Animal Models of Pulmonary Vascular Disease and Therapy

Active response of pulmonary veins to distention of a single pulmonary vein in intact dogs

Albert L. Hyman, G. SanchezTulane University School of Medicine.United States Journal of Laboratory and Clinical MedicineJ Lab Clin Med 1969; 73: 476-485DOI: Not Available AbstractAbstract Not Available CategorySegmental Pulmonary Venous Disease. Without a Focus on Pulmonary HypertensionAnimal Models of Pulmonary Vascular Disease and Therapy Age Focus: No Age-Related Focus Fresh or Filed Publication: Filed (PHiled). […]

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Progression of vascular remodeling in pulmonary vein obstruction

Naoki Masaki, Osamu Adachi, Shintaro Katahira, Yuriko Saiki, Akira Horii, Shunsuke Kawamoto, Yoshikatsu SaikiTohoku University Graduate School of Medicine. Japan Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2020; 160: 777-790.e5DOI: 10.1016/j.jtcvs.2020.01.098 AbstractObjectives: Pulmonary vein obstruction (PVO) frequently occurs after repair of total anomalous pulmonary vein connection with progression of intimal hyperplasia from the anastomotic site

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Serum Metabolomic Profile in Hypoxia-Induced Pulmonary Hypertension Mice after C75 Treatment

Shun Chen, Shujia Lin, Wei Liu, Qiuping Lin, Yi Yang, Qingzhu Qiu, Yanfang Zong, Tingting Xiao, Cuilan Hou, Lijian XieShanghai Children’s Hospital and Shanghai Jiao Tong University School of Medicine. NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology. JinShan Hospital and Fudan University.China Frontiers in Bioscience Landmark EditionFront Biosci (Landmark Ed) 2023; 28:

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Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study

Jay I. LaBourene, John G. Coles, Dorothy J. Johnson, Arun Mehra, Fred W. Keeley, Marlene RabinovitchHospital for Sick Children.Canada Circulation ResearchCirc Res 1990; 66: 438-456DOI: 10.1161/01.res.66.2.438 AbstractWe created an animal model to understand better the pathogenesis and underlying mechanism of progressive central pulmonary venous (PV) obstruction, a condition not amenable to current therapy. Twenty piglets underwent

Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study Read More »

CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension

Abraham Rothman, Humberto Restrepo, William N. Evans, Valeri Sarukhanov, David MannUniversity of Nevada Las Vegas. Vascular BioSciences.United States Open Respiratory Medicine JournalOpen Respir Med J 2023; DOI: 10.2174/18743064-v17-e230404-2022-19 AbstractBackground: Despite the approval of several medications for pulmonary hypertension, morbidity and mortality are unacceptably high. Systemic hypotension may limit the use of pulmonary hypertension medications.Objectives: This study aimed to

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Ambulatory Seven-Day Mechanical Circulatory Support in Sheep Model of Pulmonary Hypertension and Right Heart Failure

Rei Ukita, Yatrik J. Patel, W. Kelly Wu, Sean A. Francois, Michael Cortelli Jr, Carl A. Johnson Jr, Nancy Cardwell, Jennifer R. Talackine, John W. Stokes, William Grogan, Meredith Mentz, Kaitlyn M. Tracy, Timothy R. Harris, William Tucker, Elizabeth Simonds, Caitlin T. Demarest, Keith E. Cook, David J. Skoog, Erika B. Rosenzweig, Matthew BacchettaVanderbilt University

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Advances in the research of sulfur dioxide and pulmonary hypertension

Xin Liu, He Zhou, Hongsheng Zhang, Hongfang Jin, Yan HeBeijing Anzhen Hospital and Capital Medical University. Tulane University School of Medicine. Peking University First Hospital and Peking University.China and United States Frontiers in PharmacologyFront Pharmacol 2023; 14:DOI: 10.3389/fphar.2023.1282403 AbstractPulmonary hypertension (PH) is a fatal disease caused by progressive pulmonary vascular remodeling (PVR). Currently, the mechanisms underlying

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Technical problems in lung allotransplantation. Causes of pulmonary venous outflow obstruction

Gary H. Stevens, Decio M. Rangel, Yozo Yakeishi, Eric W. FonkalsrudUCLA School of Medicine.United States Archives of SurgeryArch Surg 1969; 99: 506-512DOI: 10.1001/archsurg.1969.01340160086020 AbstractExperience in this laboratory with approximately 100 canine and primate lung allotransplantation operations over the past 18 months has made clear the fact that technical problems are the cause of a large number

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Observations on Resistance to the Flow of Blood to and from the Lungs

Richmond L. Moore, Carl A. L. BingerHospital of The Rockefeller Institute for Medical ResearchUnited States Journal of Experimental MedicineJ Exp Med 1927; 45: 655-671DOI: 10.1084/jem.45.4.655 Abstract1. Embolism of pulmonary arterioles and capillaries produced by the intravenous injection of starch grains results in a dilatation of the pulmonary artery and the right chambers of the heart. This

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Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension

Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. CornfieldStanford University.United States and Japan American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; DOI: 10.1152/ajplung.00428.2022 AbstractPulmonary arterial hypertension (PAH) is a disease characterized by increased vasoconstriction and vascular remodeling. Pulmonary artery smooth muscle cells (PASMC) highly

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