Pulmonary Vascular Pathology

Pulmonary arteriole narrowing in end-stage cystic fibrosis lungs occurs with and without small airway disease

Astrid Vermaut, Gitte Aerts, Lynn Willems, Vincent Geudens, Charlotte Hooft, Pieterjan Kerckhof, Lise Vanvuchelen, Marta Zapata-Ortega, Hanne Beeckmans, Xin Jin, Yousry Mohamady, Jan Van Slambrouck, Lucia Aversa, Janne Verhaegen, Emanuela E. Cortesi, Charlotte De Fays, Birgit Weynand,Dirk E. Van Raemdonck, Laurens J. Ceulemans, Wim A. Wuyts, Marianne Carlon, Robin Vos, Natalie Lorent, Ghislaine Gayan-Ramirez, Laurent […]

Pulmonary arteriole narrowing in end-stage cystic fibrosis lungs occurs with and without small airway disease Read More »

Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice

Yi Jin, Bernadette Chen, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00202.2024 AbstractBronchopulmonary dysplasia (BPD) is a common chronic lung disease in pediatrics. Neonatal mice placed in hyperoxia (85% oxygen, HYP) develop lung injury

Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice Read More »

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. NozikUniversity of Colorado, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of Nebraska Medical Center.United States American Journal of

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia Read More »

Prominent Intrapulmonary Shunt Vessels and Altered Lung Development in Infants With Sudden Unexplained Infant Death

Csaba Galambos, Douglas Bush, Steven H. Abman, Michael CaplanUniversity of Colorado School of Medicine. Icahn School of Medicine at Mount Sinai. Lake Erie College of Osteopathic Medicine.United States Journal of PediatricsJ Pediatr 2023; DOI: 10.1016/j.jpeds.2022.10.026 AbstractThe purpose of this study was to evaluate intrapulmonary arteriovenous shunts in patients with and without sudden unexplained infant death. We

Prominent Intrapulmonary Shunt Vessels and Altered Lung Development in Infants With Sudden Unexplained Infant Death Read More »

Different Effects of Riociguat and Vericiguat on Pulmonary Vessels and Airways

Katharina Nubbemeyer, Julia Krabbe, Svenja Böll, Anna Michely, Sebastian Kalverkamp, Jan Spillner, Christian MartinRWTH Aachen University. Ruhr University Bochum. Germany BiomedicinesBiomedicines 2025; 13: DOI: 10.3390/biomedicines13040856 AbstractBackground/Objectives: Pulmonary hypertension is a progressive disease leading to right heart failure. One treatment strategy is to induce vasodilation via the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway. There

Different Effects of Riociguat and Vericiguat on Pulmonary Vessels and Airways Read More »

Performance of oral Bosentan-loaded SNEDDS and S-SNEDDS tablets: Biodistribution in mice, echocardiography and histology studies in pulmonary arterial hypertension rat model

Duygu Yilmaz Usta, Seval Olgac, Murside Ayse Demirel, Serdar Kula, Cigdem Elmas, Perihan Sezginer, Akif Kavgaci, Zeynep Safak TeksinGazi University. Alanya Alaadin Keykubat University. Turkey European Journal of Pharmaceutics and BiopharmaceuticsEur J Pharma Biopharma 2025; DOI: 10.1016/j.ejpb.2025.114725 AbstractBosentan monohydrate (BOS) is the most preferred molecule for treating the rare pulmonary arterial hypertension (PAH) disease. BOS shows

Performance of oral Bosentan-loaded SNEDDS and S-SNEDDS tablets: Biodistribution in mice, echocardiography and histology studies in pulmonary arterial hypertension rat model Read More »

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension

Bahram Mirani, John D. Dauz, Kana Yazaki, Neda Latifi, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergUniversity of Toronto, Ted Rogers Centre for Heart Research and Hospital for Sick Children. Beth Israel Deaconess Medical Center and Harvard Medical School. University of South Florida.Canada and United States Arteriosclerosis, Thrombosis and Vascular BiologyArterioscler,

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension Read More »

Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension

Christian Westöö, Ayse Ceren Mutgan, Oscar van der Have, Timothy J. Mead, Salaheldin Ahmed, Elna Lampei, Christopher D. Koch, Christian Norvik, Anders Aspberg, Martin Bech, Niccolò Peruzzi, Hans Brunnström, Grazyna Kwapiszewska, Göran Rådegran, Suneel S. Apte, Karin Tran-LundmarkLund University. Medical University of Graz. Skåne University Hospital. Cleveland Clinic Lerner Research Institute. Case Western Reserve University. University Hospitals Rainbow Babies & Children’s Hospital. Helsingborg Hospital. Sanford School of Medicine and University of South Dakota. German Center for Lung Research Sweden, Austria, United States

Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension Read More »

A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes

Thi-Tina N. Nguyen, Caitlin V. Lewis, Daniel Colon Hidalgo, Janelle N. Posey, Mariah Jordan, Timothy E. Porfilio, Maya R. Grayck, Clyde J. Wright, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Frontiers in PhysiologyFront Physiol 2025; 16: DOI: 10.3389/fphys.2025.1513703 AbstractExtremely preterm birth predisposes infants to bronchopulmonary dysplasia and associated pulmonary hypertension (PH).

A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes Read More »

Sodium nitrite prevents impaired postnatal alveolar development

Kathrine L. Daniel, Chantal Gaudet, Ali Hamraghani, Nadya Ben Fadel, Behzad Yeganeh, Robert P. JankovChildren’s Hospital of Eastern Ontario Research Institute. University of Ottawa.Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00324.2024 AbstractDeficient nitric oxide (NO) signaling plays a critical role in the pathogenesis of bronchopulmonary

Sodium nitrite prevents impaired postnatal alveolar development Read More »

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