Medical Therapy. Efficacy or Lack of Efficacy Archives - Page 8 of 27

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

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Cough-induced chylothorax in a two-year-old boy – case report and review of the literature

Melanie Anger, Julian Hofmann, Bettina Ruf, Marc Steinborn, Daniela Reber, Katharina Warncke, Nikolaus RieberKinderklinik München Schwabing, Munich Klinik and School of Medicine and Technical University of Munich. Germany BioMed Central PediatricsBMC Pediatr 2023; 23:DOI: 10.1186/s12887-023-04221-9 AbstractBackground: Chylothorax is a very rare form of pleural effusion in children, especially after the neonatal period, and predominantly occurs secondary to cardiothoracic

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Pleurodesis using OK-432 for persistent pleural effusion after cardiac surgery in the neonatal period or early infancy

Tomohiro Nakata, Maiko Tachi, Kenji Yasuda, Shigeki Nakashima, Tadashi Ikeda, Kenji Minatoya, Teiji OdaShimane University Faculty of Medicine. Kyoto University Faculty of Medicine.Japan Asian Cardiovascular and Thoracic AnnalsAsian Cardiovasc Thorac Ann 2024; 32: 83-90DOI: 10.1177/02184923231219606 AbstractObjective: To evaluate the efficacy of pleurodesis using OK-432 after cardiac surgery in the neonatal period or early infancy.Methods: We retrospectively reviewed the

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Current practices for refractory chylothorax following congenital heart surgery

Gregory T. Adamson, Melissa M. Winder, Kirsti G. Catton, Aaron G. Dewitt, Benjamin W. Kozyak, Emilee T. Glenn, David K. BaillyStanford University School of Medicine. University of Utah. Perelman School of Medicine at the University of Pennsylvania.United States Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123003918 AbstractIntroduction: Chylothorax following paediatric cardiac surgery is associated with significant morbidity,

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Chylothorax related to acute SARS-CoV-2 infection in a patient with Noonan syndrome with prior uncomplicated cardiac surgeries

Lubaina Ehsan, Jessica A. Thoe, John J. Parent, Joseph D. FakhouryWestern Michigan University Homer Stryker M.D, School of Medicine and Bronson Children’s Hospital. Indiana University School of Medicine.United States Cardiology in the YoungCardiol Young 2024; 34: 448-451DOI: 10.1017/S1047951123004171 AbstractSARS-CoV-2 is a novel coronavirus that has rarely been associated with chylothorax. Patients with Noonan syndrome are at

The Road to Heart Transplant in a Patient With Cardiomyopathy, Shone Complex, and Severe Pulmonary Hypertension

Arif Albulushi, Shabib Al-Asmi, Moosa Al-Abri, Hatem Al-FarhanUniversity of Nebraska Medical Center. Royal Hospital. Heart Hospital, Armed Forces Hospital and Sultan Qaboos University Hospital. Hamad Medical Corporation. United States, Oman and Qatar Journal of the American College of Cardiology Case ReportsJACC Case Rep 2024; 29:DOI: 10.1016/j.jaccas.2024.102323 AbstractOur case report details the journey of a 16-year-old male

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Systemic juvenile idiopathic arthritis-associated lung disease: A retrospective cohort study

Konstantin E. Belozerov, Natalia M. Solomatina, Eugenia A. Isupova, Alla A. Kuznetsiva, Mikhail M. KostikSaint-Petersburg State Pediatric Medical University. Children’s City Polyclinic No. 29 of the Kalininsky District of St. Petersburg. Almazov National Medical Research Centre.Russia World Journal of Clinical PediatricsWorld J Clin Pediar 2024; 13:DOI: 10.5409/wjcp.v13.i1.88912 AbstractBackground: Lung damage in systemic juvenile arthritis (sJIA) is one

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Tadalafil in Neonates and Infants With Pulmonary Hypertension Secondary to Bronchopulmonary Dysplasia

Amy Kiskaddon, Tanaka Dang, Daniel MaurielloJohns Hopkins All Children’s Hospital. Johns Hopkins University School of Medicine. Texas Children’s Hospital.United States Journal of Pediatric Pharmacology and TherapeuticsJ Pediatr Pharmacol Ther 2024; 29: 140-143DOI: 10.5863/1551-6776-29.2.140 AbstractObjectives: The primary outcome of this study was to describe the dosing regimen of tadalafil in neonates and infants diagnosed with pulmonary hypertension (PH)

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Low global arginine bioavailability: a common phenomenon in pulmonary hypertension

Dunia Hatabah, Teresa De Marco, Dana P. McGlothlin, Mary Malloy, Loretta Z. Reyes, Rawan Korman, Gregory J. Kato, Claudia R. MorrisEmory University School of Medicine. University of California, San Francisco. Kaiser Permanente San Francisco. Children’s Healthcare of Atlanta. Blood Science Consulting.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell

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