Class 1. Persistent Pulmonary Hypertension of the Newborn

Early Detection of Isolated Transient Right Ventricular Hypertrophy in a Term Neonate: the Neonatologist’s Role

Evgeniya Babacheva, Evangelia Giannousiou, Maria Florou, Apostolia Stampouli, Maria Lithoxopoulou, Christos TsakalidisAristotle University of Thessaloniki and “Papageorgiou” Hospital.Greece MaedicaMaedica 2026; 21: 539-542DOI: 10.26574/maedica.2026.21.2.539 AbstractRight ventricular hypertrophy (RVH) is a rare finding in the neonatal age. Multiple pathological conditions are associated with the development of RVH, such as metabolic diseases, hereditary disorders and premature closure of the […]

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L-Citrulline in Maternal-Fetal and Neonatal Health: Metabolic Mechanisms and Emerging Therapeutic Applications

Ana Collins-Smith, Sangeeta Jain, Sunil JainUniversity of Texas Medical Branch at Galveston.United States NutrientsNutrients 2026; 18: DOI: 10.3390/nu18121923 AbstractL-citrulline is a non-protein amino acid with critical roles in perinatal and neonatal physiology through the intestinal-renal arginine-citrulline axis and nitric oxide (NO) production. During pregnancy, L-citrulline supports placental angiogenesis, vascular adaptation, and fetal growth through augmentation of

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Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition

Tomaž Podnar, Ralf Geiger, Ira Winkler, Elke Griesmaier, Susanne Sprung, Ursula Kiechl-KohlendorferMedical University of Innsbruck. Tirol Kliniken.Austria Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1753196 AbstractBackground: The foramen ovale (FO) plays a central role in fetal circulation. Prenatal FO closure or restriction is well-characterized in fetuses and in neonates with congenital heart defects, but is rarely described

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Efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis

Guanghong Li, Xiaoqun Du, Weibin Luo, Junhua Wei, Huiyi HuangHuadu District People’s Hospital of Guangzhou.China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1836276 AbstractObjective: To evaluate the efficacy and safety of bosentan-related therapy in neonates with persistent pulmonary hypertension of the newborn (PPHN).Methods: PubMed, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched from inception to March

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Clinical Factors Associated with Ventilator-Free Days in Newborns with Persistent Pulmonary Hypertension of the Newborn: A Retrospective Cohort Study in Thailand

Sirichan Larpnarongchai, Gunlawadee Maneenil, Anucha Thatrimontrichai Supaporn Dissaneevate, Manapat Praditaukrit, Pattima PakhathirathienPrince of Songkla University.Thailand Journal of Clinical MedicineJ Clin Med 2026; 15: DOI: 10.3390/jcm15114377 AbstractBackground/Objectives: Ventilator-free days (VFDs) are a useful composite measure to assess both survival and duration of mechanical ventilation in critically ill patients. This study aimed to determine the factors associated with

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Management of Hypoxemic Respiratory Failure in the Newborn During Therapeutic Hypothermia

Paulina Hume, Luna Khanal, Satyan Lakshminrusimha, Deepika SankaranUniversity of California, Davis.United States Clinics in PerinatologyClin Perinatol 2026; 53: 317-332DOI: 10.1016/j.clp.2026.02.008 AbstractTherapeutic hypothermia (TH) is the gold standard for the management of hypoxic ischemic encephalopathy (HIE) in newborns. Both hypoxia and TH may contribute to an increase in pulmonary vascular resistance (PVR), resulting in persistent pulmonary hypertension

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Advances in the Management of Persistent Pulmonary Hypertension of the Newborn

Emily Mooers, Satyan Lakshiminrusimha, G. Ganesh KonduriMedical College of Wisconsin and Children’s Wisconsin. University of California and UC Davis Children’s Hospital.United States Clinics in PerinatologyClin Perinatol 2026; 53: 297-316DOI: 10.1016/j.clp.2026.02.003 AbstractThis article details an integrated approach to optimize management strategies for hypoxemic respiratory failure and hemodynamic instability in persistent pulmonary hypertension of the newborn (PPHN). Even

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Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies

Srirupa Hari Gopal, Shweta Parmekar, Eugene Dempsey, Mohan PammiSSM Health Cardinal Glennon Children’s Hospital and Saint Louis University. Baylor College of Medicine and Texas Children’s Hospital.  University College Cork.United States and Ireland Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05164-4 AbstractWith improving survival, periviable neonates (≤25 weeks’ gestation) represent a dynamic, but under-studied population in neonatal care, with

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Physician Perspectives on the Utility of Pre/Post-Ductal Oxygen Saturation Monitoring in the Management of Neonates With Congenital Heart Disease

Beau Redwood, Adrian Tarca, Zac Dempsey, Rebecca Thomas, Cameron Seaman, Simon Erickson, Stephen Shipton, Deane YimPerth Children’s Hospital. Kids Research Institute Australia. Australia Heart Lung and CirculationHeart Lung Circ 2026; DOI: 10.1016/j.hlc.2025.12.028 AbstractBackground: Simultaneous pre/post-ductal oxygen saturation measurements are routinely performed in neonates with suspected congenital heart disease (CHD) however, there is significant variability in physician practices

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Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea

Ji Yoo Kim, Hyeon Jin Kim, Heeyoon Choi, Minji Kim, Jinseok Lee, Yong Sung Choi, Dong Keon YonKyung Hee University Medical Center and Kyung Hee University College of Medicine. South Korea Clinical and Experimental PediatricsClin Exp Pediatr 2026; DOI: 10.3345/cep.2025.02817 AbstractBackground: The impact of metabolic acidosis on short-term outcomes and mortality in very low birth weight infants

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