Medical Therapy. Efficacy or Lack of Efficacy

Factors leading to supranormal cardiac index in pediatric pulmonary hypertension patients treated with parenteral prostanoid therapy

Kimberley G. Miles Paul J. Critser, Patrick D. Evers, Michelle Cash, Melissa Magness, Elizabeth Geers Meredith O’Neil, Zhiqian Gao, Nicholas J. Ollberding, Russel HirschCincinnati Children’s Hospital Medical Center and Cincinnati College of Medicine. Oregon Health and Sciences University. United States Pulmonary CirculationPulm Circ 2023;DOI: 10.1002/pul2.12264 AbstractParenteral prostanoid therapy (PPT) can result in supranormal cardiac index (SCI; […]

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Echocardiographic Assessment of Pulmonary Arterial Hypertension Following Inhaled Nitric Oxide in Infants with Severe Bronchopulmonary Dysplasia

Maria V. Fraga, Kevin C. Dysart, Jason Z. Stroller, Matthew Huber, Anysia Fedec, Laura Mercer-Rosa, Haresh KirpalaniThe Children’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine. Nemours Children’s Health and duPont Hospital for Children. McMaster University.United States and Canada NeonatologyNeonatology 2023; DOI: 10.1159/000531586 AbstractObjectives: Inhaled nitric oxide (iNO) is an effective pulmonary vasodilator. However,

Echocardiographic Assessment of Pulmonary Arterial Hypertension Following Inhaled Nitric Oxide in Infants with Severe Bronchopulmonary Dysplasia Read More »

Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction

Michael G. Katz, Yoav Hadas, Adam Vincek, Lina Freage‑Kahn, Nataly Shtraizent, Jeko M. Madjarov, Peter Pastuszko, Efrat Eliyahu Icahn School of Medicine at Mount Sinai. SeneX Therapeutics Inc. Atrium Health Sanger Heart and Vascular Institute. Wake Forest School of Medicine. United States Respiratory ResearchRespir Res 2023; 24DOI: 10.1186/s12931-023-02487-2 AbstractBackground: Up-regulation of ceramides in pulmonary hypertension (PH), contributing to

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Practices and Outcomes from a Prospective, Multicenter Registry for Preterm Newborns with Pulmonary Hypertension

Nicolle Fernandez Dyess, Claire Palmer, Roger F. Soll, Reese H. Clark, Steven H. Abman, John P. Kinsella and the Preterm Newborn Pulmonary Hypertension Registry Study Group with Multiple Collaborating InvestigatorsUniversity of Colorado School of Medicine. University of Vermont. Pediatrix Center for Research. Multiple Collaborating Institutions.United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2023.113614 AbstractObjective: To describe current

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Pulmonary Vasodilator Therapy in Pediatric Patients on Ventricular Assist Device Support: A Single-Center Experience and Proposal for Use

Jennifer E. Schramm, John C. Dykes, Rachel K. Hopper, Jeffrey A. Feinstein, David N. Rosenthal, Rebecca J. KamenyJohns Hopkins University School of Medicine. Stanford University School of Medicine.United States American Society for Artificial Internal Organs JournalASAIO J 2023; DOI: 10.1097/MAT.0000000000002023 AbstractPediatric precapillary pulmonary hypertension can develop in response to systemic atrial hypertension. Systemic atrial decompression following

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Cardiopulmonary physiological effects of diuretic therapy in preterm infants with chronic pulmonary hypertension

Faith Zhu, Daniel Ibarra Rios, Sebastien Joye, Michelle Baczynski, Danielle Rios, Regan E. Giesinger, Patrick J. McNamara, Amish JainMount Sinai Hospital and University of Toronto. Hospital Infantil de México Federico Gómez. Lausanne University Hospital. University of Iowa.Canada, Mexico, Switzerland and United States Journal of PerinatologyJ Perinatol 2023DOI: 10.1038/s41372-023-01742-0 AbstractObjective: Using targeted neonatal echocardiography (TNE) to examine cardiopulmonary

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Association between immediate oxygenation response and survival in preterm infants receiving rescue inhaled nitric oxide therapy for hypoxemia from pulmonary hypertension: A systematic review and meta-analysis

Michelle Baczynski, Bonny Jasani, Charmaine De Castro, Carlo Dani, Nimish V. Subhedar, Praveen Chandrasekharan, Satvan Lakshminrusimha, Patrick J. McNamara, Adrianne R. Bishchoff, Amish JainMount Sinai Hospital. Hospital for Sick Children. Careggi University Hospital of Florence and University of Florence. Liverpool Women’s Hospital. University at Buffalo. UC Davis Children’s Hospital. University of Iowa. Canada, Italy, United

Association between immediate oxygenation response and survival in preterm infants receiving rescue inhaled nitric oxide therapy for hypoxemia from pulmonary hypertension: A systematic review and meta-analysis Read More »

Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats

Shiho Yoshida, Alexander M. Kreger, George K. Gittes UPMC Children’s Hospital of Pittsburgh and University of Pittsburgh School of Medicine.United States Frontiers in Bioengineering and BiotechnologyFront Bioeng Biotechnol 2023; DOI: 10.3389/fbioe.2023.1195623 AbstractPulmonary hypertension associated with congenital diaphragmatic hernia (CDH) is a critical factor in determining prognosis. We propose that intra-amniotic sildenafil administration is an effective prenatal therapy for

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Spontaneous neonatal pulmonary arterial thrombosis – cases, mechanisms, and literature review

Ali Abdelhafiz, Alexis L. Benscoter, Sarosh P. BatlivalaCincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine.United States Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123002639 AbstractSpontaneous pulmonary artery thrombosis in neonates is rare and can be life-threatening. Clinical presentation may mimic pulmonary hypertension or CHD. Further, not all children present with identifiable risk

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Vasopressin versus epinephrine during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets

Megan O’Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M. SchmolzerRoyal Alexandra Hospital and University of Alberta.Canada Resuscitation PlusResus Plus 2023; 15DOI: 10.1016/j.resplu.2023.100427 AbstractBackground: Epinephrine is currently the only recommended cardio-resuscitative medication for use in neonatal cardiopulmonary resuscitation (CPR), as per the consensus of science and treatment recommendations. An alternative medication, vasopressin, might be beneficial in neonatal CPR due

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