Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Metabolic reprogramming in pulmonary arterial hypertension

Jun-Zhuo Shi, Jing-Song Ye, Xiao-Rui An, Guo Cheng, Xin Fan, Fang-Fang Meng, Ou Yang, Yang-Han-Yue Zhou, Meng-Jie Zhang, Tian-Yi Yuan, Yi Yan, Yang-Yang HeHuaihe Hospital and Henan University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Chinese Academy of Medical Sciences and Peking Union Medical College. Pharmacology and TherapeuticsPharmacol Ther 2026;

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Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia

Heleen M. Kool, Petra E. Bürgisser, Gabriela G. Edel, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Wilfred F. J. Ijcken, Robbert J. RottierSophia Children’s Hospital. Erasmus Medical Center. Democritus University of Thrace. Netherlands and Greece Cellular and Molecular Life SciencesCell Mol Life Sci 2026; DOI: 10.1007/s00018-026-06319-6 AbstractCongenital diaphragmatic hernia (CDH) is a rare

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Inhibition of thrombospondin-1 signaling prevents experimental bronchopulmonary dysplasia

Chantal Gaudet, Kathrine L. Daniel, Sophie Holcik, Ali Hamraghani, Behzad Yeganeh, Robert P JankovChildren’s Hospital of Eastern Ontario. University of Ottawa. Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00090.2026 AbstractBronchopulmonary dysplasia (BPD) is a neonatal lung injury characterized by inflammation, and alveolar and vascular hypoplasia

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KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension

Rehab Alharbi, Merve Keles, Nadia Fernandes, Hannah Maude, Adam Fellows, Richard D. Williams, Chien-Nien Chen, Nathalie Lambie, Nik Matthews, May Al-Sahaf, Sam N. Barnett, Minzhe Guo, Lan Zhao, Allan Lawrie, Jeffrey A. Whitsett, Inês Cebola, Beata Wojciak-StothardImperial College London. University of Hafr Al Batin. Hammersmith Hospital. Cincinnati Children’s Hospital Medical Center and University of Cincinnati

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Contemporary Endothelial Genome Editing Technologies: Towards Precision Genetic Medicine for Vascular Diseases

You-Yang Zhou, Colin E. EvansAnn and Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. United States International Journal of Molecular SciencesInt J Mol Sci 2026; 27: DOI: 10.3390/ijms27115100 AbstractEndothelial dysfunction is a key characteristic of many diseases, including atherosclerosis, hypertension, heart failure, stroke, cancer, acute respiratory distress syndrome (ARDS), peripheral

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A Biomimetic Miniaturized In Vitro Model to Target Early Markers of Neonatal Pulmonary Vascular Injury

Motaharehsadat Heydarian, Ali Doryab, Juan Henao, Benjamin Schubert, Otmar Schmid, Anne HilgendorffHelmholtz Zentrum München and German Lung Research Center. University of Cambridge. University Hospital Ludwig-Maximilian University. Carl von Ossietzky University.Germany and United Kingdom American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00002.2026 AbstractPulmonary vascular disease (PVD) is

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Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension

M. Elizabeth Moss, Timothy Klouda, Yan Li, Yu Liu, Meng Tan, Yunhye Kim, Yuan Hao, Mark R. Nicolls, Joseph C. Wu, Richard Bucala, Hong Chen, Eungjoo Lee, Karin Tran-Lundmark, Benjamin Raby, Ke YuanBoston Children’s Hospital and Harvard Medical School. Stanford University. University of California, San Diego. Yale School of Medicine. University of Arizona. Lund University

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Cx43 mediates nicotine-induced enhancement of mouse pulmonary arterial tone by downregulating Kv1.2 and Kv2.1 channels

Xiaomin Hou, Xuelu Jiang, Xin Meng, Jin Zhou, Di Xi, Xiaoxia Ren, Ming Gao, Yong’e Liu, Xiao Luo Yiwei Shi, Xiaojiang QinShanxi Medical University. China-Japan Friendship Hospital. Shanxi Coal Central Hospital. First hospital of Shanxi Medical University. China Food and Chemical ToxicologyFood Chem Toxicol 2026; DOI: 10.1016/j.fct.2026.116182 AbstractPulmonary hypertension (PH) is a chronic and complex condition

Cx43 mediates nicotine-induced enhancement of mouse pulmonary arterial tone by downregulating Kv1.2 and Kv2.1 channels Read More »

Variation in SNX29 and Acute Vasodilator Response in Pulmonary Arterial Hypertension

Jason H. Karnes, Changlei Bao, Shuxin Liang, Timothy Thayer, John Zagorski, Samisubbu R. Naidu, James D. West, Rae-Hwi Schwantes-An, Ehsan Khajouei, Kasturi Banerjee, Hemant K. Tiwari, Juvie Farol, Kiana L. Martinez, Dingyuan Liu, Yao Ning, Yanan Sun, Yangfan Jia, Jian Wang, Amit Arora, Ken Batai, Stephen J. Halliday, Katie Lutz, Anna Walsworth, Andrea L. Frump,

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Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension

Yong‐Jian Zhu, Jie‐Jian Kou, Ya‐Cong Bo, Meng‐Jie Zhang, Xin Fan, Lu‐Ling Zhao, Yi Yan, Hong Da Zhang, Wen‐Hui Wu, Ping Yuan, Yan Liu, Jun‐Zhuo Shi, Xiao‐Bin Pang, Yang‐Yang HeFirst Affiliated Hospital of Zhengzhou University. Huaihe Hospital and Henan University. Zhengzhou University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Fuwai Hospital and Peking Union Medical College. Shanghai Pulmonary Hospital and School of Medicine Tongji University. China Journal of the American Heart AssociationJ Am Heart Assoc

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension Read More »

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