Animal Models of Pulmonary Vascular Disease and Therapy

Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study

Jian-Jian Yu, Jian-Ge Han, Yi Tan, Jian-Xiang Xu, Amanda LeBlanc, Bradley B. Keller, Jiapeng Huang, Lu CaiUniversity of Louisville School of Medicine. Tianjin University Chest Hospital. Cincinnati Children’s Heart Institute and University of Cincinnati. United States and China World Journal of DiabetesWorld J Diabetes 2025; 13: DOI: 10.4239/wjd.v16.i10.109526 AbstractBackground: Diabetes has become a widespread metabolic disease affecting […]

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Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension

Shyam Thapa, Poonam Sarkar, M. Waleed Gaber, Roberto Barrios, Madhulata Chauhan, Chandrasekhar Yallampalli, Binoy ShivannaTexas Children’s Hospital and Baylor College of Medicine. Houston Methodist HospitalUnited States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00234.2025 AbstractBronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH) or BPD-PH is a lung

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Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

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Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease

Melissa J. Lucero, Christina Lisk, Delaney Swindle, Francesca Cendali, Saini Setua, Kiruphagaran Thangaraju, Alamzeb Khan, David I. Pak, Quintin O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Saqib Khan, Nishant Rana, Natalie Westover, Pavel Davizon-Castillio, Gemlyn George, Kathryn Hassell, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Christy Niemeyer, Pedro Cabrales, Andre Palmer, Angelo D’Alessandro, Paul W. Buehler,

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The Effect of Microvascular Remodeling on Fluid Dynamics in the Pressure Overloaded Right Ventricle

Ilham Essafri, Kenzo Ichimura, Dunbar Ivy, Kurt R. Stenmark, Helena A. Turton, Laura L. Pyle, Edda Spiekerkoetter, Vitaly O. KheyfetsUniversity of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. Stanford University, Stanford. United States American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2025; DOI: 10.1152/ajpheart.00147.2025 AbstractRight ventricular (RV) failure, a major

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Microvascular preservation & cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension

Michael A. Smith, Eleana S. Guardado, Jason Boehme, Sanjeev A. Datar, Emin Maltepe, Naveen Swami, Gary W Raff, Aaron Bodansky, Prakash Chelladurai, Joseph Moreno, Annelise Prince, Nevan Powers, Guo N. Huang, Vinicio de Jesus Perez, Jeffrey R. FinemanUniversity of California, San Francisco. Stanford University. United States American Journal of Physiology Heart and Circulatory PhysiologyAm J

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Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension

Jun-Zhuo Shi, Yong-Jian Zhu, Meng-Jie Zhang, Yi Yan, Lu-Ling Zhao, Hong-Da Zhang, Yan Liu, Wen-Hui Wu, Zhe Cheng, Chun-Guang Qiu, Jie-Jian Kou, Yun-Feng Zhou, Xiao-Bin Pang, Ji-Wang Chen, Xin-Mei Xie, Yang-Yang He, Zhi-Cheng JingHuaihe Hospital and Henan University. First Affiliated Hospital of Zhengzhou University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao

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Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia

Kel Vin Woo, Philip T. Levy, Carla J. Weinheimer, Amanda L. Hauck, Aaron Hamvas, David M. Ornitz, Attila Kovacs, Gautam K. SinghWashington University School of Medicine. Boston Children’s Hospital, Department of Pediatrics and Harvard Medical School. Ann and Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. Children’s Hospital Michigan

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SUL-150 Limits Vascular Remodeling and Ventricular Failure in Pulmonary Arterial Hypertension

Lysanne M. Jorna, Dalibor Nakládal, Johannes N. van Heuveln, Diederik E. van der Feen, Quint A. J. Hagdorn, Guido P. L. Bossers, Annemieke van Oosten, Michel Weij, Ludmila Tkáciková, Sona Tkáciková, Robert H. Henning, Martin C. Harmsen, Rolf M. F. Berger, Guido KrenningUniversity Medical Center Groningen, University of Groningen. Comenius University Bratislava. University of Heidelberg.

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IDO-1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension

Zongye Cai, Ly Tu, Siyu Tian, Lin Deng, Yahong Fu, Carole Phan, Thierry P. P. van den Bosch, Karin Tran‐Lundmark, Bence M. Nagy, Horst Olschewski, Xiaoxuan Li, Sihao Wang, Danan Wang, Yi Yan, Lijun Fu, Karin A. Boomars, Christophe Guignabert, Daphne MerkusSecond Affiliated Hospital and Zhejiang University School of Medicine. Erasmus MC and University Medical Center. Pathophysiologie et Innovation Thérapeutique (HPPIT) and Université Paris-Saclay, School of Medicine. Eighth Affiliated Hospital of Sun Yat-sen University. Lund University and Skane University Hospital. Medical University

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