Animal Models of Pulmonary Vascular Disease and Therapy

Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension

Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. CornfieldStanford University.United States and Japan American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; DOI: 10.1152/ajplung.00428.2022 AbstractPulmonary arterial hypertension (PAH) is a disease characterized by increased vasoconstriction and vascular remodeling. Pulmonary artery smooth muscle cells (PASMC) highly […]

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Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension

Catherine E. Simpson, Anjira S. Ambade, Robert Harlan, Aurelie Roux, Susan Aja, David Graham, Ami A. Shah, Laura K. Hummers, Anna R. Humnes, Jane A. Leopold, Evelyn M. Horn, Erika S. Berman-Rosenzweig, Gabrielle Grunig, Michaela A. Aldred, John Barnard, Suzy A. A. Comhair, W. H. Wilson Tang, Megan Griffiths, Franz Rischard, Robert P. Frantz, Serpil

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Chemotherapy-induced pulmonary hypertension: role of alkylating agents

Benoît Ranchoux, Sven Günther, Rozenn Quarck, Marie-Camille Chaumais, Peter Dorfmüller, FabriceAntigny, Sébastien J. Dumas, Nicolas Raymond, Edmund Lau, Laurent Savale, Xavier Jaïs, Olivier Sitbon, Gérald Simonneau, Kurt Stenmark, Sylvia Cohen-Kaminsky, Marc Humbert, David Montani, Frédéric PerrosUniversité Paris-Sud and Hôpital de Bicêtre. Centre Chirurgical Marie Lannelongue. Assistance Publique des Hôpitaux de Paris. KU Leuven. University of

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Intact cord resuscitation in newborns with congenital diaphragmatic hernia: insights from a lamb model

Baptiste Teillet, Florian Manœuvrier, Céline Rougraff, Capucine Besengez, Laure Bernard, Anne Wojtanowski, Louise Ghesquieres, Laurent Storme, Sébastien Mur, Dyuti Sharma, Kévin Le DucHôpital Jeanne de Flandre and Centre Hospitalier Universitaire de Lille. France Frontiers on PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1236556 AbstractIntroduction: Congenital diaphragmatic hernia (CDH) is a rare condition characterized by pulmonary hypoplasia, vascular dystrophy, and pulmonary

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Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C.U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwartzHarper Cancer Research Institute. University of Notre Dame. Indiana University School of Medicine. United States Circulation ResearchCirc Res 2023; DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Read More »

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology

Chien-Nien Chen, Nabil Hajji, Fu-Chiang Yeh, Sunniyat Rahman, Souad Ali, John Wharton, Nicoleta Baxan, Lin Zhao, Chong-Yang Xie, Yi-Guan Chen, Maria G. Frid, Prakash Chelladurai, Soni Savai Pullamsetti, Kurt R. Stenmark, Martin R. Wilkins, Lan ZhaoImperial College London. Tri-Service General Hospital. University of Colorado. University Giessen Lung Centre. Max Planck Institute for Heart and Lung

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology Read More »

The small-molecule formyl peptide receptor biased agonist, Compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices

William R. Studley, Emma Lamanna, Katherine A. Martin, Claudia A. Nold-Perry, Simon G. Royce, Owen L. Woodman, Rebecca H. Ritchie, Cheng Xue Qin, Jane E. BourkeMonash University. Hudson Institute of Medical Research. Baker Heart and Diabetes Institute.Australia British Journal of PharmacologyBr J Pharmacol 2023; DOI: 10.1111/bph.16231 AbstractBackground and purpose: Pulmonary arterial hypertension (PAH), a rare but fatal

The small-molecule formyl peptide receptor biased agonist, Compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices Read More »

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph KnosallaDeutsches Herzzentrum der Charité. Charité-Universitätsmedizin Berlin. Freie Universität Berlin and Humboldt-Universität zu

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease Read More »

Outcomes of pregnancy in mice with pulmonary hypertension induced by Hypoxia/SU5416

Yang Liu, Jing Deng, Yichen Zhao, Kemin Liu, Wenbo Zhang, Qiang Wang, Jiangang Wang, Chunmei PiaoBeijing Anzhen Hospital Affiliated to Capital Medical University. Yanbian University. Beijing Institute of Heart Lung and Blood Vessel Diseases. China Biochemical and Biophysical Research CommunicationsBiochem Biophys Res Commun 2023; 669: 128-133DOI: 10.1016/j.bbrc.2023.05.051 AbstractBackground: Pulmonary hypertension (PH) seriously affects the health of patients.

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Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries

Yan Bai, Guang Li, Laiming Yung, Paul B. Yu, Xingbin AiMassachusetts General Hospital and Harvard Medical School. Brigham and Women’s Hospital. Renmin Hospital and Wuhan University. United States and China American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L114-L124DOI: 10.1152/ajplung.00293.2022 AbstractIntrapulmonary arteries located in the proximal lung

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