Animal Models of Pulmonary Vascular Disease and Therapy Archives - Page 17 of 20

Metabolic Reprogramming of the Right Ventricle and Pulmonary Arteries in a Flow-Associated Pulmonary Arterial Hypertension Rat Model

Dongli Liu, Suyuan Qin, Danyan Su, Kai Wang, Yanyun Huang, Yuqin Huang, Yusheng PangThe First Affiliated Hospital of Guangxi Medical University. The First Affiliated Hospital of Wenzhou Medical University.China American Chemical Society OmegaACS Omega 2021; 7: 1273-1287DOI: 10.1021/acsomega.1c05895 AbstractPulmonary arterial hypertension (PAH) is a complex devastating disease relevant to remarkable metabolic dysregulation. Although various research studies […]

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Identification of the Key Pathways and Genes in Hypoxia Pulmonary Arterial Hypertension Following Intrauterine Growth Retardation

Weifen Zhu, Ziming Zhang, Weiwei Gui, Zheng Shen, Yixin Chen, Xueyao Yin, Li Liang, Lin LiThe Affiliated Sir Run Run Shaw Hospital, Children’s Hospital and The First Affiliated Hospital of Zhejiang University.China Frontiers in Molecular BiosciencesFront Mol Biosci 2022; DOI: 10.3389/fmolb.2022.789736 AbstractHigh-throughput sequencing and weighted gene co-expression network analysis (WGCNA) were used to identify susceptibility modules

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Identification of SOX2 Interacting Proteins in the Developing Mouse Lung With Potential Implications for Congenital Diaphragmatic Hernia

Kim A. A. Schilders, Gabriëla G. Edel, Evelien Eenjes, Bianca Oresta, Judith Birkhoff, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Jeroen A. A. Demmers, Raymond Poot, Rene M. H. Wijnen, Dick Tibboel and Robbert J. RottierErasmus Medical Center and Sophia Children’s Hospital. Democritus University of Thrace. Netherlands and Greece Frontiers in PediatricsFront

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Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia

Tsering Stobdan, Pritesh P. Jain, Mingmei Xiong, Vineet Bafna, Jason X.-J. Yuan, Gabriel G. HaddadUniversity of California San Diego. Rady Children’s Hospital.United States Human Molecular GeneticsHum Mol Genet 2022; 31: 1130-1140DOI: 10.1093/hmg/ddab291 AbstractThe molecular mechanisms leading to high-altitude pulmonary hypertension (HAPH) remains poorly understood. We previously analyzed the whole genome sequence of Kyrgyz highland population and

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Hepatoma-derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

Jun Yang, Anjira S. Ambade, Melanie Nies, Megan Griffiths, Rachel Damico, Dhananjay Vaidya, Stephanie Brandal, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, William C. Nichols, Eric D. Austin, Dunbar Ivy, Paul M. Hassoun, Allen D. EverettJohns Hopkins University. Vagelos College of Physicians and Surgeons Columbia University. University of Cincinnati College of Medicine and

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Dichotomous role of integrin-β5 in lung endothelial cells

Neil Blanchard, Patrick A. Link, Daniela Farkas, Brennan Harmon, Jaylen Hudson, Srimathi Bogamuwa, Bryce Piper, Kayla Authelet, Carlyne D. Cool, Rebecca L. Heise, Robert Freishtat, Laszlo FarkasUniversity of Virginia. Ohio State University. Children’s National Health System. University of Colorado. Virginia Commonwealth University.United States Pulmonary CirculationPulm Circ 2022; DOI: 10.1002/pul2.12156 AbstractPulmonary arterial hypertension (PAH) is a progressive,

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Seven-day in vivo testing of a novel, low-resistance, pumpless pediatric artificial lung for long-term support

Brian P. Fallon, Alex J. Thompson, Aaron R. Prater, Skylar Buchan, Trevor Alberts, Mark Hoenerhoff, Alvaro Rojas-Pena, Robert H. Bartlett, Ronald B. HirschlUniversity of Michigan Medical School and Michigan Medicine.United States Journal of Pediatric SurgeryJ Pediatr Surg 2022; 57: 614-623DOI: 10.1016/j.jpedsurg.2022.07.006 AbstractIntroduction: For children with end-stage lung disease that cannot wean from extracorporeal life support (ECLS), a

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Effects of uteroplacental insufficiency on cardiac development in growth-restricted newborn rats

Hsiu-Chu Chou, Chung-Ming ChenTaipei Medical University.Taiwan Journal of the Developmental Origins of Health and DiseaseJ Dev Orig Health Dis 2023; 14: 272-278DOI: 10.1017/S2040174422000575 AbstractFetal growth restriction (FGR) is associated with reduced cardiac function in neonates. Uteroplacental insufficiency (UPI) is the most common cause of FGR. The mechanisms underlying these alterations remain unknown. We hypothesized that UPI

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