Medical Therapy. Efficacy or Lack of Efficacy

Case Report: Diffuse pulmonary lymphangiomatosis in a child

Ya-nan Zhang, Zhen Yuan, Jin-chen Du, Bin Liu, Fu Li, Shou-Cai Hu, Qing-Xin Li940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army. Gansu University of Traditional Chinese Medicine.China Frontiers in PediatricsFront Pediatr 2026; 13: DOI: 10.3389/fped.2025.1591611 AbstractWe report a rare case of generalized lymphatic anomaly (GLA) in a 12-year-old male, presenting with intermittent

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Does inhaled nitric oxide treatment of pulmonary hypertension in extremely premature infants improve patient outcomes?

Tyler L. King, Patrick J. McNamara, Adrianne R. BischoffUniversity of Iowa.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02666-1 AbstractAbstract Not Available CategoryClass III. Pulmonary Hypertension Associated with Lung DiseaseMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Disease Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication Article Access

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Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension

Sarah M. Nofal, Abdel‑Rahman M. El‑Mashad, Asmaa M. Elmesiry, Amany M. Abouelenain, Mostafa M. AwnyTanta University.Egypt European Journal of PediatricsEur J Pediatr 2026; 185: DOI: 10.1007/s00431-026-06864-z AbstractThe aim of this study is to investigate the effects of melatonin on the left ventricular (LV) function in persistent pulmonary hypertension of the newborn (PPHN) and to assess its

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Lifesaving Compassionate-Use of Sotatercept in a 12-Year-old With Idiopathic Pulmonary Arterial Hypertension

Weronika Pelczar‐Płachta, Rafał Surmacz, Waldemar BobkowskiPoznan University of Medical Sciences.Poland Pulmonary CirculationPulm Circ 2026; 16DOI: 10.1002/pul2.70293 AbstractPediatric idiopathic pulmonary arterial hypertension (IPAH) refractory to maximal medical therapy is associated with high morbidity and mortality, and therapeutic options remain limited. We describe a 12-year-old girl with end-stage IPAH who developed acute decompensated right heart failure despite triple

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Sildenafil for bronchopulmonary dysplasia-associated pulmonary hypertension: A systematic search and narrative synthesis

Yoshinori Katayama, Katsuya Hirata, Yutaka Nishimura, Atsuko, Nakahari, Mami Takeoka, Masahiko Watanabe, Tetsuya Isayama, Japan Evidence Based NeonatologyTakatsuki General Hospital. Osaka Women’s and Children’s Hospital. Hiroshima City Hiroshima Citizens Hospital. Jichi Medical University Saitama Medical Center. Mie University Graduate School of Medicine. National Center for Child Health and Development.Japan Pediatrics InternationalPediatr Int 2026; 68: DOI: 10.1111/ped.70385

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Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts

Phoenix Plessas-Azurduy, Anie Lapointe, Punnanee Wutthigate, Sarah Spénard, Andréanne Villeneuve, Audrey Hébert, Eilon Shany, Justin Richardson, Neta Geva, Wadi Mawad, Tiscar Cavallé-Garrido, Marc Beltempo, Wissam Shalish, Guilherme Sant’Anna, Gabriel AltMcGill University. Université de Montréal, CHU Sainte-Justine. Mahidol University. Montreal Children’s Hospital. CHU de Québec and Laval University. Saban Children’s Hospital and Soroka Medical Center. Ben

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Parenteral treprostinil in paediatric pulmonary arterial hypertension: a systematic review and meta-analysis

Julie Wacker, Raphael Joye, Maurice BeghettiGeneva University Hospitals and Faculty of Medicine and University of Geneva.Switzerland European Respiratory ReviewEur Respir Rev 2026; DOI: 10.1183/16000617.0033-2025 AbstractBackground: Paediatric pulmonary arterial hypertension (PAH) shares commonalities with adult disease but is essentially different regarding complexity and is usually more challenging to treat. Current treatment recommendations are based on expert opinion, small-scale

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Updates in the Treatment of Pediatric Pulmonary Arterial Hypertension

Danya Z. Jafri, James M. Beck, Samantha A. Kaplan, Allegra Keeler, Bryan Sanchez, Daniela Brady, William H. Frishman, Wilbert S. Aronow, Avi Levine, Erika Rosenzweig, Gregg M. LanierNew York Medical College School of Medicine. Westchester Medical Center.United States Cardiology in ReviewCardiol Rev 2026; DOI: 10.1097/CRD.0000000000001239 AbstractPediatric pulmonary arterial hypertension (PAH) is a relentless and potentially fatal

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Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature

Sixie Zheng, Hao Li, Siqi She, Yiting Xue, Debao Li, Jiapei Wang, Jing Wang, Yuqing Hu, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. Affiliated Women and Children’s Hospital of Ningbo University. China Frontiers in ImmunologyFront Immunol 2026; 17: DOI: 10.3389/fimmu.2026.1780303

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Pulmonary Hypertension Associated With Vitamin C Deficiency Is Rapidly Reversible

Tomás Woodgate, Jay Patel, Thomas Day, Brodie Knight, Adriani Spanaki, Alistair Calder, Shahin Moledina, Sadia QuyamGreat Ormond Street Hospital. Royal Hospital for Children. Evelina London Children’s Hospital,United Kingdom PediatricsPediatrics 2026; DOI: 10.1542/peds.2025-073645 AbstractWe report 4 children (aged 3-9 years) with severe pulmonary hypertension (PH) associated with vitamin C deficiency. All presented with either musculoskeletal symptoms or

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