Pulmonary Vascular Pathology

Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats

Guoliang Wang, Jie Liu, Peiyi Bai, Hong Jiao, Xiaohui Kong, Zhangke Guo, Gaopeng Li, Aijun LiuBeijing Children’s Hospital, Beijing Pediatric Research Institute, Capital Medical University and National Center for Children’s Health. Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences and Tongji Shanxi Hospital. General Hospital of Taiyuan Iron and

Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats Read More »

Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning

Cristina Almagro-Pérez, Niccolò Peruzzi, Csaba Galambos, Andrew H.Song, Hans Brunnström, KingaI. Gawlik, MarcoStampanoni, Karin Tran-Lundmark, Goran LovricPaul Scherrer Institut. Institute for Biomedical Engineering. Lund University and Skåne University Hospital Lund. University of Colorado Anschutz Medical Campus School of Medicine. University of Texas MD Anderson Cancer Center. Switzerland, Sweden and United States Journal of the Royal

Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning Read More »

KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension

Rehab Alharbi, Merve Keles, Nadia Fernandes, Hannah Maude, Adam Fellows, Richard D. Williams, Chien-Nien Chen, Nathalie Lambie, Nik Matthews, May Al-Sahaf, Sam N. Barnett, Minzhe Guo, Lan Zhao, Allan Lawrie, Jeffrey A. Whitsett, Inês Cebola, Beata Wojciak-StothardImperial College London. University of Hafr Al Batin. Hammersmith Hospital. Cincinnati Children’s Hospital Medical Center and University of Cincinnati

KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension Read More »

Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in Down syndrome

Janelle N. Posey, Mariah Jordan, Amanda Olsen-Dufour, Thi-Tina N. Nguyen, Christine Farrell, Caitlin V. Lewis, Jamie L. Archambault, Christina Sul, Daniel Colon-Hidalgo, Eva S. Nozik, Joaquin M. Espinosa, Kelly D. Sullivan, Cassidy DelaneyUniversity of Colorado Anschutz. United States Frontiers in ImmunologyFront Immunol 2026; DOI: 10.3389/fimmu.2026.1832057 AbstractTrisomy 21 (T21) results in Down syndrome (DS), a condition associated

Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in Down syndrome Read More »

Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension

M. Elizabeth Moss, Timothy Klouda, Yan Li, Yu Liu, Meng Tan, Yunhye Kim, Yuan Hao, Mark R. Nicolls, Joseph C. Wu, Richard Bucala, Hong Chen, Eungjoo Lee, Karin Tran-Lundmark, Benjamin Raby, Ke YuanBoston Children’s Hospital and Harvard Medical School. Stanford University. University of California, San Diego. Yale School of Medicine. University of Arizona. Lund University

Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension Read More »

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension

Yong‐Jian Zhu, Jie‐Jian Kou, Ya‐Cong Bo, Meng‐Jie Zhang, Xin Fan, Lu‐Ling Zhao, Yi Yan, Hong Da Zhang, Wen‐Hui Wu, Ping Yuan, Yan Liu, Jun‐Zhuo Shi, Xiao‐Bin Pang, Yang‐Yang HeFirst Affiliated Hospital of Zhengzhou University. Huaihe Hospital and Henan University. Zhengzhou University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Fuwai Hospital and Peking Union Medical College. Shanghai Pulmonary Hospital and School of Medicine Tongji University. China Journal of the American Heart AssociationJ Am Heart Assoc

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension Read More »

H2S Donor Therapy Reverses Established Pulmonary Arterial Hypertension and Pulmonary Vascular Structural Remodeling in Rats

Jie Zheng, Yanan Zhang, Boyang Lv, Yuanyuan Ma, Xuecong Zhong, Junbao Du, Hongfang Jin, Yaqian HuangPeking University First Hospital and Peking University.China BiomedicinesBiomedicines 2026;DOI: 10.3390/biomedicines14040760 AbstractObjectives: Downregulation of the endogenous gasotransmitter hydrogen sulfide (H2S) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). While prophylactic H2S supplementation prevents PAH initiation in different rat models, its ability

H2S Donor Therapy Reverses Established Pulmonary Arterial Hypertension and Pulmonary Vascular Structural Remodeling in Rats Read More »

Inflachromene attenuates monocrotaline-induced pulmonary arterial hypertension by suppressing the HMGB1-TLR4/RAGE-NF-κB signaling pathway

Yueru Wang, Dina Nuerlan, Bilali Paizula, Yimuran Kawulijiang, Jiyao Chen, Hong Zhu, Wentao Xiao, Zhayier Tueraili, Guoming ZhangFirst Affiliated Hospital of Xinjiang Medical University. Second Affiliated Hospital of Xinjiang Medical University. First Affiliated Hospital of Shihezi University.China International ImmunopharmacologyInt Immunopharmacol 2026; DOI: 10.1016/j.intimp.2026.116712 AbstractPulmonary arterial hypertension (PAH) is a debilitating and fatal cardiovascular disorder marked by

Inflachromene attenuates monocrotaline-induced pulmonary arterial hypertension by suppressing the HMGB1-TLR4/RAGE-NF-κB signaling pathway Read More »

Excessive Postnatal Smooth Muscle Differentiation in a Lung Specific Model of TBX4-related Pulmonary Hypertension

Lea C. Steffes, Kaylie A. Chiles, Sehar R. Masud, Aleen Rahman, Madeline Dawson, Csaba Galambos, Maya E. Kumar, Ripla AroraStanford University School of Medicine. Michigan State University. University of Colorado School of Medicine and Children’s Hospital Colorado.United States Journal of Clinical Investigation InsightsJCI Insights 2026; DOI: 10.1172/jci.insight.194251 AbstractHeterozygous TBX4 variants are the second most common genetic

Excessive Postnatal Smooth Muscle Differentiation in a Lung Specific Model of TBX4-related Pulmonary Hypertension Read More »

R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice

Daniel Colon Hidalgo, Caitlin V. Lewis, Thi‐Tina N. Nguyen, Janelle N. Posey, Samuel D. Burciaga, Nathan Dee, Christina Sul, Julie Harral, David Irwin, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70307 AbstractPulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling

R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice Read More »

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