Pulmonary Vascular Pathology

Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression

Shawyon P. Shirazi, Nicholas M. Negretti, Christopher S. Jetter, Alexandria L. Sharkey, Shriya Garg, Meghan E. Kapp, Devan Wilkins, Gabrielle Fortier, Saahithi Mallapragada, Nicholas E. Banovich, Laurie C. Eldredge, Gail H. Deutsch, Christopher V. E. Wright, David B. Frank, Jonathan A. Kropski, Jennifer M. S. SucreVanderbilt University Medical Center and Vanderbilt University. Translational Genomics Research […]

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Lethal Neonatal Pulmonary Hypertension in Trisomy 21 (T21) Likely Due to Congenital Portosystemic Shunts

Rachel Guest, Dilshad Dhaliwal, Darryl Kinnear, Debra Kearney, Nahir Cortes-Santiago, Nidhy Varghese, Kalyani R. PatelBaylor College of Medicine and Texas Children’s Hospital.United States Pediatric and Developmental PathologyPediatr Devel Pathol 2025; DOI: 10.1177/10935266251343287 AbstractChildren with Trisomy 21 (T21) have an increased incidence of pulmonary hypertension (PHTN); most commonly due to congenital heart/lung diseases but also in conjunction

Lethal Neonatal Pulmonary Hypertension in Trisomy 21 (T21) Likely Due to Congenital Portosystemic Shunts Read More »

Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

Bin Liu, Dan Yi, Shuai Li, Karina Ramirez, Xiaomei Xia, Yanhong Cao, Hanqiu Zhao, Ankit Tripathi, Shenfeng Qiu, Mrinalini Kala, Ruslan Rafikov, Haiwei Gu, Vinicio de jesus Perez, Sarah-Eve Lemay, Christopher C. Glembotski, Kenneth S. Knox, Sebastien Bonnet, Vladimir V. Kalinichenko, You-Yang Zhao, Michael B. Fallon, Olivier Boucherat, Zhiyu DaiCollege of Medicine-Phoenix and University of Arizona. Washington University School of Medicine in St. Louis. Guangzhou Medical University. Indiana University College of Medicine. Arizona State University. Stanford University. Laval University. Phoenix Children’s Hospital. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.United

Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension Read More »

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3

Bum-Yong Kang, Jiwoong Choi, Victor Tseng, Yutong Zhao, Jing Zhao, Robert S. Stearman, Wilbur A. Lam, Viranuj Sueblinvong, Benjamin T. Kopp, Michael J. Passineau, Changwon Park, John Lister, Raymond J. Benza, Andrew J. JangEmory University School of Medicine. Atlanta Veterans Healthcare System. University of Kansas School of Medicine and University of Kansas. Ansible Health. Ohio

USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3 Read More »

Pulmonary artery-targeted low-dose metformin-loaded nanocapsules safely improve pulmonary arterial hypertension in rats

Ayako Chida-Nagai, Naoki Masaki, Hiroki Sato, Tatsuya Kato, Emi Takakuwa, Yoshihiro Matsuno, Atsushi Manabe, Atsuhito TakedaHokkaido University Hospital. Tokyo Women’s Medical University. Tohoku University Graduate School of Medicine. Oita University and Oita University Hospital.Japan Frontiers in PediatricsFront Pediatr 2025; 16: DOI: 10.3389/fphar.2025.1577570 AbstractIntroduction: Pulmonary arterial hypertension (PAH) remains a challenge to tackle despite various available medications. Metformin,

Pulmonary artery-targeted low-dose metformin-loaded nanocapsules safely improve pulmonary arterial hypertension in rats Read More »

MHCIIhiLYVE1loCCR2hi Interstitial Macrophages Promote Medial Fibrosis in Pulmonary Arterioles and Contribute to Pulmonary Hypertension

Fan Qiu, Hao-Ran Miao, Hong-Liang Hui, Lin-Jie Qiu, Yi Chen, Min Luo, Jian-Chao Zhang, Yan-Gui Lin, Dan Li, Sang-Bing Ong, Xue-Fei Hu, Bo Jiang, Yi-Qian ZhangEighth Affiliated Hospital of Sun Yat-sen University. Chinese University of Hong Kong. Hong Kong Children’s Hospital. China and Hong Kong Circulation ResearchCirc Res 2025; DOI: 10.1161/CIRCRESAHA.125.326173 AbstractBackground: Pulmonary hypertension (PH) is a

MHCIIhiLYVE1loCCR2hi Interstitial Macrophages Promote Medial Fibrosis in Pulmonary Arterioles and Contribute to Pulmonary Hypertension Read More »

Cyclopamine Attenuates Pulmonary Arterial Hypertension Development: Implications of Hedgehog Signaling Involvement for the Pathophysiology

Makito Sakurai, Susumu Hosakawa, Yohei Yamaguchi, Susumu Kirimura, Kensuke Ihara, Kenichi Ohashi, Tetsushi Furukawa, Tetsuo Sasano, Kenichi Kashimada, Taku IshiiInstitute of Science Tokyo. Japanese Red Cross Musashino Hospital.  National Center for Child Health and Development. Japan Federation of American Societies for Experimental Biology JournalFASEB J 2025; 39: DOI: 10.1096/fj.202403350R AbstractPulmonary arterial hypertension (PAH) is one of

Cyclopamine Attenuates Pulmonary Arterial Hypertension Development: Implications of Hedgehog Signaling Involvement for the Pathophysiology Read More »

Pulmonary arteriole narrowing in end-stage cystic fibrosis lungs occurs with and without small airway disease

Astrid Vermaut, Gitte Aerts, Lynn Willems, Vincent Geudens, Charlotte Hooft, Pieterjan Kerckhof, Lise Vanvuchelen, Marta Zapata-Ortega, Hanne Beeckmans, Xin Jin, Yousry Mohamady, Jan Van Slambrouck, Lucia Aversa, Janne Verhaegen, Emanuela E. Cortesi, Charlotte De Fays, Birgit Weynand,Dirk E. Van Raemdonck, Laurens J. Ceulemans, Wim A. Wuyts, Marianne Carlon, Robin Vos, Natalie Lorent, Ghislaine Gayan-Ramirez, Laurent

Pulmonary arteriole narrowing in end-stage cystic fibrosis lungs occurs with and without small airway disease Read More »

Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice

Yi Jin, Bernadette Chen, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00202.2024 AbstractBronchopulmonary dysplasia (BPD) is a common chronic lung disease in pediatrics. Neonatal mice placed in hyperoxia (85% oxygen, HYP) develop lung injury

Deficiency of arginase2 attenuates hyperoxia-induced inflammation and airway hyperreactivity in neonatal mice Read More »

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. NozikUniversity of Colorado, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of Nebraska Medical Center.United States American Journal of

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia Read More »

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