Medical Therapy. Efficacy or Lack of Efficacy

Pulmonary vasodilators and exercise in Fontan circulation: a systematic review and meta-analysis

Diamantis Kosmidis, Alexandra Arvanitaki, Ioannis T Farmakis, Aris Liakos, Andreas Giannopoulos, Antonios Ziakas, George GiannakoulasAristotle University of Thessaloniki. Royal Brompton Hospital. University Medical Center Mainz. Greece, United Kingdom and Germany HeartHeart 2023; DOI: 10.1136/heartjnl-2023-323166 AbstractObjective: In Fontan circulation, pulmonary arterial hypertension (PAH)-targeted therapies could improve the patients’ exercise capacity. This study aimed to investigate the effects of PAH […]

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CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension

Abraham Rothman, Humberto Restrepo, William N. Evans, Valeri Sarukhanov, David MannUniversity of Nevada Las Vegas. Vascular BioSciences.United States Open Respiratory Medicine JournalOpen Respir Med J 2023; DOI: 10.2174/18743064-v17-e230404-2022-19 AbstractBackground: Despite the approval of several medications for pulmonary hypertension, morbidity and mortality are unacceptably high. Systemic hypotension may limit the use of pulmonary hypertension medications.Objectives: This study aimed to

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Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension

Joseph M. Collaco, Steven H. Abman, Eric D. Austin, Catherine M. Avitabile, Angela Bates, Jeffrey R. Fineman, Grace A. Freire, Stephanie S. Handler, Dunbar D. Ivy, Usha S. Krishnan, Mary P. Mullen, Nidhy P. Varghese, Delphine Yung, Melanie K. Nies, Allen D. Everett, Kanecia O. Zimmerman, William Simmons, Hrishikesh Chakraborty, Gayane Yenokyan, Allison Newell‐Sturdivant, Eric

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Rapidly Progressive Idiopathic Pulmonary Arterial Hypertension in a Paediatric Patient Treated with Lung Transplantation

Filip Baszkowski, Weronika Pelczar-Płachta, Nikola Pempera, Sylwia Sławek-Szmyt, Marta Kałuzna-Oleksy, Maciej Lesiak, Waldemar BobkowskiPoznan University of Medical Sciences.Poland DiagnosticsDiagnostics 2023; DOI: 10.3390/diagnostics13203185 AbstractPulmonary arterial hypertension (PAH) is a rare heterogeneous disorder in the paediatric population which is mostly associated with congenital heart disease. The management of paediatric idiopathic PAH (IPAH) is difficult due to insufficient comparative

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Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN)

Irfan Shehzad, Ashish Banker, Bibhuti Das, Adil Humayun, Hale Wills, Muppala Raju, Niraj VoraBaylor Scott & White Health.United States CureusCureus 2023; DOI: 10.7759/cureus.45595 AbstractDespite improvements in the medical management of persistent pulmonary hypertension of the newborn (PPHN), a significant number of patients persist with inadequate gas exchange and are treated with extracorporeal membrane oxygenation (ECMO). Prolonged

Successful Weaning From Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) After Initiation of Inhaled Epoprostenol in a Neonate With Refractory Persistent Pulmonary Hypertension of the Newborn (PPHN) Read More »

Preoperative Sildenafil in Pediatric Patients Undergoing Congenital Heart Surgeries: A Systematic Review and Meta-Analysis

Yusuf Ananda Fikri, Eka Prasetya Budi Mulia, Faris Wahyu NugrohoDr. R. Soetrasno Regional General Hospital.Indonesia Seminars in Cardiothoracic and Vascular AnesthesiaSemin Cardiothorac Vasc Anesth 2023; DOI: 10.1177/10892532231205752 AbstractBackground. Pulmonary hypertension (PH) is a common complication of congenital heart disease (CHD). With early surgical intervention, outcomes have improved over the last two decades. Persistent PH, however, may still

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Home-inhaled nitric oxide in a child with pulmonary arterial hypertension associated with post-operative pulmonary venous obstruction

Yuichiro Sugitani, Jun Muneuchi, Mamie WatanabeKyushu Hospital and Japan Community Healthcare Organization.Japan Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123003591 AbstractHome-inhaled nitric oxide therapy was effective and feasible in the patients with intractable pulmonary arterial hypertension. We present the case of a child with severe pulmonary arterial hypertension associated with post-operative pulmonary venous obstruction who was

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A Neonate With Cytokine Storm Managed With Steroids, Therapeutic Plasma Exchange, and Tocilizumab

Amy LiKamWa, Kaitlin Kobaitri, Balagangadhar R. TotapallyHerbert Wertheim College of Medicine. Nicklaus Children’s Hospital.United States CureusCureus 2023; 15DOI: 10.7759/cureus.45138 AbstractNeonatal cytokine storms, though rare, can induce hyperinflammation due to elevated interleukin-6 (IL-6), triggering multiorgan failure. We present the case of a term male neonate necessitating extracorporeal membrane oxygenation (ECMO) post-birth for persistent pulmonary hypertension due to

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Comparison of mortality and short-term outcomes between classic, intubation-surfactant-extubation, and less invasive surfactant administration methods of surfactant replacement therapy

Seung Yeon Kim, Jiseun Lim, Gyu-Hong ShimNowon Eulji Medical Center and Eulji University School of Medicine. Inje University Sanggye Paik Hospital.Republic of Korea Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1197607 AbstractBackground: Intubation-Surfactant-Extubation (InSurE) and less invasive surfactant administration (LISA) are alternative surfactant replacement therapy methods for reducing the complications associated with invasive mechanical ventilation. This study aimed

Comparison of mortality and short-term outcomes between classic, intubation-surfactant-extubation, and less invasive surfactant administration methods of surfactant replacement therapy Read More »

Use of Bosentan in neonatal post cardiac surgery pulmonary hypertension

Ravindra Pawar, Pankaj Kasar, Swati Garekar, Snehal KulkarniWockhardt Hospital.India Annals of Pediatric CardiologyAnn Pediatr Cardiol 2009; 2: 173-174DOI: 10.4103/0974-2069.58325 AbstractWe report the use of Bosentan in the post-operative period of a neonate with obstructed infradiaphragmatic total anomalous pulmonary venous connection and severe pulmonary arterial hypertension. To our knowledge, this is the first report of use of

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