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Sotatercept for the Treatment of Pulmonary Arterial Hypertension

Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Jennifer Barnes, Peter G. Linde, Janethe de Oliveira Pena, David B. BadeschPULSAR Trial Investigators.France, United States, United Kingdom, […]

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Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension

Marc Humbert, Vallerie McLaughlin, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Marius M. Hoeper, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Hossein-Ardeschir Ghofrani, Pilar Escribano Subias1, Jeremy Feldman, Gisela Meyer, David Montani, Karen M. Olsson, Solaiappan Manimaran, Janethe de Oliveira Pena, David B. BadeschHôpital Bicêtre, Assistance Publique-Hôpitaux de Paris. University of Michigan Health System. Imperial

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Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension

Paul J. Critser, Nara S. Higano, Jean A. Tkach, Emilia S. Olson, David R. Spielberg, Paul S. Kingma, Robert J, Fleck, Sean M. Lang, Ryan A. Moore, Michael D. Taylor, Jason C. WoodsUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center. Baylor College of Medicine and Texas Children’s Hospital.United States American Journal of Respiratory and

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Recovery of right ventricular function after bilateral lung transplantation for pediatric pulmonary hypertension

Paul J. Critser, Debra Boyer, Gary A. Visner, Shane L. Collins, Mary P. MullenHarvard University and Boston Children’s Hospital.United States Pediatric TransplantationPediatr Transplant 2022; 26: e14236DOI: 10.1111/petr.14236 AbstractBackground: Lung transplantation is a therapeutic option for end-stage pediatric pulmonary hypertension (PH). Right ventricular (RV) recovery post-lung transplant in children with PH has not been well-described, and questions persist

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Echocardiography-derived septal curvature correlated with invasive hemodynamics in pediatric pulmonary hypertension

Paul J. Critser, Patrick D. Evers, Kristin Schneider, Russel Hirsch, Michael D. Taylor, Jason C. Woods, Sean M. LangUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center.United States Journal of EchocardiographyJ Echocardiogr 2022; 20: 24-32DOI: 10.1007/s12574-021-00545-6 AbstractBackground: Right ventricular function and afterload are associated with clinical outcomes in pulmonary hypertension (PH). MRI-derived interventricular septal curvature has been

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Prognostic value of longitudinal vasoreactivity in pediatric pulmonary hypertension

Patrick D. Evers, Patrick Quinn, Paul J. Critser, Benjamin S. Frank, Laurie B. ArmsbyOregon Health Sciences University. University of Cininnati. University of Colorado.United States Pulmonary CirculationPulm Circ 2022; 12: e12152DOI: 10.1002/pul2.12152 AbstractUpon diagnosis of pulmonary hypertension in pediatrics, standard practice often involves acute vasoreactivity testing (AVT) in the cardiac catheterization laboratory. However, the importance of repeated

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Pulmonary Vascular Sequelae of Palliated Single Ventricle Circulation: Arteriovenous Malformations and Aortopulmonary Collaterals

Andrew D. Spearman, Salil GindeMedical College of WisconsinUnited States Journal of Cardiovascular Development and DiseaseJ Cardiovasc Dev Dis 2023; 9: 309DOI: 10.3390/jcdd9090309 AbstractChildren and adults with single ventricle congenital heart disease (CHD) develop many sequelae during staged surgical palliation. Universal pulmonary vascular sequelae in this patient population include two inter-related but distinct complications: pulmonary arteriovenous malformations

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Reintervention and mortality risk after total anomalous pulmonary venous connection repair

Kevin M. Beers, Christian P. Jacobson, Stewart R. Miller, David G. Lehenbauer, Elaine Maldonado, S. Adil Husain, John H. CalhoonUniversity of Texas Health San Antonio.United States Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951122004280 AbstractBackground: Management of total anomalous pulmonary venous connections has been extensively studied to further improve outcomes. Our institution previously reported factors associated with

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Management of Complex Pulmonary Vein Stenosis at Altitude Combining Comprehensive Percutaneous Interventional Treatment with Sirolimus, Pulmonary Hypertension Medications and Intraluminal Imaging with Optical Coherence Tomography

Michael J. Shorofsky, Gareth J. Morgan, Ernesto Mejia, Salvador A. Rodriguez, Megan Greene, Paige Sheaks, Dunbar Ivy, Jenny E. ZablahUniversity of Colorado and Children’s Hospital Colorado.United States Pediatric CardiologyPediatr Cardiol 2023; DOI: 10.1007/s00246-023-03102-3 AbstractBackground: Pulmonary vein stenosis (PVS) is a growing problem for the pediatric congenital heart population. Sirolimus has previously been shown to improve survival and

Management of Complex Pulmonary Vein Stenosis at Altitude Combining Comprehensive Percutaneous Interventional Treatment with Sirolimus, Pulmonary Hypertension Medications and Intraluminal Imaging with Optical Coherence Tomography Read More »

Novel use of riociguat in infants with severe pulmonary arterial hypertension unable to wean from inhaled nitric oxide

Liezl T. Domingo, D. Dunbar Ivy, Steven H. Abman, Alicia M. Grenolds, James T. MacLean, J. A. Breaux, Katie J. Minford, Benjamin S. FrankUniversity of Utah. University of Colorado.United States Frontiers in PediatricsFront Pediatr 2022; 10: DOI: 10.3389/fped.2022.1014922 AbstractIntroduction: Riociguat, an oral soluble guanylate cyclase stimulator, has been approved for use in adults with pulmonary arterial hypertension

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