Medical Therapy. Efficacy or Lack of Efficacy

Nasopharyngeal ventilation: an answer to the conundrum of severe nasal injury in a neonate

Bhabesh Kant Chowdhry, Arnab Ghorui, Richie Dalai, Rameshwar PrasadAll India Institute of Medical Sciences.India British Medical Journals Case ReportsBMJ Case Rep 2025; 18:DOI: 10.1136/bcr-2025-264797 AbstractA term neonate with a stormy perinatal course, requiring prolonged mechanical ventilation, due to congenital pneumonia, complicated by secondary pulmonary arterial hypertension and prolonged non-invasive respiratory support, presented to us in the […]

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Respiratory Support Strategies for Surgical Neonates: A Review

Piero Alberti, Niyi Ade-Ajayi, Anne GreenoughKing’s College London.United Kingdom ChildrenChildren 2025; 12: DOI: 10.3390/children12030273 AbstractNeonates with congenital conditions which require surgical management frequently experience respiratory distress. This review discusses the management of pulmonary complications and the respiratory support strategies for four conditions: oesophageal atresia-tracheoesophageal fistula (OA-TOF), congenital diaphragmatic hernia (CDH), congenital lung malformations (CLM), and anterior

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Intraamniotic Vitamin D Preserves Lung Development and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia due to Intraamniotic sFlt-1

Michael W. Cookson, Tania Gonzalez, Elisa M. Bye, Greg Seedorf, Sarah Ellor, Brad J. Smith, James C. Fleet, Erica W. MandellUniversity of Colorado, Anschutz School of Medicine and Children’s Hospital Colorado. University of Texas.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00409.2024 AbstractPreterm infants born

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Trametinib as a targeted treatment in cardiac and lymphatic presentations of Noonan syndrome

Isabel De Brouchoven, Juan Lorand, Léon Bofferding, Arthur Sorlin, An Van Damme, Olivier DanhaiveSaint-Luc University Hospital,. Luxembourg Hospital Center. Laboratoire National de Santé. University of California San Francisco.Belgium, Luxembourg and United States Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1475143 AbstractIntroduction: Rare pathogenic variants in the PTPN11, KRAS, SOS1 and RAF1 genes are the main molecular causes of Noonan syndrome (NS).

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Clinical characteristics and impact of exchange transfusion in infant pertussis with extreme leukocytosis

Yuanyuan Wu, Chuan GanSecond Affiliated Hospital of Chongqing Medical University, Children’s Hospital of Chongqing Medical University and Chongqing Medical University. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity.China Italian Journal of PediatricsItal J Pediatr 2025; 51: DOI: 10.1186/s13052-025-01933-9 AbstractBackground: Extreme leukocytosis in pertussis is a rare condition, and without effective interventions to reduce white

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Macitentan: Pediatric First Approval

Susan J. KeamSpringer Nature.New Zealand Paediatric DrugsPaediatr Drugs 2025; DOI: 10.1007/s40272-025-00692-8 AbstractMacitentan (Opsumit®), an endothelin receptor antagonist (ERA) developed by Johnson & Johnson, is well established worldwide as monotherapy or combination therapy for the long-term treatment of pulmonary arterial hypertension (PAH). In September 2024, based on phase 3 clinical data in patients aged < 18 years,

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Sodium nitrite prevents impaired postnatal alveolar development

Kathrine L. Daniel, Chantal Gaudet, Ali Hamraghani, Nadya Ben Fadel, Behzad Yeganeh, Robert P. JankovChildren’s Hospital of Eastern Ontario Research Institute. University of Ottawa.Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00324.2024 AbstractDeficient nitric oxide (NO) signaling plays a critical role in the pathogenesis of bronchopulmonary

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Long-term survival of shunt closure in atrial septal defects with pulmonary arterial hypertension

Wenjie Chen, Jingyuan Chen, Min Peng, Jun Luo, Haihua Qiu, Yusi Chen, Jiang LiSecond Xiangya Hospital of Central South University. China International Journal of CardiologyInt J Cardiol 2025; DOI: 10.1016/j.ijcard.2025.133094 AbstractObjective: This study aims to refine closure indications and assess long-term outcomes in pulmonary arterial hypertension associated with atrial septal defect (PAH-ASD).Methods: We enrolled 197 PAH-ASD patients classified

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Ultrasonographic diagnosis and follow-up of a special type of giant fetal hepatic hemangioma

Xiaoyan Weng, Juan Jiang, Gang WenWomen and Children’s Hospital Affiliated to Ningbo University. China Pediatric RadiologyPediatr Radiol 2025; DOI: 10.1007/s00247-025-06196-4 AbstractWe present a case of giant fetal hepatic hemangioma to illustrate the impact of ultrasound monitoring on treatment outcomes. Prenatal ultrasound revealed cardiac enlargement, leading to a cesarean section. The neonate had multiple vascular anomalies, including

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Severe Precapillary Pulmonary Hypertension and Right Ventricular Failure After Hematopoietic Stem Cell Transplantation: Successful Outcomes With Aggressive Upfront Triple Therapy

Stine Andersen, Jesper Vandborg Bjerre, Karin Baekgaard, Lars Idorn, Mads Jønsson AndersenAarhus University Hospital and Aarhus University. Copenhagen University Hospital.Denmark Pediatric Blood and CancerPediatr Blood Cancer 2025; DOI: 10.1002/pbc.31623 AbstractAbstract Not Available CategoryClass V. Pulmonary Hypertension Associated with Hematological, Systemic, Metabolic and Other DisordersMedical Therapy. Efficacy or Lack of Efficacy Age Focus: Pediatric Pulmonary Vascular Diseasec

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