Medical Therapy. Efficacy or Lack of Efficacy

Milrinone in persistent pulmonary hypertension of newborn: a scoping review

Radu Galis, Diane Mudura, Paula Trif, Shivashankar Diggikar, Arun Prasath, Maria Livia Ognean, Jan Mazela, Adrian Lacatusu, Rangasamy Ramanathan, Boris W. Kramer, Yogen SinghEmergency County Hospital Bihor. Poznan University of Medical Sciences. University of Oradea. Oyster Woman and Child Hospital. University of Texas Southwestern. Lucian Blaga University Sibiu. Clinical County Emergency Hospital Sibiu. Emergency County […]

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Selexipag Dosing Strategies for Pediatric Patients with Pulmonary Arterial Hypertension

Madeline Grossman, Stephen Walker, E. Zachary RamseyChildren’s Hospital of Philadelphia.United States Pediatric CardiologyPediatr Cardiol 2024; DOI: 10.1007/s00246-024-03513-w AbstractThis retrospective chart review of patients less than 18 years old with pulmonary arterial hypertension (PAH) receiving selexipag was conducted to describe selexipag dosing practices, impact on concomitant PAH therapies, and the safety and efficacy of selexipag. Twenty-seven patients

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Effect of prone positioning ventilation on pulmonary function in neonates during venous-arterial extracorporeal membrane oxygenation

Kai-Peng Sun, Si-Jia Zhou, Xiu-Hua Chen, Yi-Rong Zheng, Qiang ChenFujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center) and Fujian Medical University.China Translational PediatricsTransl Pediatr 2024; 13: 575-583DOI: 10.21037/tp-23-485 AbstractBackground: The use of extracorporeal membrane oxygenation (ECMO) technology has significantly decreased mortality rates associated with neonatal pulmonary hypertension and respiratory failure. Prone positioning ventilation (PPV) is

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Tailoring of Bilosomal Nanogel for Augmenting the Off-Label Use of Sildenafil Citrate in Pediatric Pulmonary Hypertension

Bjad K. Almutairy, El-Sayed Khafagy, Mohammed F. Aldawsari, Abdullah Alshetaili, Hadil Faris Alotaibi, Amr Selim Abu LilaPrince Sattam Bin Abdulaziz University. Suez Canal University. Princess Nourah Bint AbdulRahman University. Zagazig University. University of Hail.Saudi Arabia and Egypt American Chemical Society OmegaACS Omega 2024; 9: 19536-19547DOI: 10.1021/acsomega.4c01133 AbstractPediatric pulmonary hypertension is a serious syndrome with significant morbidity

Tailoring of Bilosomal Nanogel for Augmenting the Off-Label Use of Sildenafil Citrate in Pediatric Pulmonary Hypertension Read More »

Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

Liqun Ning, Stefano Zanella, Martin M. Tomov, Medhi Salar Amoli, Linqi Jin, Bouen Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmooudi, Holly D. Bauser-Heaton, Vahid SerpooshanEmory University School of Medicine, Children’s Healthcare of Atlanta and Georgia Institute of Technology. Cleveland State University. Texas A&M University. Michigan State University. United

Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins Read More »

Successful Atrial Septal Defect Closure Subsequent to Medical Pulmonary Preconditioning in an Infant With Severe Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia

Maki Sato, Hirofumi Saiki, Kanchi Saito, Akira Sato, Seiko Kuwata, Satoshi Nakano, Junichi Koizumi, Kotaro Oyama, Manami AkasakaIwate Medical University. Michinoku Medical Center on Disability and Health.Japan CureusCureus 2024; 16: DOI: 10.7759/cureus.57290 AbstractWhile atrial septal defect (ASD) may contribute to right ventricular decompression in patients with severe pulmonary hypertension (PH), the pulmonary vasculature might be compromised

Successful Atrial Septal Defect Closure Subsequent to Medical Pulmonary Preconditioning in an Infant With Severe Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia Read More »

Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells

Yi-Ching Liu, Yu-Hsin Tseng, Yu-Hsin Kuan, Lin-Yen Wang, Shang-En Huang, Siao-Ping Tsai, Iwu-Lai Yeh, Jong-Hau HsuKaohsiung Medical University Hospital and Kaohsiung Medical University. E-Da Hospital and I-Shou University. National Sun Yat-sen University. Chia Nan University of Pharmacy and Science. Taiwan Kaohsiung Journal of Medical ScienceKaohsiung J Med Sci 2024; DOI: 10.1002/kjm2.12835 AbstractPulmonary vascular remodeling is a

Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells Read More »

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells Read More »

Cough-induced chylothorax in a two-year-old boy – case report and review of the literature

Melanie Anger, Julian Hofmann, Bettina Ruf, Marc Steinborn, Daniela Reber, Katharina Warncke, Nikolaus RieberKinderklinik München Schwabing, Munich Klinik and School of Medicine and Technical University of Munich. Germany BioMed Central PediatricsBMC Pediatr 2023; 23:DOI: 10.1186/s12887-023-04221-9 AbstractBackground: Chylothorax is a very rare form of pleural effusion in children, especially after the neonatal period, and predominantly occurs secondary to cardiothoracic

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Chylothorax related to acute SARS-CoV-2 infection in a patient with Noonan syndrome with prior uncomplicated cardiac surgeries

Lubaina Ehsan, Jessica A. Thoe, John J. Parent, Joseph D. FakhouryWestern Michigan University Homer Stryker M.D, School of Medicine and Bronson Children’s Hospital. Indiana University School of Medicine.United States Cardiology in the YoungCardiol Young 2024; 34: 448-451DOI: 10.1017/S1047951123004171 AbstractSARS-CoV-2 is a novel coronavirus that has rarely been associated with chylothorax. Patients with Noonan syndrome are at

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