Animal Models of Pulmonary Vascular Disease and Therapy

TCF7 enhances pulmonary hypertension by boosting stressed natural killer cells and their interaction with pulmonary arterial smooth muscle cells

Li-Wei Wu, Min Chen, Dai-Ji Jiang, Chen-Yu Jiang, Yi-Wei Liu, Bei Feng, Chen-Fei Shi, Xu Huang, Xu Zhang, Xiao-He Xu, Xing-Liang Zhou, Yi Shen, Tian-Yu Liu, Lin-Cai Ye, Yang-Yang He, Hao Zhang, Yi YanShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Second Affiliated Hospital, Yuying Children’s Hospital […]

TCF7 enhances pulmonary hypertension by boosting stressed natural killer cells and their interaction with pulmonary arterial smooth muscle cells Read More »

Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression

Shawyon P. Shirazi, Nicholas M. Negretti, Christopher S. Jetter, Alexandria L. Sharkey, Shriya Garg, Meghan E. Kapp, Devan Wilkins, Gabrielle Fortier, Saahithi Mallapragada, Nicholas E. Banovich, Laurie C. Eldredge, Gail H. Deutsch, Christopher V. E. Wright, David B. Frank, Jonathan A. Kropski, Jennifer M. S. SucreVanderbilt University Medical Center and Vanderbilt University. Translational Genomics Research

Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression Read More »

Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

Bin Liu, Dan Yi, Shuai Li, Karina Ramirez, Xiaomei Xia, Yanhong Cao, Hanqiu Zhao, Ankit Tripathi, Shenfeng Qiu, Mrinalini Kala, Ruslan Rafikov, Haiwei Gu, Vinicio de jesus Perez, Sarah-Eve Lemay, Christopher C. Glembotski, Kenneth S. Knox, Sebastien Bonnet, Vladimir V. Kalinichenko, You-Yang Zhao, Michael B. Fallon, Olivier Boucherat, Zhiyu DaiCollege of Medicine-Phoenix and University of Arizona. Washington University School of Medicine in St. Louis. Guangzhou Medical University. Indiana University College of Medicine. Arizona State University. Stanford University. Laval University. Phoenix Children’s Hospital. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.United

Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension Read More »

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3

Bum-Yong Kang, Jiwoong Choi, Victor Tseng, Yutong Zhao, Jing Zhao, Robert S. Stearman, Wilbur A. Lam, Viranuj Sueblinvong, Benjamin T. Kopp, Michael J. Passineau, Changwon Park, John Lister, Raymond J. Benza, Andrew J. JangEmory University School of Medicine. Atlanta Veterans Healthcare System. University of Kansas School of Medicine and University of Kansas. Ansible Health. Ohio

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3 Read More »

Pulmonary artery-targeted low-dose metformin-loaded nanocapsules safely improve pulmonary arterial hypertension in rats

Ayako Chida-Nagai, Naoki Masaki, Hiroki Sato, Tatsuya Kato, Emi Takakuwa, Yoshihiro Matsuno, Atsushi Manabe, Atsuhito TakedaHokkaido University Hospital. Tokyo Women’s Medical University. Tohoku University Graduate School of Medicine. Oita University and Oita University Hospital.Japan Frontiers in PediatricsFront Pediatr 2025; 16: DOI: 10.3389/fphar.2025.1577570 AbstractIntroduction: Pulmonary arterial hypertension (PAH) remains a challenge to tackle despite various available medications. Metformin,

Pulmonary artery-targeted low-dose metformin-loaded nanocapsules safely improve pulmonary arterial hypertension in rats Read More »

Cyclopamine Attenuates Pulmonary Arterial Hypertension Development: Implications of Hedgehog Signaling Involvement for the Pathophysiology

Makito Sakurai, Susumu Hosakawa, Yohei Yamaguchi, Susumu Kirimura, Kensuke Ihara, Kenichi Ohashi, Tetsushi Furukawa, Tetsuo Sasano, Kenichi Kashimada, Taku IshiiInstitute of Science Tokyo. Japanese Red Cross Musashino Hospital.  National Center for Child Health and Development. Japan Federation of American Societies for Experimental Biology JournalFASEB J 2025; 39: DOI: 10.1096/fj.202403350R AbstractPulmonary arterial hypertension (PAH) is one of

Cyclopamine Attenuates Pulmonary Arterial Hypertension Development: Implications of Hedgehog Signaling Involvement for the Pathophysiology Read More »

Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation

Jason T. Boehme, Sanjeev A. Datar, Xutong Sun, Wenhui Gong, Qing Lu, Jamie Soto, Michael A. Smith, Alejandro E. Garcia-Flores, Gary W. Raff, TingWang, Emin Maltepe, Stephen M. Black, Jeffrey R. FinemanUniversity of California San Francisco. Florida International University. University of California Davis. United States Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-99062-0 AbstractIn patients with congenital

Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation Read More »

Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice

Yi Jin, Bernadette Chen, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00202.2024 AbstractBronchopulmonary dysplasia (BPD) is a common chronic lung disease in pediatrics. Neonatal mice placed in hyperoxia (85% oxygen, HYP) develop lung injury

Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice Read More »

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells

Manivannan Yegambaram, Marissa D. Pokharel, Xutong Sun, Qing Lu, Jamie Soto, Saurabh Aggarwal, Emin Maltepe, Jeffery R. Fineman, Ting Wang, Stephen M. BlackFlorida International University. University of California San Francisco. United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26083815 AbstractIt is well-established that mitochondrial dysfunction plays a critical role in the

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells Read More »

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. NozikUniversity of Colorado, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of Nebraska Medical Center.United States American Journal of

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia Read More »

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