Animal Models of Pulmonary Vascular Disease and Therapy

Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model

R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R. […]

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Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema

Alicia B. Byrne, Pascal Brouillard, Drew L. Sutton, Jan Kazenwadel, Saba Montazaribarforoushi, Genevieve A. Secker, Anna Oszmiana, Milena Babic, Kelly L. Betterman, Peter J. Brautigan, Melissa White, Sandra G. Piltz, Paul Q. Thomas, Christopher N. Hahn, Matthias Rath, Ute Felbor, G. Christoph Korenke, Christopher L. Smith, Kathleen H. Wood, Sarah E. Sheppard, Denise M. Adams,

Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema Read More »

Hyperoxia Disrupts Lung Lymphatic Homeostasis in Neonatal Mice

Nithyapriya Shankar, Shyam Thapa, Amrit Kumar Shrestha, Poonam Sarkar, M. Waleed Gaber, Roberto Barrios, Binoy ShivannaTexas Children’s Hospital and Baylor College of Medicine. Houston Methodist Hospital.United States AntioxidantsAntioxidants 2023; DOI: 10.3390/antiox12030620 AbstractInflammation causes bronchopulmonary dysplasia (BPD), a common lung disease of preterm infants. One reason this disease lacks specific therapies is the paucity of information on

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Hepatic factor may not originate from hepatocytes

Monica Merbach, Ramani Ramchandran, Andrew D. SpearmanMedical College of Wisconsin and Children’s Wisconsin.United States Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; DOI: 10.3389/fcvm.2022.999315 AbstractPulmonary arteriovenous malformations (PAVMs) develop universally in patients with univentricular congenital heart disease. They are believed to form due to lack of an unidentified factor from hepatocytes that perfuses the lungs to maintain

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The adult heart requires baseline expression of the transcription factor Hand2 to withstand right ventricular pressure overload

Raquel F. Videira, Anne-Marie C. Koop, Lara Ottaviani, Ella M. Poels, Jordy M. M. Kocken, Cristobal Dos Remedios, Pedro Mendes-Ferreira, Kees W. Van De Kolk, Gideon J. Du Marchie Sarvaas, Andre´ Lourenc, Aida Llucia`-Valldeperas, Diana S. Nascimento, Leon J. De Windt, Frances S. DeMan, Ineˆs Falc~ao-Pires, Rolf M. F. Berger, Paula A. da Costa MartinsMaastricht

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Hypoxic preconditioning improves the survival and pro-angiogenic capacity of transplanted human umbilical cord mesenchymal stem cells via HIF-1α signaling in a rat model of bronchopulmonary dysplasia

Chang Hao, Jingyi You, Huijun Qiu, Ou Zhou, Jiang Liu, Wenjing Zou, Ke Yeng, Zhou Fu, Lin ZouChildren’s Hospital of Chongqing Medical University. China Biochemical and Biophysical Research CommunicationsBiochem Biophys Res Commun 2022; 605: 111-118DOI: 10.1016/j.bbrc.2022.03.044 AbstractBronchopulmonary dysplasia (BPD) is a serious chronic respiratory disease that predominates in the neonatal period. Currently, efficacious and effective specific

Hypoxic preconditioning improves the survival and pro-angiogenic capacity of transplanted human umbilical cord mesenchymal stem cells via HIF-1α signaling in a rat model of bronchopulmonary dysplasia Read More »

Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants

Jason C. Lao, Christine B. Bui, Merrin A. Pang, Steven X. Cho, Ina Rudloff, Kirstin Elgass, Jan Schroder, Anton Maksimenko, Niamh E. Mangan, Malcolm R. Starkey, Elisabeth M. Skuza, Yu B. Y. Sun, Friederike Beker, Clare L. Collins, Omar F. Kamlin, Kai Konig, Atul Malhotra, Kenneth Tan, Chritiane Theda, Morag J. Young, Catriona A. McLean,

Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants Read More »

Thrombospondin-1 Plays a Major Pathogenic Role in Experimental and Human Bronchopulmonary Dysplasia

Brittany Ann Ruschkowski, Yousef Esmaeil, Kate Daniel, Chantel Gaudet, Behzad Yeganeh, David Grynspan, Robert P. JankovChildren’s Hospital of Eastern Ontario Research Institute. University of Ottawa.Canada American Journal of Respiratory and Critical Care MedicineAm J Respir Crit Care Med 2022; 205: 685-699DOI: 10.1164/rccm.202104-1021OC AbstractRationale: Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective

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Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis

Fan Hu, Hanmin Liu, Chuan Wang, Hanwen Li, Lina QiaoWest China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, and West China Hospital of Stomatology. Sichuan University. China Experimental and Therapeutic MedicineExp Ther Med 2022; 23: DOI: 10.3892/etm.2021.11031 AbstractThe biological processes of pulmonary artery vascular smooth muscle cells (PA-SMCs)

Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis Read More »

Assessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia

Dandan Zhu, Mirja Krause, Tamara Yawno, Gina D. Kusuma, Renate Schwab, Mehri Barabadi, Amina S. Maleken, Siow T. Chan, Rod Hunt, David Greening, Euan M. Wallace, Rebecca LimHudson Institute of Medical Research. Monash University. La Trobe Institute for Molecular Science and La Trobe University. University of Melbourne.Australia Stem Cell Research and TherapyStem Cell Res Ther

Assessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia Read More »

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