Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway

Zongbin Li, Miao Zhao, Shanshan Ma, Shuyu LeiThird People’s Hospital of Xinjiang Uygur Autonomous Region. China European Journal of Medical ResearchEur J Med Res 2025; DOI: 10.1186/s40001-025-03586-0 AbstractBackground: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) drives lethal pulmonary vascular remodeling. While circular RNAs (circRNAs) are emerging as disease regulators, their functional roles in PAH-CHD remain […]

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway Read More »

Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage

He Zhang, Sixie Zheng, Zheng Wang, Yingying Xiao, Yuqing Hu, Debao Li, Qing Cui, Chenxi Liu, Yiting Xue, Junhua Wu, Sijuan Sun, Lincai YeAffiliated Women and Children’s Hospital of Ningbo University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China Cell

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Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications

Xiaoyu Zhang, Liming Cheng, Jiahui Xie, Xuejuan Ma, Wenting Gui, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Kunming Children’s Hospital, Chinese Academy of Medical Sciences and Affiliated Cardiovascular Hospital of Kunming Medical University. China Frontiers in PhysiologyFront Physiol 2025; 14: DOI: 10.3389/fphys.2025.1673181 AbstractBackground: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vascular remodeling

Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications Read More »

Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat

Bingbing Ye, Danyan Su, Yuqin Huang, Dongli Liu, Yanyun Huang, Suyuan Qin, Cheng Chen, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University.China Clinical and Experimental HypertensionClin Exp Hypertens 2025; 47: DOI: 10.1080/10641963.2025.2583193 AbstractThis study was designed to elucidate the role of circPcmtd1 in regulating pulmonary artery smooth muscle cells (PASMCs) proliferation and migration, through the HSP90AB1/AKT

Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat Read More »

Role of lipid droplets in pulmonary arterial hypertension: focusing on pulmonary artery smooth muscle cell proliferation

Baishi Huang, Yu Hao, Zhe Wen, Jie Dong, Shengwei Jin, Hui LiSecond Affiliated Hospital, Yuying Children’s Hospital and Wenzhou Medical University. China Lipids in Health and DiseaseLipids Health Dis 2025; 24:DOI: 10.1186/s12944-025-02746-9 AbstractPulmonary arterial hypertension (PAH) is a devastating disease complicated by pathological features such as proliferation of pulmonary artery smooth muscle cells (PASMCs), vasoconstriction, increased

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Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension

Christine L. Farrell, Mariah Jordan, Janelle N. Posey, Kimberly R. Jordan, Aneta Gandjeva, Eva S. Nozik, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham, Cassidy A. DelaneyUniversity of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of California San Francisco.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70174 AbstractUsing lung immunohistochemistry and stereology, platelets

Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension Read More »

Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension

Shyam Thapa, Poonam Sarkar, M. Waleed Gaber, Roberto Barrios, Madhulata Chauhan, Chandrasekhar Yallampalli, Binoy ShivannaTexas Children’s Hospital and Baylor College of Medicine. Houston Methodist HospitalUnited States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00234.2025 AbstractBronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH) or BPD-PH is a lung

Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension Read More »

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH

Abdul S. Mahomed, Anne Burke-Gaffney, Shahin Moledina, Quezia K.Toe, Dongmin Shao, Gregory J. Quinlan, Christopher J. Rhodes, James E. Pease, Stephen JohnWortImperial College London. Great Ormond Street Hospital for Children NHS Foundation Trust. Royal Brompton Hospital.United Kingdom Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-16418-2 AbstractPulmonary arterial hypertension (PAH) is a progressive pulmonary vasculopathy characterized by extensive

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH Read More »

The Effect of Microvascular Remodeling on Fluid Dynamics in the Pressure Overloaded Right Ventricle

Ilham Essafri, Kenzo Ichimura, Dunbar Ivy, Kurt R. Stenmark, Helena A. Turton, Laura L. Pyle, Edda Spiekerkoetter, Vitaly O. KheyfetsUniversity of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. Stanford University, Stanford. United States American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2025; DOI: 10.1152/ajpheart.00147.2025 AbstractRight ventricular (RV) failure, a major

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Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension

Jun-Zhuo Shi, Yong-Jian Zhu, Meng-Jie Zhang, Yi Yan, Lu-Ling Zhao, Hong-Da Zhang, Yan Liu, Wen-Hui Wu, Zhe Cheng, Chun-Guang Qiu, Jie-Jian Kou, Yun-Feng Zhou, Xiao-Bin Pang, Ji-Wang Chen, Xin-Mei Xie, Yang-Yang He, Zhi-Cheng JingHuaihe Hospital and Henan University. First Affiliated Hospital of Zhengzhou University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao

Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension Read More »

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