Medical Therapy. Efficacy or Lack of Efficacy

Comparing the efficacy and safety of low, medium, and high dosages of selexipag for treating pulmonary hypertension: A systematic review and meta-analysis

Shang Wang, Yi Yan, Jian Zhang, Ping Yuan, Ci-Jun Luo, Hong-Ling Qiu, Hui-Ting Li, Lan Wang, Tian-Lan Li, Rong Jianghanghai Pulmonary Hospital, School of Medicine, Tongji University. Shanghai Children’s Medical Center, National Children’s Medical Center, Shanghai Jiaotong University School of Medicine. The Second Affiliated Hospital of Chengdu Medical College. The Affiliated Hospital of Qingdao University.China […]

Comparing the efficacy and safety of low, medium, and high dosages of selexipag for treating pulmonary hypertension: A systematic review and meta-analysis Read More »

Safety and tolerability of continuous inhaled iloprost in critically ill pediatric pulmonary hypertension patients: A retrospective case series

Elizabeth Colglazier, Angelica J. Ng, Clair Parker, David Woolsey, Raymond Holmes, Allison Dsouza, Jasmine Becerra, Leah Stevens, Hythem Nawaytou, Roberta L. Keller, Jeffrey R. FinemanUniversity of California, San Francisco. Merck Sharp & Dohme LLC. Benioff Children’s Hospital. United States Pulmonary CirculationPulm Circ 2023; 13DOI: 10.1002/pul2.12289 AbstractInhaled iloprost (iILO) has shown efficacy in treating patients with hypoxic

Safety and tolerability of continuous inhaled iloprost in critically ill pediatric pulmonary hypertension patients: A retrospective case series Read More »

Real-world safety and effectiveness of inhaled nitric oxide therapy for pulmonary hypertension during the perioperative period of cardiac surgery: a post-marketing study of 2817 patients in Japan

Emi Matsugi, Shigeki Takashima, Shuhei Doteguchi, Tomomi Kobayashi, Motohiro OkayasuMallinckrodt Pharmaceuticals. Japan General Thoracic and Cardiovascular SurgeryGen Thorac Cardiovasc Surg 2023; DOI: 10.1007/s11748-023-01971-2 AbstractObjective: To evaluate the real-world safety and effectiveness of inhaled nitric oxide (INOflo® for Inhalation 800 ppm) for perioperative pulmonary hypertension associated with cardiac surgery in Japan.Methods: This was a prospective, non-interventional, all-case, post-marketing study of

Real-world safety and effectiveness of inhaled nitric oxide therapy for pulmonary hypertension during the perioperative period of cardiac surgery: a post-marketing study of 2817 patients in Japan Read More »

Current and emerging pharmacotherapies for the treatment of pulmonary arterial hypertension in infants

Matthew F. Pizzuto, Matthew M. Laughon, Wesley M. JacksonUniversity of North Carolina at Chapel Hill.United States Expert Opinion on PharmacotherapyExpert Opin Pharmacother 2023; DOI: 10.1080/14656566.2023.2257598 AbstractIntroduction: Pulmonary hypertension (PH) is a complex condition that encompasses an array of underlying disease processes and affects a diverse population of infants, including those with congenital heart disease, congenital diaphragmatic hernia,

Current and emerging pharmacotherapies for the treatment of pulmonary arterial hypertension in infants Read More »

Continuous Prostanoid Initiation in Severe Pulmonary Hypertension in the Pediatric Cardiac Intensive Care Unit

Richard U. Garcia, Asaad Beshish, Arene Butto, Usama Kanaan, Kevin MaherEmory University School of Medicine and Children’s Healthcare of Atlanta.United States Pediatric CardiologyPediatr Cardiol 2023; DOI: 10.1007/s00246-023-03282-y AbstractObjective: Limited data exists regarding prostanoid (PGI2) use in critically ill patients with pulmonary hypertension. (PH) in the pediatric cardiac intensive care unit (CICU) setting.Materials and methods: Single center, retrospective study

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Intrastent sonotherapy in pulmonary vein restenosis: a new treatment for a recalcitrant problem

C. J. McMahon, C. E. Mullins, H. G. El SaidTexas Children’s Hospital, Baylor College of MedicineUnited States HeartHeart 2003; 89: E6DOI: 10.1136/heart.89.2.e6 AbstractA 2 year old boy developed recurrent pulmonary vein stenosis after surgical repair of infradiaphragmatic pulmonary venous connection. He had required implantation of stents in the left and right sided pulmonary veins at 7

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Corrigendum: Case report: Selexipag in pediatric pulmonary hypertension: initiation, transition, and titration

Jenna M. Faircloth, Neelam D. Bhatt, Corey A. Chartan, Ryan D. Coleman, Natalie Villafranco, Fadel E. Ruiz, Raysa Morales-Demori, Elise Whalen, Erin Ely, Rozmeen Fombin, Nidhy P. VargheseTexas Children’s Hospital and Baylor College of Medicine.United States Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1275389 AbstractThis corrects the article DOI: 10.3389/fped.2023.1050508. CategoryClass I. Idiopathic Pulmonary HypertensionClass I. Heritable

Corrigendum: Case report: Selexipag in pediatric pulmonary hypertension: initiation, transition, and titration Read More »

The small-molecule formyl peptide receptor biased agonist, Compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices

William R. Studley, Emma Lamanna, Katherine A. Martin, Claudia A. Nold-Perry, Simon G. Royce, Owen L. Woodman, Rebecca H. Ritchie, Cheng Xue Qin, Jane E. BourkeMonash University. Hudson Institute of Medical Research. Baker Heart and Diabetes Institute.Australia British Journal of PharmacologyBr J Pharmacol 2023; DOI: 10.1111/bph.16231 AbstractBackground and purpose: Pulmonary arterial hypertension (PAH), a rare but fatal

The small-molecule formyl peptide receptor biased agonist, Compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices Read More »

Prevalence of malnutrition in pediatric pulmonary hypertension cohort and role for registered dietitian involvement

Presley R. Crowell, Mackenzie R. Frederick, Rozmeen A. Fombin, Nidhy P. Varghese, Fadel E. RuizTexas Children’s Hospital and Baylor College of Medicine.United States Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.995470 AbstractIntroduction: Pediatric pulmonary hypertension (PH) is a serious condition with increased risk for malnutrition due to increased caloric needs and reduced energy intake. This combination of disease

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Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph KnosallaDeutsches Herzzentrum der Charité. Charité-Universitätsmedizin Berlin. Freie Universität Berlin and Humboldt-Universität zu

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease Read More »

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