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The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins

G. G. Edel, M. van Kempen, A. Boerema‑de Munck, C. N. Huisman, C. A. P. Naalden, R. W. W. Brouwer, S. Koornneef, W. F. J. van IJcken, R. M. H. Wijnen, R. J. RottierErasmus MC-Sophia. Netherlands Journal of Biomedical ScienceJ Biomed Sci 2024; 31: DOI: 10.1186/s12929-024-01088-5 AbstractBackground: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is […]

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A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation

Jason Williams, Franklyn N. Iheagwam, Sean P. Maroney, Lauren R. Schmitt, R. Dale Brown, Greta M. Krafsur, Maria G. Frid, Maxwell C. McCabe, Aneta Gandjeva, Kurt J. Williams, James P. Luyendyk, . Anthony J. Saviola, Rubin M. Tuder, Kurt Stenmark, Kirk C. HansenUniversity of Colorado Denver and University of Colorado Anschutz Medical Campus. Michigan State

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Mitral Valve Intervention, Pulmonary Hypertension, and Survival in 219 Shone’s Syndrome Patients

Dominique L. Tucker, Sohini Gupta, Amol Pande, Rashed Mahboubi, Miza Salim Hammoud, Munir Ahmad, Hani Najm, Tara Karamlou, Shone’s Syndrome Working GroupCleveland Clinic, Cleveland and Case Western Reserve University School of Medicine. United States Annals of Thoracic SurgeryAnn Thorac Surg 2024; DOI: 10.1016/j.athoracsur.2023.10.023 AbstractBackground: Relationships between pulmonary hypertension (PHTN), mitral valve intervention (MVI), and death among patients

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Principles of resuscitation for infants with severe bronchopulmonary dysplasia

Summer Elshenawy, Monique R. Radman-Harrison, Philip T. Levy, Satyan Lakshminrushimha, Taylor L. Sawyer, Brenda H. LawChildren’s Healthcare of Atlanta and Emory University School of Medicine. Seattle Children’s Hospital and University of Washington School of Medicine. Boston Children’s Hospital and Harvard Medical School. UC Davis Children’s Hospital, UC Davis Health. University of Alberta Faculty of Medicine

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Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension

Haihao Sun, Norman Stockbridge, D. Dunbar Ivy, Jennifer Clark, Angela Bates, Stephanie S. Handler, Usha S. Krishnan, MAry P. Mullen, Delphine Yung, Rachel K. Hopper, Nidhy P. Varghese, Catherine M. Avitabile, Jeff Fineman, Eric D. Austin, Grace FreireU.S. Food and Drug Administration. University of Colorado School of Medicine. Stollery Children’s Hospital and University of Alberta.

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Accidental finding of ALCAPA in a child with severe mitral regurgitation: A case study

Budi Rahmat, Radityo Prakoso, Rafles Ph Simbolon, Albert T. Lopolisa, Muhammad Rayhan, Eva M. MarwaliNational Cardiovascular Center Harapan Kita and Universitas Indonesia. Indonesia Asian Cardiovascular Thoracic AnnalsAsian Cardiovasc Thorac Ann 2024; DOI: 10.1177/02184923241295550 AbstractCase report: A six-year-old child who had undergone cardiac surgery five years ago presented to us with severe mitral valve regurgitation. During her current

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Oral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial

Aditya Kallimath, Sujata Deshpande, Pari Singh, Reema Garegrat, Satyan Lakshminrusimha, Rajesh Maheshwari, Pradeep SuryawanshiBharati Vidyapeeth (Deemed to be University) Medical College. Imperial College. University of California Davis Children’s Hospital. Westmead Hospital.India, United Kingdom, United States and Australia BioMedical Central PediatricsBMC Pediatr 2024; 24: DOI: 10.1186/s12887-024-05107-0 AbstractBackground: Access to inhaled nitric oxide (iNO) is limited in low resource

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Oxygen saturation targets in neonatal care: A narrative review

Tri C. Nguyen, Rajeshwari Madappa, Heather M. Siefkes, Michelle J. Lim, Kanya Mysore Siddegowda, Satyan LakshminrusimhaKaiser Permanente North California. SIGMA Hospital. University of California Davis Children’s Hospital.United States Early Human DevelopmentEarly Hum Dev 2024; 199:DOI: 10.1016/j.earlhumdev.2024.106134 AbstractOptimal oxygenation requires the delivery of oxygen to meet tissue metabolic demands while minimizing hypoxic pulmonary vasoconstriction and oxygen toxicity.

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Global research landscape on the genetics of congenital heart disease: A bibliometric and visualized analysis via VOSviewer and CiteSpace

Fan Zhang, Lei Qi, Mingxue Zhao, Shuming Han, Haoran Zhang, Guangxin WangJinan Central Hospital, Shandong University. China MedicineMedicine 2024; 103: DOI: 10.1097/MD.0000000000040261 AbstractGenetic factors play a significant role in the development of congenital heart disease (CHD). Many studies on the genetics of CHD have been published worldwide; however, no research has assessed and mapped the global

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Integrated multi-omics analysis of the microbial profile characteristics associated with pulmonary arterial hypertension in congenital heart disease

Jiahui Xie, Xiaoyu Zhang, Liming Cheng, Yao Deng, Haobo Ren, Minghua Mu, Liang Zhao, Chunjie Mu, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University. First hospital of Kunming. Kunming Children’s Hospital.China Microbiology SpectrumMicrobiol Spectr 2024; DOI: 10.1128/spectrum.01808-24 AbstractDysregulation of immune and inflammatory cells around blood vessels and metabolic dysfunction are key mechanisms in the development of pulmonary arterial hypertension (PAH). The homeostasis of the human microbiome

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