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The Role of Machine Learning and Artificial Intelligence in Drug Discovery and Clinical Care of Pulmonary Hypertension

Evelyne Bischof, Chaim Haber, Niklas LidströmerShanghai University of Medicine and Health Sciences. Sheba Medical Center, Grey School of Medicine and Tel Aviv University. University of Copenhagen. Karolinska Institutet. China, Israel, Denmark and Sweden Heart Failure ClinicsHeart Fail Clin 2026; 22: 361-370DOI: 10.1016/j.hfc.2026.02.009 AbstractPulmonary hypertension (PH) is a severe and oftentimes fatal disease with a high degree […]

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An Ancient Founder GDF2 Variant Potentially Causes Semi-Dominant Non-Syndromic Pulmonary Arterial Hypertension

Abdullah Aldalaan, Seba Nadeef, Ebtissal Khouj, Fayez Alahmadi, Bayan Aljamal, Noura Alturaif, Nadeen Alharbi, Firdous Abdulwahab, Mashael Alqahtani, Fatima Alzubi, Omar Abuyousef, Mais O. Hashem, Hamdiah Zaytoun, Hanadi Alhamoud, Tarfa Alshidi, Amal Jaafar, Lama Alabdi, Fowzan S. AlkurayaKing Faisal Specialist Hospital and Research Center. Lifera Omics.Saudi Arabia Clinical GeneticsClin Genet 2026; DOI: 10.1111/cge.70191 AbstractGrowth differentiation factor

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Pulmonary Endarterectomy in Pediatric Patients: Institutional Experience

Çağatay Çetinkaya, Nezih Onur Ermerak, Ela Erdem, Figen Akalın, Koray Ak, Eylem Tuncer, Altuğ Sağır, Bedrettin Yildizeli BedrettinUskudar University. Marmara University. University of Health Sciences.Turkey Thoracic and Cardiovascular SurgeonThorac Cardiovasc Surg 2026; DOI: 10.1055/a-2875-1852 AbstractBackground: Chronic thromboembolic pulmonary hypertension (CTEPH) is rare in children and published experience with pulmonary endarterectomy (PEA) is limited.Methods: We retrospectively reviewed six patients

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Pediatric Pulmonary Infarction and Infarction-Like Pulmonary Injury: An Etiology-Oriented Narrative Review

Shuxuan Li, Yanran Zhang, Xiangxiang Tian, Wanqing Zhao, Yongsheng XuTianjin Medical University and Tianjin Children’s Hospital (Children’s Hospital of Tianjin University).China Seminars in Thrombosis and HemostasisSemin Thromb Hemost 2026; DOI: 10.1055/a-2889-7005 Abstract Pulmonary infarction (PI) has traditionally been regarded as a complication of pulmonary embolism (PE). However, increasing evidence suggests that pediatric PI represents a heterogeneous

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Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension: A Single-Center Cohort to Inform Decision-Making

Taylor M. Smith, Kathryn Restaino, Stuart Lipsitz, Jai Krishan Khurana, Mary P. Mullin, John N. Kheir, Katie M. MoynihanBoston Children’s Hospital, Brigham and Women’s Hospital and Harvard Medical School. United States American Society of Artificial Internal Organs JournalASAIO J 2026; DOI: 10.1097/MAT.0000000000002766 AbstractLimited data describe children with pulmonary hypertension (PH) supported on extracorporeal membrane oxygenation (ECMO).

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Perioperative anesthetic management in pediatric patients with medically refractory pulmonary arterial hypertension undergoing surgical or transcatheter potts shunt: a retrospective case series

Liping Sun, Ning Ma, Xiafeng Yu, Lijun Fu, Yanjun Sun, Hao Zhang, Jijian Zheng, Jie BaiShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine.China Biomedical Central AnesthesiologyBMC Anesthesiol 2026; DOI: 10.1186/s12871-026-03998-3 AbstractBackground: Pulmonary arterial hypertension (PAH), a life-threatening disorder in children, necessitates palliative interventions like Potts shunt (surgical/transcatheter) for medically

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Phenotyping bronchopulmonary dysplasia using magnetic resonance imaging

Samal Munidasa, Paul S. Kingma, Jason C. Woods, James A. RoweCincinnati Children’s Hospital and University of Cincinnati College of Medicine.United States Paediatric Respiratory ReviewsPaediatr Respir Rev 2026; DOI: 10.1016/j.prrv.2026.06.003 AbstractBronchopulmonary dysplasia (BPD) is characterized by impaired lung development and persistent respiratory morbidity. BPD comprises three primary phenotypes: parenchymal, airway, and pulmonary vascular disease. Parenchymal disease involves

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Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning

Cristina Almagro-Pérez, Niccolò Peruzzi, Csaba Galambos, Andrew H.Song, Hans Brunnström, KingaI. Gawlik, MarcoStampanoni, Karin Tran-Lundmark, Goran LovricPaul Scherrer Institut. Institute for Biomedical Engineering. Lund University and Skåne University Hospital Lund. University of Colorado Anschutz Medical Campus School of Medicine. University of Texas MD Anderson Cancer Center. Switzerland, Sweden and United States Journal of the Royal

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KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension

Rehab Alharbi, Merve Keles, Nadia Fernandes, Hannah Maude, Adam Fellows, Richard D. Williams, Chien-Nien Chen, Nathalie Lambie, Nik Matthews, May Al-Sahaf, Sam N. Barnett, Minzhe Guo, Lan Zhao, Allan Lawrie, Jeffrey A. Whitsett, Inês Cebola, Beata Wojciak-StothardImperial College London. University of Hafr Al Batin. Hammersmith Hospital. Cincinnati Children’s Hospital Medical Center and University of Cincinnati

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Clinical phenotypes and mortality predictors in pediatric critical pertussis: A multinational study

Mohammad Alghounaim, Naila A. Shaheen, Abdulrahman Aldaithan, Saif Awlad Thani, Yasser Kazzaz, Abdulla Alfraij, On behalf of the Gulf Pediatric Pertussis Study (GPPS) Group Amiri Hospital, Ministry of Health. King Abdullah International Medical Research Center. King Saud bin Abdulaziz University for Health Sciences. Farwaniya Hospital. Royal Hospital.Kuwait, Saudi Arabia and Oman Journal of Infection and

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