Class 1. Persistent Pulmonary Hypertension of the Newborn

Pulmonary comorbidities and response to surfactant in late preterm infants: a multicenter cohort study

Iwona Sadowska-Krawczenko, Roman Hożejowski, Jan Mazela, Katarzyna Wróblewska-Seniuk, Tomasz Szczapa, Mateusz Jagła, Piotr Kruczek, Katarzyna Bierła, Renata BokiniecNicolaus Copernicus University in Torun. University Hospital No. 2 in Bydgoszcz. Chiesi Poland. Poznan University of Medical Sciences. Jagiellonian University Medical College. Czerwiakowski Hospital at Siemiradzki. District Hospital, Ostrow. Medical University of Warsaw.Poland Pediatric ResearchPediatr Res 2025;DOI: 10.1038/s41390-025-04634-5 AbstractBackground: Surfactant […]

Pulmonary comorbidities and response to surfactant in late preterm infants: a multicenter cohort study Read More »

Downregulation of KLF2 impairs pulmonary endothelial function and promotes persistent pulmonary hypertension of the newborn

Ningning Chen, Xiaohang Yin, Dong Wang, Dongmei Zhou, Lili Kang, Xiaoying LiChildren’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital), Cheeloo College of Medicine and Shandong University. China Biochemical PharmacologyBiochem Pharmacol 2025; DOI: 10.1016/j.bcp.2025.117572 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a severe and progressive disorder with limited therapeutic options. Dysfunction of pulmonary artery endothelial

Downregulation of KLF2 impairs pulmonary endothelial function and promotes persistent pulmonary hypertension of the newborn Read More »

Very rare combination of Pierre Robin sequence with patent ductus arteriosus, severe persistent pulmonary hypertension, and sepsis in an Afghan neonate: a case report and literature review

Mansoor Aslamzai, Turyalai Hakimi, Abdul Hakim Mukhlis, Esrar Ahmad MansooriKabul University of Medical Sciences “Abu Ali Ibni Sina”.Afghanistan Oxford Medical Case ReportsOxf Med Case Reports 2025; DOI: 10.1093/omcr/omaf235 AbstractPierre Robin sequence (PRS) is a rare congenital abnormality that may complicate serious circumstances in infants. We report a very rare case of PRS in a five-day-old Afghan

Very rare combination of Pierre Robin sequence with patent ductus arteriosus, severe persistent pulmonary hypertension, and sepsis in an Afghan neonate: a case report and literature review Read More »

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review

Eliza Wasilewska, Norbert Dera, Łukasz Minarowski, Łukasz Osinski, Anna Doboszynska, Sławomir Szajda, Alina MinarowskaMedical University of Gdańsk. Center of Postgraduate Medical Education. Warsaw Institute of Women’s Health. Medical University of Bialystok. University Teaching Hospital. Regional Specialist Hospital in Olsztyn. University of Warmia and Mazury in Olsztyn. University of Warmia and Mazury. Children’s University Hospital in

Can Milrinone Be a Therapeutic Alternative in Persistent Pulmonary Hypertension of the Newborn? A Case Series and Narrative Review Read More »

Fetal Ductal Constriction, Pulmonary Hypertension and Atrial Septum Mobility: A Correlation Study

Paulo Zielinsky, Polyanna Henriques, Pedro Van Der Sand, Maria Antonia Saldanha, Gabriela Macelaro, Joana NicolosoFundação Universitária de Cardiologia-IC/FUC. Universidade Federal do Rio Grande do Sul-UFRGS.Brazil Journal of Ultrasound in MedicineJ Ultrasound Med 2025; DOI: 10.1002/jum.70130 AbstractObjectives: Fetuses with ductal constriction (FDC), pulmonary hypertension and right ventricular overload after maternal exposure to PGE2 inhibitors-nonsteroidal anti-inflammatory drugs (NSAIDs) or

Fetal Ductal Constriction, Pulmonary Hypertension and Atrial Septum Mobility: A Correlation Study Read More »

Early Oxygenation and Mortality in Infants Treated with Inhaled Nitric Oxide (iNO) for Persistent Pulmonary Hypertension of the Newborn (PPHN)

Marina S. Oren, Kikelomo Babata, June Hu, Venkatakrishna Kakkilaya, Patti J. Burchfield, Michelle Hagans, L. Steven Brown, Satyan Lakshminrusimha, Vishal KapadiaUniversity of Texas Southwestern Medical Center. Texas Health Presbyterian Hospital of Dallas. Parkland Health & Hospital System. University of California Davis Children’s Hospital.United States Journal of Pediatrics: Clinical PracticeJ Pediatr Clin Pract 2025; 18: DOI: 10.1016/j.jpedcp.2025.200189

Early Oxygenation and Mortality in Infants Treated with Inhaled Nitric Oxide (iNO) for Persistent Pulmonary Hypertension of the Newborn (PPHN) Read More »

The impact and outcome of the presence of ductus arteriosus in neonatal peripheral extracorporeal membrane oxygenation

Hsi-Yun Liu, Ming-Chou Cheng, Shao-Ju Chien, Ying-Jui Lin, Hsuan-Chang Kuo, Mei-Hsin Hsu, Chien-Te Lee, Jiunn-Jye SheuKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine. Cheng Shiu University. Taiwan Pediatrics and NeonatologyPediatr Neonatol 2025; DOI: 10.1016/j.pedneo.2025.06.007 AbstractBackground: This study aimed to investigate the impact of the patent ductus arteriosus (DA) on pulmonary conditions and to

The impact and outcome of the presence of ductus arteriosus in neonatal peripheral extracorporeal membrane oxygenation Read More »

Cardiology Overview of Pulmonary Hypertension Management in the Neonatal Intensive Care Unit

Rebecca J. Kameny, Rachel K. HopperStanford University.United States Clinics in PerinatologyClin Perinatol 2025; 52: 633-653DOI: 10.1016/j.clp.2025.08.002 AbstractPulmonary hypertension (PH) in the neonatal intensive care unit represents a complex and diverse spectrum of conditions, from transient persistent pulmonary hypertension of the newborn to chronic PH associated with bronchopulmonary dysplasia, congenital heart disease, and other conditions, and can

Cardiology Overview of Pulmonary Hypertension Management in the Neonatal Intensive Care Unit Read More »

Persistent Pulmonary Hypertension of the Newborn: A Pragmatic Review of Pathophysiology, Diagnosis, and Advances in Management

Karolina Chojnacka, Yogen Singh, Sheen Gahlaut, Witold Blaz, Agata Jerzak, Tomasz SzczapaPoznan University of Medical Sciences. University of California and UC Davis Children’s Hospital. Oxford University. Saint Jadwiga the Queen Clinical Provincial Hospital and University of Rzeszow.Poland, United States and United Kingdom BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13102332 AbstractPersistent pulmonary hypertension of the newborn (PPHN) results from

Persistent Pulmonary Hypertension of the Newborn: A Pragmatic Review of Pathophysiology, Diagnosis, and Advances in Management Read More »

Abnormal Fetal/Neonatal Lung Development Manifested as Some Functional Heart Abnormalities During the Third Trimester of Fetal Life

Julia Murlewska, Oskar Sylwestrzak, Maciej Słodki, Iwona Strzelecka, Łukasz Sokołowski, Monika Wójtowicz-Marzec, Iwona Maroszynska, Ewa Cichos, Hanna Romanowicz, Anita J. Moon-Grady, Maria Respondek-LiberskaPolish Mother’s Memorial Hospital Research Institute. Mazovian Academy in Plock. Medical University of Lodz. Medical University of Lublin. Benioff Children’s Hospital and University of California, San Francisco.Poland and United States BiomedicinesBiomedicines 2025; 13:

Abnormal Fetal/Neonatal Lung Development Manifested as Some Functional Heart Abnormalities During the Third Trimester of Fetal Life Read More »

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