Class 1. Persistent Pulmonary Hypertension of the Newborn

Etiologies of Pulmonary Arterial Hypertension in Early Infants: A 4-year Experience from a Tertiary Care Center in Southern India

Ysphaneendra Mallimoggala, Monalisa Biswas, Nitin Thyagaraja, H. Koushik, Krishnananda Nayak, Shrikiran Aroor, Varashree Bolar Suryakanth, Leslie LewisKasturba Medical College of Manipal Academy of Higher Education, Manipal College of Health Professionals and National Institute of Mental Health and Neuro Sciences. India Annals of African MedicineAnn Afr Med 2026; DOI: 10.4103/aam.aam_555_26 AbstractIntroduction: Pulmonary arterial hypertension (PAH) is relatively uncommon

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Pulmonary hypertension and acute hypoxic respiratory failure in preterm neonates

Marwa M. Elgendy, Sfurti NathUniversity of Maryland School of Medicine. Warren Alpert Medical School of Brown University.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02858-9 AbstractPulmonary hypertension (PH) in preterm infants is a complex and heterogeneous condition that significantly contributes to hypoxic respiratory failure (HRF), bronchopulmonary dysplasia (BPD), and mortality. Unlike term infants, PH in preterm

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Clinical effects of persistent pulmonary hypertension in newborns diagnosed with transposition of the great arteries

Halise Zeynep Genc, Huseyin Ceylan, Hacer Kamali, Eymen Recep, Ali Can Hatemi, Sertac Haydin, Alper Guzeltas, Erkut OzturkSaglik Bilimleri University, Basaksehir Cam and Sakura City Hospital and Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital. Turkey Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2026; 13: DOI: 10.3389/fcvm.2026.1888066 AbstractIntroduction: Transposition of the great arteries (TGA) is

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Vasopressin for hemodynamic support in neonates: current evidence and clinical applications

Aimann Surak, Mohamed Sewidan, Mimi T. Y. Kuan, Megan Kennedy, Manoj Kumar, Joseph Y. TingUniversity of Alberta. University of British Columbia. Canada Journal of PerinatologyJ Perinatol 2026;DOI: 10.1038/s41372-026-02837-0 AbstractObjective: To systematically map and synthesize the available evidence on the use of vasopressin for hemodynamic support in neonates.Study design: We conducted a scoping review to synthesize available data on

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Placental abnormalities of malperfusion, inflammation, and meconium are associated with neonatal pulmonary vascular disease

Stephanie M. Tsoi, Cynthia Gasper, Emin Maltepe, Megan A. Chidboy, Nida Ozarslan, Christine A. Blauvelt, Sirirak Buarpung, Shannon Cheung, Martina Steurer, Roberta L. Keller, Jeffrey R. Fineman, Stephanie L. GawUniversity of California San Francisco. United States PlacentaPlacenta 2026; 182: 341-347DOI: 10.1016/j.placenta.2026.06.024 AbstractObjectives: The primary objective was to elucidate whether placental histopathology representative of intrauterine insults during pulmonary

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Physiological-Based Cord Clamping and Early Oxygenation in Newborns With Transposition of the Great Arteries: A Quality Improvement Study Protocol

Jesse A. Weeda, Arjan B. te Pas, Zsuzsanna Nagy, Gábor H. Kovács, Miklós Szabó, Gergo} Leipold, Nariae Baik-Schneditz, Bernhard Schwaberger, Christian Heiring, Emma Louise Malchau Carlsen, Monique C. Haak, Nico A. Blom, Stuart B. Hooper, Janneke Dekker, Roel L.F. van der PalenWillem-Alexander Children’s Hospital and Leiden University Medical Center. Semmelweis University. Gottsegen National Cardiovascular Centre.

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Early Detection of Isolated Transient Right Ventricular Hypertrophy in a Term Neonate: the Neonatologist’s Role

Evgeniya Babacheva, Evangelia Giannousiou, Maria Florou, Apostolia Stampouli, Maria Lithoxopoulou, Christos TsakalidisAristotle University of Thessaloniki and “Papageorgiou” Hospital.Greece MaedicaMaedica 2026; 21: 539-542DOI: 10.26574/maedica.2026.21.2.539 AbstractRight ventricular hypertrophy (RVH) is a rare finding in the neonatal age. Multiple pathological conditions are associated with the development of RVH, such as metabolic diseases, hereditary disorders and premature closure of the

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L-Citrulline in Maternal-Fetal and Neonatal Health: Metabolic Mechanisms and Emerging Therapeutic Applications

Ana Collins-Smith, Sangeeta Jain, Sunil JainUniversity of Texas Medical Branch at Galveston.United States NutrientsNutrients 2026; 18: DOI: 10.3390/nu18121923 AbstractL-citrulline is a non-protein amino acid with critical roles in perinatal and neonatal physiology through the intestinal-renal arginine-citrulline axis and nitric oxide (NO) production. During pregnancy, L-citrulline supports placental angiogenesis, vascular adaptation, and fetal growth through augmentation of

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Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition

Tomaž Podnar, Ralf Geiger, Ira Winkler, Elke Griesmaier, Susanne Sprung, Ursula Kiechl-KohlendorferMedical University of Innsbruck. Tirol Kliniken.Austria Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1753196 AbstractBackground: The foramen ovale (FO) plays a central role in fetal circulation. Prenatal FO closure or restriction is well-characterized in fetuses and in neonates with congenital heart defects, but is rarely described

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Efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis

Guanghong Li, Xiaoqun Du, Weibin Luo, Junhua Wei, Huiyi HuangHuadu District People’s Hospital of Guangzhou.China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1836276 AbstractObjective: To evaluate the efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN).Methods: PubMed, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched from inception to March

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