Animal Models of Pulmonary Vascular Disease and Therapy

Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat

Bingbing Ye, Danyan Su, Yuqin Huang, Dongli Liu, Yanyun Huang, Suyuan Qin, Cheng Chen, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University.China Clinical and Experimental HypertensionClin Exp Hypertens 2025; 47: DOI: 10.1080/10641963.2025.2583193 AbstractThis study was designed to elucidate the role of circPcmtd1 in regulating pulmonary artery smooth muscle cells (PASMCs) proliferation and migration, through the HSP90AB1/AKT […]

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Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model

Jonathan Hyde, Michael A. Smith, Naveen Swami, John H. Hwang, Yenchun Chao, Jason Boehme,Gary W. Raff, Casper Noah Nilsson, Wenhui Gong, Gail H. Deutsch, Eric G. Johnson, Ting Wang,Stephen M. Black, Sanjeev A. Datar, Emin Maltepe, Jeffrey R. FinemanUniversity of California, San Francisco. Copenhagen University Hospital. University of Washington. University of California, Davis School of

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De novo variant in RING finger protein 213 causes systemic vasculopathy

Ayako Kashimada, Tomoko Mizuno, Eriko Tanaka, Susumu Hosokawa, Tomohiro Udagawa, Yuichi Hiraoka, Keisuke Uchida, Tomohiro Morio, Kenjiro Kosaki, Masatoshi TakagiInstitute of Science Tokyo. Kyorin University. Keio University.Japan Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.190094 AbstractSystemic arterial stenosis, including moyamoya disease (MMD) and middle aortic syndrome (MAS), is a rare condition of unclear etiology. MMD

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Establishment of a neonatal rat model of sequential hyperoxic hypoxia to recapitulate clinical progression of bronchopulmonary dysplasia-associated pulmonary hypertension

Dan Wang, Siqi Hu, Jingke Cao, Haoqin Fan, Ye Ma, Fan Yang, Changgen Liu, Shanghong Tang, Zhichun Feng, Yunbin Xiao, Qiuping LiAffiliated Children’s Hospital of Xiangya School of Medicine and Central South University (Hunan Children’s Hospital). Seventh Medical Center of PLA General Hospital. Second School of Clinical Medicine and Southern Medical University. Shenzhen Baoan Women’s

Establishment of a neonatal rat model of sequential hyperoxic hypoxia to recapitulate clinical progression of bronchopulmonary dysplasia-associated pulmonary hypertension Read More »

Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study

Jian-Jian Yu, Jian-Ge Han, Yi Tan, Jian-Xiang Xu, Amanda LeBlanc, Bradley B. Keller, Jiapeng Huang, Lu CaiUniversity of Louisville School of Medicine. Tianjin University Chest Hospital. Cincinnati Children’s Heart Institute and University of Cincinnati. United States and China World Journal of DiabetesWorld J Diabetes 2025; 13: DOI: 10.4239/wjd.v16.i10.109526 AbstractBackground: Diabetes has become a widespread metabolic disease affecting

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Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension

Shyam Thapa, Poonam Sarkar, M. Waleed Gaber, Roberto Barrios, Madhulata Chauhan, Chandrasekhar Yallampalli, Binoy ShivannaTexas Children’s Hospital and Baylor College of Medicine. Houston Methodist HospitalUnited States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00234.2025 AbstractBronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH) or BPD-PH is a lung

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Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

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Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease

Melissa J. Lucero, Christina Lisk, Delaney Swindle, Francesca Cendali, Saini Setua, Kiruphagaran Thangaraju, Alamzeb Khan, David I. Pak, Quintin O’Boyle, Shuwei Lu, Robert Tolson, Seth Zaeske, Saqib Khan, Nishant Rana, Natalie Westover, Pavel Davizon-Castillio, Gemlyn George, Kathryn Hassell, Rachelle Nuss, Nathan Brinkman, Thomas Gentinetta, Christy Niemeyer, Pedro Cabrales, Andre Palmer, Angelo D’Alessandro, Paul W. Buehler,

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The Effect of Microvascular Remodeling on Fluid Dynamics in the Pressure Overloaded Right Ventricle

Ilham Essafri, Kenzo Ichimura, Dunbar Ivy, Kurt R. Stenmark, Helena A. Turton, Laura L. Pyle, Edda Spiekerkoetter, Vitaly O. KheyfetsUniversity of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. Stanford University, Stanford. United States American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2025; DOI: 10.1152/ajpheart.00147.2025 AbstractRight ventricular (RV) failure, a major

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Microvascular preservation & cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension

Michael A. Smith, Eleana S. Guardado, Jason Boehme, Sanjeev A. Datar, Emin Maltepe, Naveen Swami, Gary W Raff, Aaron Bodansky, Prakash Chelladurai, Joseph Moreno, Annelise Prince, Nevan Powers, Guo N. Huang, Vinicio de Jesus Perez, Jeffrey R. FinemanUniversity of California, San Francisco. Stanford University. United States American Journal of Physiology Heart and Circulatory PhysiologyAm J

Microvascular preservation & cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension Read More »

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