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Pulmonary-to-Systemic Arterial Shunt to treat Children with Severe Pulmonary Hypertension

R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, MD, Scott E. Fletcher, Russel Hirsch, Tilman Humpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien BonnetWashington University, A.N. Bakoulev […]

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Prematurity and Pulmonary Vein Stenosis: The Role of Parenchymal Lung Disease and Pulmonary Vascular Disease

Shilpa Vyas-Read, Nidhy P. Varghese, Divya Suthar, Carl Backes, Satyan Lakshminrusimha, Christopher J. Petit, Philip T. LevyEmory University and Children’s Healthcare of Atlanta. Baylor College of Medicine and Texas Children’s Hospital. Ohio State University and Nationwide Children’s Hospital. University of California Davis. Harvard University and Boston Children’s Hospital.United States Children (Basel)Children 2022; 9: DOI: 10.3390/children9050713 AbstractPulmonary

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Systemic Sirolimus Therapy for Infants and Children With Pulmonary Vein Stenosis

Jay D. Patel, Michael Briones, Mansi Mandhani, Shannon Jones, Divya Suthar, Rosemary Gray, Joelle Pettus, Courtney McCraken, Amanda Thomas, Christopher J. PetitEmory University and Children’s Healthcare of AtlantaUnited States Journal of the American College of CardiologyJ Am Coll Cardiol 2021; 77: 2807-2818DOI: 10.1016/j.jacc.2021.04.013 AbstractBackground: Anatomic interventions for pulmonary vein stenosis (PVS) in infants and children have been

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The vascular phenotype of BPD: new basic science insights-new precision medicine approaches

Wojciech Durlak, Bernard ThébaudUniversity of Ottawa. Jagiellonian University Medical College. Poland and Canada Pediatric ResearchPediatr Res 2022; DOI: 10.1038/s41390-022-02428-7 AbstractBronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Up to 1/3 of children with BPD develop pulmonary hypertension (PH). PH increases mortality, the risk of adverse neurodevelopmental outcome and lacks effective treatment. Current vasodilator

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Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target

Stephen L. Archer, Glenn Marsboom, Gene H. Kim, Hannah J. Zang, Peter T. Toth, Eric C. Svensson, Jason R. B. Dyke, Mardi Gomberg-Maitland, Bernard Thébaud, Aliya N. Husain, Nicole Cipriani, Jalees RehmaneUniversity of Chicago. University of Alberta.United States and Canada CirculationCirculation 2010; 121: 2661-2671DOI: 10.1161/CIRCULATIONAHA.109.916098 AbstractBackground: Excessive proliferation and impaired apoptosis of pulmonary artery (PA) smooth muscle

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Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension

Lingli Wang, Jan Renier Moonen, Aigin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pi-I. Chen, Mingxia Xu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, YuMee Kim, Kryn Stankunas, Marlene RabinovitchStanford University School of Medicine, Howard Hughes Medical Institute, and Lucille Packard Children’s HospitalUnited States Circulation ResearchCirc Res 2023;

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Primary pulmonary vein stenosis during infancy: state of the art review

David B. Frank, Philip T. Levy, Corey A. Stiver, Brian A. Boe, Christopher W. Baird, Ryan M. Callahan, Charles V. Smith, Rachel D. Vanderlaan, Carl H. BackesUniversity of Pennsylvania and Children’s Hospital of Philadelphia. Harvard University and Boston Children’s Hospital. Ohio State University and Nationwide Children’s Hospital. University of Washington and Seattle Children’s Research Institute.

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Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation

Emmanouil Mavrogiannis, Quint A. J. Hagdorn, Venetia Bazioti, Johannes M. Douwes, Diederik E. Van Der Feen, Silke U. Oberdorf‐Maass, Marit Westerterp, Rolf M. F. BergerBeatrix Children’s Hospital, University Medical Center Groningen and University of GroningenNetherlands Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12101 AbstractPulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure,

Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation Read More »

Pulmonary hypertension in extremely preterm infants: a call to standardize echocardiographic screening and follow-up policy

Sanne Arjaans, Elvira A. H. Zwart, Marc Roofthooft, Elisabeth M. W. Kooi, Arend F. Bos, Rolf M. F. BergerBeatrix Children’s Hospital, University Medical Center Groningen and University of GroningenNetherlands European Journal of PediatricsEur J Pediatr 2021; 180: 1855-1865DOI: 10.1007/s00431-021-03931-5 AbstractPulmonary hypertension (PH) is a frequent complication in extremely preterm born infants that seriously affects outcome. We

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Risk stratification in adult and pediatric pulmonary arterial hypertension: A systematic review

Chantal Lokhorst, Sjoukje van der Werf, Rolf M. F. Berger, Johannes M. DouwesUniversity of Groningen, Beatrix Children’s Hospital and University Medical Center GroningenNetherlands Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; 9: 1035453DOI: 10.3389/fcvm.2022.1035453 AbstractIntroduction: Currently, risk stratification is the cornerstone of determining treatment strategy for patients with pulmonary arterial hypertension (PAH). Since the 2015 European Society of

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