Animal Models of Pulmonary Vascular Disease and Therapy Archives - Page 9 of 20

Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling

Ling Tang, Xiao Zhou, Aili Guo, Lizhang Han, Silin PanJinan Central Hospital. Central Hosptial. Qilu Hospital. Qingdao Women and Children’s Hospital. Shandong University.China Cardiovascular ToxicologyCardiovasc Toxicol 2024;DOI: 10.1007/s12012-023-09822-5 AbstractHigh expression of the zinc finger X-chromosomal protein (ZFX) correlates with proliferation, aggressiveness, and development in many types of cancers. In the current report, we investigated the efficacy […]

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Rescuing lung development through embryonic inhibition of histone acetylation

Giangela Stokes, Zhuowei Li, Nicole Talaba, William Genthe, Maria B. Brix, Betty Pham, Mark D. Weihold, Gracia Sandok, Rebecca Hernan, Julia Wynn, Haiyang Tang, Diana M. Tabima, Allison Rodgers, Timothy A. Hacker, Naomi C. Chesler, Pan Zhang, Rabi Murad, Jason X.-J. Yuan, Yufeng Shen, Wendy K. Chung, David J. McCulleyUniversity of California, San Diego. University

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Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling

Hyunbum Kim, Yu Liu, Jiwon Kim, Yunhye Kim, Timothy Klouda, Sudeshna Fisch, Seung Han Baek, Tiffany Liu, Suzanne Dahlberg, Cheng-Jun Hu, Wen Tian, Xinguo Jiang, Kosmas Kosmas, Helen A Christou, Benjamin D. Korman, Sara O. Vargas, Joseph C. Wu, Kurt R. Stenmark, Vinicio de Jesus Perez, Mark R. Nicolls,Benjamin A. Raby, Ke Yuan European Molecular

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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension

Yi- Yin Tai, Qiujun Yu, Ying Tang, Wei Sun, Neil J. Kelly, Satoshi Okawa, Jingsi Zhao, Tae- Hwi Schwantes-An, Caroline Lacoux, Stephanie Torrino, Yassmin Al Aaraj, Wadih El Khoury, Vinny Negi, Mingjun Liu, Catherine G. Corey, Frances Belmonte, Sara O. Vargas, Brian Schwartz, Bal Bhat, B. Nelson Chau, Jason H. Karnes, Taijyu Satoh, Robert J.

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Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation

Jason T. Boehme, Xutong Sun, Qing Lu, Jubilee Barton, Xiaomin Wu, Wenhui Gong, Gary W. Raff, Sanjeev A. Datar, Ting Wang, Jeffrey R. Fineman, Stephen M. BlackUniversity of California San Francisco. Howard Wertheim College of Medicine and Florida International University. University of Arizona Health Sciences. University of California Davis. United States Nitric OxideNitric Oxide 2023;

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The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension

Yi‑Chia Wu, Wei‑Ting Wang, Ming‑Chun Yang, Yu‑Tsun Su, Jwu‑Lai Yeh, Jong‑Hau Hsu, Jiunn‑Ren WuKaohsiung Medical University Hospital and Kaohsiung Medical University. Kaohsiung Municipal Ta-Tung Hospital. E-Da Hospital and I-Shou University.Taiwan Biological ResearchBiol Res 2023; DOI: 10.1186/s40659-023-00480-z AbstractBackground: Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension Read More »

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C. U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwarzHarper Cancer Research Institute and University of Notre Dame.United States Circulation ResearchCirc Res 2023; 133: 704-719DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension (PH) is poorly

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Read More »

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao1, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene RabinovitchLucile Packard Children’s Hospital and Stanford University School of Medicine. University Medical Center

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Characterization of the congenital diaphragmatic hernia model in C57BL/6J fetal mice: a step toward lineage tracing experiments

Fabian Doktor, Rebeca Lopes Figueira Kasra Khalaj, Aizah Ijaz, Martin Lacher, Matisse Blundell, Lisa Antounians, Augusto ZaniThe Hospital for Sick Children and University of Toronto. University of Leipzig. Canada and Germany Pediatric Surgery InternationalPediatr Surg Int 2023; 39: DOI: 10.1007/s00383-023-05583-y AbstractPurpose: Lineage tracing is key to study the fate of individual cells and their progeny especially in

Characterization of the congenital diaphragmatic hernia model in C57BL/6J fetal mice: a step toward lineage tracing experiments Read More »