Medical Therapy. Efficacy or Lack of Efficacy

Sodium nitrite prevents impaired postnatal alveolar development

Kathrine L. Daniel, Chantal Gaudet, Ali Hamraghani, Nadya Ben Fadel, Behzad Yeganeh, Robert P. JankovChildren’s Hospital of Eastern Ontario Research Institute. University of Ottawa.Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00324.2024 AbstractDeficient nitric oxide (NO) signaling plays a critical role in the pathogenesis of bronchopulmonary

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Long-term survival of shunt closure in atrial septal defects with pulmonary arterial hypertension

Wenjie Chen, Jingyuan Chen, Min Peng, Jun Luo, Haihua Qiu, Yusi Chen, Jiang LiSecond Xiangya Hospital of Central South University. China International Journal of CardiologyInt J Cardiol 2025; DOI: 10.1016/j.ijcard.2025.133094 AbstractObjective: This study aims to refine closure indications and assess long-term outcomes in pulmonary arterial hypertension associated with atrial septal defect (PAH-ASD).Methods: We enrolled 197 PAH-ASD patients classified

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Ultrasonographic diagnosis and follow-up of a special type of giant fetal hepatic hemangioma

Xiaoyan Weng, Juan Jiang, Gang WenWomen and Children’s Hospital Affiliated to Ningbo University. China Pediatric RadiologyPediatr Radiol 2025; DOI: 10.1007/s00247-025-06196-4 AbstractWe present a case of giant fetal hepatic hemangioma to illustrate the impact of ultrasound monitoring on treatment outcomes. Prenatal ultrasound revealed cardiac enlargement, leading to a cesarean section. The neonate had multiple vascular anomalies, including

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Severe Precapillary Pulmonary Hypertension and Right Ventricular Failure After Hematopoietic Stem Cell Transplantation: Successful Outcomes With Aggressive Upfront Triple Therapy

Stine Andersen, Jesper Vandborg Bjerre, Karin Baekgaard, Lars Idorn, Mads Jønsson AndersenAarhus University Hospital and Aarhus University. Copenhagen University Hospital.Denmark Pediatric Blood and CancerPediatr Blood Cancer 2025; DOI: 10.1002/pbc.31623 AbstractAbstract Not Available CategoryClass V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic and Other DisordersMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Diseasec

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Valsartan to Prevent Acquired Pulmonary Vein Stenosis in Pediatric Patients After Total Anomalous Pulmonary Venous Connection Surgery

Jin Shentu, Mingjie Zhang, Zhuoming Xu, Chen Wen, Hao Zhang, Zhongqun Zhu, Huiwen Chen, Guocheng ShiShanghai Children’s Medical Center and Shanghai Jiao Tong University. China Journal of the American Heart AssociationJ Am Heart Assoc 2025; 14: DOI: 10.1161/JAHA.124.036911 AbstractBackground: Recurrent pulmonary vein stenosis (PVS) following surgical repair of total anomalous pulmonary venous connection is associated with poor prognosis. Preclinical studies have shown that use of an angiotensin receptor blocker can attenuate intimal

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Inhaled Epoprostenol in Children With Pediatric Acute Respiratory Distress Syndrome: A Single-Center Retrospective Study

Eleanor J. Scalone, Alan G. Woodruff, Amit K. Saha, John M. Wright, Kristopher L. Dixon, Andora L. Bass, Michael J. Walsh, Michael C. McCroryWake Forest University School of Medicine. University of Pennsylvania Perelman School of Medicine.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71010 AbstractBackground: Inhaled epoprostenol (iEpo) may improve oxygenation in adults with hypoxic respiratory failure,

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Tailored CD4+ lymphocytes expressing human CHAT protein as a novel vasodilator in attenuating RV pressure in PAH animal model

Akash Gupta, Nahla Zaghloul, Senthil Kumar Thulasingam, Ian Richard Robbins, Geetanjali Gupta, Jad Bader, Joe Gn Garcia, Mohamed AhmedUniversity of Arizona. University of Florida. United States Translational ResearchTransl Res 2025; DOI: 10.1016/j.trsl.2025.02.001 AbstractChAT-expressing T cells represent ∼0.01% of total circulating T lymphocytes in adult wild-type mice. However, we previously reported that systemic infusion of ChAT+ve Jurkat

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Case Report: severe pulmonary hypertension in a child with micronutrient deficiency

Laure Pache-Wannaz, Cristiana Voicu, Laurence Boillat, Nicole SekarskiLausanne University Hospital and University of Lausanne.Switzerland Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1478889 AbstractWe describe the rare case of a previously healthy seven year-old boy, with an acute clinical onset of severe pulmonary hypertension. He recovered rapidly after vitamin supplementation. Patient history showed a highly selective food

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Bosentan as adjunctive therapy in neonates with congenital diaphragmatic hernia-associated pulmonary hypertension: a case series

Aster De Vadder, Lotte Lemloh, Bartolomeo Bo, Lennart Hale, Neil Patel, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn. Royal Hospital for Children. Germany and United Kingdom European Journal of PediatricsEur J Pediatr 2025; 184: DOI: 10.1007/s00431-025-06019-6 AbstractCongenital diaphragmatic hernia (CDH)-associated pulmonary hypertension (PH) is associated with high morbidity and mortality. Pulmonary vasodilative management is challenging

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Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling

Ying Liang, Wojciech Ornatowski, Qing Lu, Xutong Sun, Manivannan Yegambaram, Anlin Feng, Yishu Dong, Saurabh Aggarwal, Hoshang J. Unwalla, Jeffrey R. Fineman, Stephen M. Black, Ting WangFlorida International University. University of California, San Francisco.United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26031352 AbstractPulmonary arterial hypertension (PAH) is characterized by increased lung

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