Journal of PediatricsJ Pediatr 2024; DOI: 10.1016/j.jpeds.2024.114116 AbstractObjective: To assess the effect of treating pulmonary hypertension (PH) in infants less than 1 year of age with systemic glucocorticoids while

Improvement in Echocardiographic and Diagnostic Biomarkers after Systemic Glucocorticoid Therapy in Infants with Pulmonary Hypertension Read More »

Vasoactive Management of Pulmonary Hypertension and Ventricular Dysfunction in Neonates Following Complicated Monochorionic Twin Pregnancies: A Single-Center Experience

Lukas Schroeder, Leon Soltesz, Judith Leyens, Brigitte Strizek, Christoph Berg, Andreas Mueller, Florian KipfmuellerUniversity Children’s Hospital Bonn and University Hospital Bonn. University of Cologne.Germany ChildrenChildren 2024; 11:DOI: 10.3390/children11050548 AbstractObjectives: Twins resulting from a complicated monochorionic (MC) twin pregnancy are at risk for postnatal evolution of pulmonary hypertension (PH) and cardiac dysfunction (CD). Both pathologies are important contributors

Vasoactive Management of Pulmonary Hypertension and Ventricular Dysfunction in Neonates Following Complicated Monochorionic Twin Pregnancies: A Single-Center Experience Read More »

Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial

Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama DabbaghIran University of Medical Sciences. Shahid Akbar Abadi Hospital. Iran Pediatrics and NeonatologyPediatr Neonatol 2024; DOI: 10.1016/j.pedneo.2023.12.007 AbstractBackground: Persistent Pulmonary Hypertension of the newborn (PPHN) is characterized by sustained elevated Pulmonary Artery Pressure (PAP). Drug resistance and the adverse effects of current therapeutic agents warrant investigation of other

Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial Read More »

Transitional Hemodynamics in Neonates Born Through Meconium-Stained Amniotic Fluid: A Prospective Observational Study

Kamal Joshi, Mayank Priyadarshi, Yash Shrivastava, Suman Chaurasia, Poonam Signh, Nowneet Kumar Bhat, Sriparna BasuAll India Institute of Medical Sciences. India Pediatric CardiologyPediatr Cardiol 2024; DOI: 10.1007/s00246-024-03521-w AbstractNeonates born through meconium-stained amniotic fluid (MSAF) are at increased risk of altered cardiopulmonary transition at birth. There is a paucity of literature evaluating the transitional hemodynamics in these

Transitional Hemodynamics in Neonates Born Through Meconium-Stained Amniotic Fluid: A Prospective Observational Study Read More »

Enhancing Neonatal Care: The Vital Role of Pulse Oximetry in the Early Screening of Critical Congenital Heart Diseases and Respiratory Diseases in Rural Areas

Prajyoth M. Gaonkar, Saurabh R. Mutha, Isha M. SanghaniPunyashlok Ahilyadevi Holkar Government Medical College.India CureusCureus 2024; 16: DOI: 10.7759/cureus.58398 AbstractBackground: Pulse oximetry screening (POS) is acknowledged globally as a noninvasive method to detect critical congenital heart diseases (CCHDs) and respiratory illnesses. However, its value for early diagnosis and treatment remains unrecognized in many hospitals with limited

Enhancing Neonatal Care: The Vital Role of Pulse Oximetry in the Early Screening of Critical Congenital Heart Diseases and Respiratory Diseases in Rural Areas Read More »