Animal Models of Pulmonary Vascular Disease and Therapy

Pneumonectomy combined with SU5416 or monocrotaline pyrrole does not cause severe pulmonary hypertension in mice

Xiao-Qing Sun, Timothy Klouda, Suzanne Barnasconi, Ingrid Schalij, Janne Schwab, Anders Hammer Nielsen-Kudsk, Julie Sørensen Axelsen, Asger Andersen, Jurjan Aman, Frances S. de Man, Harm Jan Bogaard, Ke Yuan, Keimei YoshidaAmsterdam UMC. Boston Children’s Hospital. Aarhus University Hospital.Netherlands, United States and Denmark American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell […]

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Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension

Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Kevin Nolan, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. GrahamUniversity of California, San Francisco and Zuckerberg San Francisco General Hospital. University of Colorado Anschutz Medical Campus. United States Frontiers in ImmunologyFront Immunol 2024; DOI: 10.3389/fimmu.2024.1372957 AbstractBackground: Schistosomiasis

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3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension

Kenzo Ichimura, Mario Boehm, Adam M. Andruska, Fan Zhang, Katharina Schimmel, Spencer Bonham, Angela Kabiri, Vitaly O. Kheyfets, Shoko Ichimura, Sushma Reddy, Yuqiang Mao, Tianyi Zhang, Gordon Wang, Everton J. Santana, Xuefei Tian, Ilham Essafri, Ryan Vinh, Wen Tian, Mark R. Nicolls, Shin Yajima, Yasuhiro Shudo, John W. McArthur, Y. Joseph Woo, Ross J. Metzger,

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Effect of Estrogen Receptor Alpha on Cardiopulmonary Adaptation to Chronic Developmental Hypoxia in a Rat Model

Nicholas T. Severyn, Patricia Esparza, Huanling Gao, Elizabeth A. Mickler, Marjorie E. Albrecht, Amanda Fisher, Bakhtiyor Yakubov, Todd G. Cook, James E. Slaven, Avram D. Walts, Robert S. Tepper, Tim LahmUniversity of Kentucky. Indiana University – Purdue University Indianapolis. University of Colorado. National Jewish Health.United States American Journal of Physiology Lung Cellular and Respiratory PhysiologyAm

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A neonatal rat model of pulmonary vein stenosis

Debao Li, Lisheng Qiu, Haifa Hong, Hao Chen, Peibin Zhao, Yingying Xiao, Hao Zhang, Qi Sun, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University. Second Affiliated Hospital and Yuying Children’s Hospital and Wenzhou Medical University.China Cell and BioscienceCell Biosci 2023; 13:DOI: 10.1186/s13578-023-01058-8 AbstractObjectives: Pulmonary vein stenosis (PVS), one of the most challenging clinical problems in

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Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

Haiyang Tang, Akash Gupta, Seth A. Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R. Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A. Warfel, Louise Hecker, Sumegha Mitra, Anna W. Coleman, Katie A. Lutz, Michael W. Pauciulo, Yen-Chun Lai, Ali Javaheri,

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Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension

Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. StenmarkUniversity of Colorado School of Medicine. University of California San Francisco. Zuckerberg San Francisco General Hospital.United States Frontiers in ImmunologyFront Immunol 2024; 15: DOI: 10.3389/fimmu.2024.1372959 AbstractIntroduction: Hypoxia

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension Read More »

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells Read More »

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension

Michael G. Katz, Yoav Hadas, Nataly Shtraizent, Shana Ravvin, Jeko M. Madjarov, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Wake Forest School of Medicine. United States Methods in Molecular BiologyMethods Mol Biol 2024; 2803: 173-185DOI: 10.1007/978-1-0716-3846-0_13 AbstractPulmonary hypertension (PH) is a chronic and progressive disorder characterized by elevated mean pulmonary arterial pressure, pulmonary vascular remodeling,

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension Read More »

A Bioinformatic Algorithm based on Pulmonary Endoarterial Biopsy for Targeted Pulmonary Arterial Hypertension Therapy

Abraham Rothman, David Mann, Jose A. Nunez, Reinhardt Tarmidi, Humberto Restrepo, Valeri Sarukhanov, Roy Williams, William N. EvansChildren’s Heart Center Nevada. Kirk Kerkorian School of Medicine at UNLV. Vascular Biosciences. University of California, Santa Barbara. University of California, San Diego.United States Open Respiratory Medicine JournalOpen Respir Med J 2023; DOI: 10.2174/18743064-v17-230927-2023-9 AbstractBackground: Optimal pharmacological therapy for pulmonary

A Bioinformatic Algorithm based on Pulmonary Endoarterial Biopsy for Targeted Pulmonary Arterial Hypertension Therapy Read More »

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