Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

A circulating MicroRNA signature for the diagnosis of pulmonary arterial hypertension and functional characterization of candidate miR-3168

Mauro Lago-Docampo, Ainhoa Iglesias-López, Carlos Vilariño, Adolfo Baloira, Joan Albert Barberá, Isabel Blanco, Diana ValverdeUniversidade de Vigo. Galicia Sur Health Research Institute. Hospital Povisa. Complejo Hospitalario Universitario de Pontevedra. University of Barcelona. Stanford University School of Medicine.Spain and United States Scientific ReportsSci Rep 2026; DOI: 10.1038/s41598-026-42550-8 AbstractPulmonary Arterial Hypertension (PAH) is a rare, progressive disorder characterized […]

A circulating MicroRNA signature for the diagnosis of pulmonary arterial hypertension and functional characterization of candidate miR-3168 Read More »

Decreased AMP-Kinase Function in Pulmonary Artery Smooth Muscle Cells Contributes to Pulmonary Artery Remodeling in Persistent Pulmonary Hypertension of Newborn

Emily A. Mooers, Ujala Rana, Chintamani N. Joshi, Adeleye J. Afolayan, Ru-Jeng Teng, Girija Ganesh KonduriMedical College of Wisconsin. United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00229.2025 AbstractPulmonary vascular remodeling contributes to Persistent Pulmonary Hypertension of the Newborn (PPHN); the mechanisms remain unknown. 5’AMP-Activated

Decreased AMP-Kinase Function in Pulmonary Artery Smooth Muscle Cells Contributes to Pulmonary Artery Remodeling in Persistent Pulmonary Hypertension of Newborn Read More »

Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities

Brooke Dir, Raveena Mishra, Nicole Hennen, Emily Mooers, Ru-jeng Teng, Ganesh Konduri, Jeffrey L. Segar, Justin Grobe, Matthew R. Hodges, Gary C. MouradianMedical College of Wisconsin. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2026; DOI: 10.1093/ajrcmb/aanag031 AbstractThe severity of bronchopulmonary dysplasia (BPD) is defined by the type or

Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities Read More »

GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation

Ruoxuan Jiang, Liuyi Li, Yuhang Luo, Wen Wang, Xiaoya Zeng, Cheng Qian, Chen Gong, Jianlong ShenSecond Affiliated Hospital of Anhui Medical University. First Affiliated Hospital of Anhui Medical University. China International ImmunopharmacologyInt Immunopharmacol 2026; DOI: 10.1016/j.intimp.2026.116394 AbstractPulmonary arterial hypertension (PAH) is a fatal disease marked by pulmonary vascular remodeling. Although endothelial dysfunction and immune cell infiltration

GM-CSF exacerbates pulmonary arterial hypertension via CCL2/CCR2-axis-mediated macrophage NLRP3 inflammasome activation Read More »

Estriol attenuates visceral adiposity and pulmonary artery smooth muscle cell proliferation via ERα-mediated signalling

Smriti Sharma, Joshua P. Dignam, Gregor Aitchison, Rosemary Gaw, Ioannis Stasinopolous, Ayman Gebril, Martin Wabitsch, Ruth Andrew, Margaret R. MacLeanUniversity of Strathclyde. Medical University of Vienna. Barts and The London School of Medicine and Dentistry and Queen Mary University of London. University of Edinburgh. Ulm University Medical Center. German Center for Child and Adolescent Health.United

Estriol attenuates visceral adiposity and pulmonary artery smooth muscle cell proliferation via ERα-mediated signalling Read More »

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty-QuintanaMcGovern Medical School University and McWilliams School of Biomedical Informatics of

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response Read More »

Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension

Viranuj Sueblinvong, Sarah S. Chang, Jing Ma, David R. Archer, Solomon Ofori-Acquah, Roy L. Sutliff, Changwon Park, C. Michael Hart, Benjamin T. Kopp, Bum-Yong KangEmory University School of Medicine. Atlanta Veterans Affairs Healthcare System. National Institutes of Health. Louisiana State University Health Science Center. United States CellsCells 2026; 15: DOI: 10.3390/cells15020154 AbstractPulmonary hypertension (PH) causes morbidity

Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension Read More »

Histone deacetylase 3 promotes hypoxia-induced human pulmonary arterial smooth muscle cell proliferation by modulating the CSF2-JAK2-STAT5 signaling pathway

Jie Zhang, Youfei Fan, Yanting Gao, Youpeng JinShandong Provincial Hospital and Second Affiliated Hospital Affiliated to Shandong First Medical University. China Human CellHum Cell 2026; 39: DOI: 10.1007/s13577-026-01348-6 AbstractThe growth of human pulmonary arterial smooth muscle cells (hPASMCs) is one of the key contributors to vascular remodeling in pulmonary arterial hypertension (PAH). Although histone deacetylase 3

Histone deacetylase 3 promotes hypoxia-induced human pulmonary arterial smooth muscle cell proliferation by modulating the CSF2-JAK2-STAT5 signaling pathway Read More »

Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets

MengzeWang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie DingKunming Children’s Hospital. Southern Medical University. Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Taizhou Central Hospital (Taizhou University Hospital). Second Hospital of Jiaxing and Second Affiliated Hospital of Jiaxing University. Zhejiang Rongjun Hospital.

Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets Read More »

Generation of 5 hiPSC lines from pediatric patients with Heritable pulmonary arterial hypertension (HPAH) caused by heterozygous mutations in the TBX4 gene

Valeria Fernandez Vallone, Kristin Fischer, Judit Küchler, Franziska Diekmann, Georg Hansmann, Harald StachelscheidBerlin Institute of Health at Charité – Universitätsmedizin Berlin. Hannover Medical School. Children’s Hospital, General Hospital Vienna, Medical University of Vienna. European Pediatric Pulmonary Vascular Disease Network.Germany and Austria Stem Cell ResearchStem Cell Res 2025; DOI: 10.1016/j.scr.2025.103886 AbstractHeritable pulmonary arterial hypertension (HPAH) and underlying

Generation of 5 hiPSC lines from pediatric patients with Heritable pulmonary arterial hypertension (HPAH) caused by heterozygous mutations in the TBX4 gene Read More »

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