Medical Therapy. Efficacy or Lack of Efficacy

Atypical presentation and management of a neonate with alveolar capillary dysplasia: A case report

Niki Dermitzaki, Nikitas Chatzigiannis, Maria Baltogianni, Maria E. Kamperi, Antonios Vlahos, Alexandros Makis, Konstantinos Douros, Vasileios GiaprosUniversity of Ioannina. Athens University Medical School and “Attikon” University Hospital.Greese Pediatric PulmonologyPediatr Pulmonol 2024; DOI: 10.1002/ppul.27241 AbstractAbstract Not Available CategoryClass III. Pulmonary Hypertension Associated with Developmental Diseases of the LungMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric […]

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A Single Center Experience of Pulmonary Arterial Hypertension Management in Korea: A 25-Year Comparative Analysis Following the Introduction of Targeted Therapy

Ji Hyun Cha I-Seok Kang, Shin Yi Jang, June Huh Jeong Hoon Yang, Jinyoung Song, Taek Kyu Park, Seung Woo Park, Hojoong Kim, Duk-Kyung Kim Sung-A ChangSamsung Medical Center, Samsung Changwon Hospital and Sungkyunkwan University School of Medicine. Republic of Korea Korean Circulation JournalKorean Circ J 2024; DOI: 10.4070/kcj.2023.0316 AbstractBackground and objectives: The transformation of pulmonary arterial

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Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

Ekaterina Legchenko, Philippe Chouvarine, Fatimunnisa Qadri, Edgar Specker, Marc Nazaré, Radoslaw Wesolowski, Susann Matthes, Michael Bader, Georg HansmannHannover Medical School. Max-Delbrück-Center for Molecular Medicine. Trypto Therapeutics GmbH. German Center for Cardiovascular Research. Charité Universitätsmedizin Berlin. University of Lübeck. Friedrich-Alexander-University Erlangen-Nürnberg. Germany Journal of the Amerian College of Cardiology Basic to Translational ScienceJACC Basi Transl Sci

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression Read More »

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension

Qiang Meng, Linhong Song, Hui Wang, Gang Wang, Gengxu ZhouSeventh Medical Center of the PLA General Hospital. Southern Medical University. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02945-5 AbstractBackground: Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension Read More »

Biological impact of manual blood exchange in malignant Bordetella pertussis infection in infants

Vladimir L. Cousin, Caroline Caula, Pierre TissieresAssistance Publique des Hôpitaux de Paris and Paris Saclay University and Bicêtre Hospital. Geneva University Hospital. Hôpital Robert-Debré. France and Switzerland Vox SanguinisVox Sang 2024; DOI: 10.1111/vox.13722 AbstractBackground and objectives: Manual blood exchange (MBE) is a leukoreduction therapy for hyperleukocytosis in Bordetella spp.Infection: We describe the impact of BE on clinical and

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Hybrid treat-and-repair strategy for large patent ductus arteriosus: a proof-of-concept case report

Naoki Tsuboya, Yoshihide Mitani, Hiroyuki Ohashi, Hirofumi Sawada, Masahiro HirayamaMie University Graduate School of Medicine.Japan European Heart Journal Case ReportsEur Heart J Case Rep 2024; DOI: 10.1093/ehjcr/ytae354 AbstractBackground: In cases of atrial septal defect with pulmonary arterial hypertension (PAH), a treat-and-repair strategy that adopts pulmonary vasodilator therapy and subsequent defect closure is postulated to be effective. However,

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Safety and Effectiveness of Selexipag in Pediatric Pulmonary Hypertension: A Retrospective Multi-Center Cohort Study

Benjamin S. Frank, Eliza R. Gentzler, Catherine M. Avitabile, Kathleen Miller-Reed, Zhaoxing Pan, Erika B. Rosenzweig, D. Dunbar Ivy, Usha S. KrishnanUniversity of Colorado School of Medicine and Children’s Hospital Colorado. Columbia University Irving Medical Center and Morgan Stanley Childrens Hospital of New York Presbyterian Hospital. University of Pennsylvania School of Medicine and Children’s Hospital

Safety and Effectiveness of Selexipag in Pediatric Pulmonary Hypertension: A Retrospective Multi-Center Cohort Study Read More »

Machine Learning Analysis of Predictors for Inhaled Nitric Oxide Therapy Administration Time Post Congenital Heart Disease Surgery: A Single-Center Observational Study

Shuhei Niiyama, Takahiro Nakashima, Kentaro Ueno, Daisuke Hirahara, Masatoyo Nakajo, Yutaro Madokoro, Mitsuhito Sato, Kenshin Shimono, Takahiro Futatsuki, Yasuyuki KakihanaKagoshima University Hospital and Graduate School of Medical and Dental Sciences of Kagoshima University. Harada Academy. Japan CureusCureus 2024; 16:DOI: 10.7759/cureus.65783 AbstractBackground: Congenital heart disease (CHD) is a structural deformity of the heart present at birth. Pulmonary

Machine Learning Analysis of Predictors for Inhaled Nitric Oxide Therapy Administration Time Post Congenital Heart Disease Surgery: A Single-Center Observational Study Read More »

Magnetic Resonance Imaging Assessment of Pulmonary Vascularity in Preterm Infants with Bronchopulmonary Dysplasia

Shanmukha Muthapuram, Addison Donaher, Nara S. Higano, James A. Rowe, Jean A. Tkach, Jason C. Woods, Paul S. KingmaCincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine. United States NeonatologyNeonatology 2024; DOI: 10.1159/000539545 AbstractIntroduction: Pulmonary hypertension often complicates bronchopulmonary dysplasia (BPD) and infants with BPD plus pulmonary hypertension experience higher mortality rates. Current methods

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Real-world effectiveness and safety of macitentan in patients with pulmonary artery hypertension: a multicenter, retrospective, observational study in China

Yu-Cheng Chen, Hai-Long Dai, Chun-Li Liu, Jiang Li, Qiu-Shang Ji, Yun-Shan Cao, Jing Xiao, Rong Jian, Jian-Min Zhuo, Xin-Chao Luo, Hong GuWest China Hospital of Sichuan University. Yan’an Affiliated Hospital of Kunming Medical University. First Affiliated Hospital of Guangzhou Medical University. Second Xiangya Hospital of Central South University. Qilu Hospital of Shandong University. Gansu Provincial

Real-world effectiveness and safety of macitentan in patients with pulmonary artery hypertension: a multicenter, retrospective, observational study in China Read More »

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