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High Altitude May Protect Against the Early Development of Irreversible Pulmonary Hypertension in Patients With Congenital Heart Disease

Inge von Alvensleben, Brian B. Graham, Gustavo A. Balanza, Carlos Brockmann, Ericka C. Pérez, Ximena Y. Vicente, Carla Arteaga, Claudia Scherer, Franz P. Freudenthal, Rubin M. Tuder, Alexandra HeathKardiozentrum. University of Colorado. University of California San Francisco. Massachusetts General Hospital and Harvard Medical School. Hospital Belga.Bolivia and United States Pulmonary CirculationPulm Circ 2025; 15:  DOI: 10.1002/pul2.70049 […]

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Iatrogenic esophageal dysmotility as a barrier to transplantation in pulmonary arterial hypertension

Michael S. Miller, Shelsey W. Johnson, Alexander R. Opotowsky, Michael J. Landzberg, Nirmal S. Sharma, Hilary J. Goldberg, Alexandra K. Wong, Alison S. Witkin, Josanna Rodriguez-Lopez, Ronald H. Goldstein, Bradley A. Maron, Bradley M. WertheimBrigham and Women’s Hospital, Boston Children’s Hospital and Harvard Medical School. Veterans Affairs Boston Healthcare System. University of Cincinnati School of

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Homeostatic Role of Decorin in Right Ventricular Pressure Overload and Pulmonary Hypertension Induced Remodeling

Yohei Akazawa, Sriram Vaidyanathan, Michael Bradley Dewar, Kana Yazaki, John Dauz, Osami Honjo, Mei Sun, Golam Kabir, Robert P. Jankov, Scott Patrick Heximer, Kim A. Connelly, Mark K. FriedbergHospital for Sick Children and University of Toronto. Stanford University. St. Michael’s Hospital. Children’s Hospital of Eastern Ontario Research Institute.Canada and United States Journal of the American

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Serial echocardiography in preterm infants with bronchopulmonary dysplasia: diagnosing and managing recurrent pulmonary vein stenosis

Oishi Sikdar, Mahesh Nanjundappa, Aaron Bell, Matthew Jones and Anne GreenoughKing’s College London. Evelina Children’s Hospital. United Kingdom Case Reports in Perinatal MedicineCase Rep Perinat Med 2025; 14: DOI: 10.1515/crpm-2024-0038 AbstractObjectives: To highlight the importance of serial echocardiography in preterm infants with bronchopulmonary dysplasia (BPD) to diagnose recurrent pulmonary vein stenosis (PVS) and understand its contribution to

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Pathogenic SMAD6 variants in patients with idiopathic and complex congenital heart disease associated pulmonary arterial hypertension

Sofia Karl, Ekkehard Grünig, Memoona Shaukat, Matthias Held, Christian Apitz, Fabian von Scheidt, Ralf Geiger, Michael Halank, Karen M. Olsson, Marius M. Hoeper, Jan C. Kamp, Gabor Kovacs, Horst Olschewski, Hans-Jürgen Seyfarth, Katrin Milger, Ralf Ewert, Hans Klose, Benjamin Egenlauf, Panagiota Xanthouli, Katrin Hinderhofer, Christina A. EichstaedtHeidelberg University Hospital and Heidelberg University. KWM Missio Clinic.

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Intraamniotic Vitamin D Preserves Lung Development and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia due to Intraamniotic sFlt-1

Michael W. Cookson, Tania Gonzalez, Elisa M. Bye, Greg Seedorf, Sarah Ellor, Brad J. Smith, James C. Fleet, Erica W. MandellUniversity of Colorado, Anschutz School of Medicine and Children’s Hospital Colorado. University of Texas.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00409.2024 AbstractPreterm infants born

Intraamniotic Vitamin D Preserves Lung Development and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia due to Intraamniotic sFlt-1 Read More »

Follow-up of transcatheter closure of congenital heart disease complicated with pulmonary arterial hypertension in children

Yanyun Huang, Yuting Chen, Danyan Su, Suyuan Qin, Cheng Chen, Dongli Liu, Bingbing Ye, Yuqin Huang, Piaoliu Yuan, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University. China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1562782 AbstractBackground: Transcatheter closure is now the preferred treatment for congenital heart disease complicated with pulmonary arterial hypertension (CHD-PAH), but its long-term effects

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Increased circulating Endothelin-1 is a risk factor for ECMO use and mortality in neonates with congenital diaphragmatic hernia: a prospective observational study

Lotte Lemloh, Aster de Vadder, Tamene Melaku, Bartolomeo Bo, Neil Patel, Stefan Holdenrieder, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn. Royal Hospital for Children. Technical University of Munich. University Medical Center Mannheim, University of Heidelberg.Germany and United Kingdom Respiratory ResearchRespir Res 2025; 25: DOI: 10.1186/s12931-025-03188-8 AbstractBackground: Elevated levels of Endothelin-1 (ET-1), a vasoactive peptide, have been

Increased circulating Endothelin-1 is a risk factor for ECMO use and mortality in neonates with congenital diaphragmatic hernia: a prospective observational study Read More »

Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation

Benjamin S. Frank, Sierra Niemiec, Ludmila Khailova, Christopher A. Mancuso, Max B. Mitchell, Gareth J. Morgan, Mark Twite, Michael V. DiMaria, Carmen C. Sucharov, Jesse A. DavidsonUniversity of Colorado. University of Michigan.United States Journal of the American College of Cardiology AdvancesJACC Adv 2025; 4: DOI: 10.1016/j.jacadv.2025.101672 AbstractBackground: Endothelin-1 (ET1) is a potent vasoconstrictor and stimulator of pulmonary

Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation Read More »

Images: Atypical resolution of sleep-related hypoventilation in congenital central hypoventilation syndrome

Michelle Yoo, Amit Shah, Haitham Shahrour, Hong Li, Ajay S. KasiEmory University and Children’s Healthcare of Atlanta.United States Journal of Clinical Sleep MedicineJ Clin Sleep Med 2025;DOI: 10.5664/jcsm.11644 AbstractPaired-like homeobox 2B (PHOX2B) gene variants cause congenital central hypoventilation syndrome (CCHS) characterized by abnormal ventilatory control necessitating lifelong assisted ventilation (AV). We report a 3-year-old girl who

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