Pulmonary Vascular Pathology

New Insights: P.I.G in Preterm Infants With Isolated PDA and Severe Pulmonary Hypertension

Nadya Ben Fadel, Elham Almoli, Joseph de Nanassy, Sally MashallyChildren’s Hospital of Eastern Ontario and University of Ottawa. Canada Case Reports in PediatricsCase Rep Pediatr 2025; DOI: 10.1155/crpe/6268296 AbstractWe present a case of a premature infant who had a persistent patent ductus arteriosus (PDA) and subsequently developed severe pulmonary hypertension (PHT) and respiratory failure. A lung […]

New Insights: P.I.G in Preterm Infants With Isolated PDA and Severe Pulmonary Hypertension Read More »

Investigation of vasoactive intestinal peptide expression and significance in a congenital diaphragmatic hernia animal model

Jiajun Chen, Huijiao Xu, Li Yang, Feifan Chen, Kunpeng Li, Bing Xu, Wenying Liu, Fang HouSichuan Provincial People’s Hospital and University of Electronic Science and Technology of China School of Medicine. China Pediatric Surgery InternationalPediatr Surg Int 2025; 42: DOI: 10.1007/s00383-025-06257-7 AbstractPurpose: To investigate vasoactive intestinal peptide (VIP) expression and distribution in fetal Sprague-Dawley (SD) rat lung

Investigation of vasoactive intestinal peptide expression and significance in a congenital diaphragmatic hernia animal model Read More »

Exploring the Impact of Platelet-Derived Growth Factor D in Pulmonary Hypertension Development

Philip Tannenberg, Karin Tran‐Lundmark, Ya‐Ting Chang, Hanna Gladh, Frank Chenfei Ning, Christian Westöö, Christian Norvik, Azra Alajbegovic, Sebastian Albinsson, Hans Brunnström, Ulf Hedin, Erika FolestadKarolinska Institutet Stockholm. Skane University Hospital and Lund University. Chang Gung Memorial Hospital.Sweden and Taiwan Pulmonary CirculationPulm Circ 2025; 22: DOI: 10.1002/pul2.70216 AbstractPulmonary arterial hypertension (PAH) is a life-threatening condition with no

Exploring the Impact of Platelet-Derived Growth Factor D in Pulmonary Hypertension Development Read More »

Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage

He Zhang, Sixie Zheng, Zheng Wang, Yingying Xiao, Yuqing Hu, Debao Li, Qing Cui, Chenxi Liu, Yiting Xue, Junhua Wu, Sijuan Sun, Lincai YeAffiliated Women and Children’s Hospital of Ningbo University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China Cell

Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage Read More »

Establishment of a neonatal rat model of sequential hyperoxic hypoxia to recapitulate clinical progression of bronchopulmonary dysplasia-associated pulmonary hypertension

Dan Wang, Siqi Hu, Jingke Cao, Haoqin Fan, Ye Ma, Fan Yang, Changgen Liu, Shanghong Tang, Zhichun Feng, Yunbin Xiao, Qiuping LiAffiliated Children’s Hospital of Xiangya School of Medicine and Central South University (Hunan Children’s Hospital). Seventh Medical Center of PLA General Hospital. Second School of Clinical Medicine and Southern Medical University. Shenzhen Baoan Women’s

Establishment of a neonatal rat model of sequential hyperoxic hypoxia to recapitulate clinical progression of bronchopulmonary dysplasia-associated pulmonary hypertension Read More »

Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension

Christine L. Farrell, Mariah Jordan, Janelle N. Posey, Kimberly R. Jordan, Aneta Gandjeva, Eva S. Nozik, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham, Cassidy A. DelaneyUniversity of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of California San Francisco.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70174 AbstractUsing lung immunohistochemistry and stereology, platelets

Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension Read More »

Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension

Shyam Thapa, Poonam Sarkar, M. Waleed Gaber, Roberto Barrios, Madhulata Chauhan, Chandrasekhar Yallampalli, Binoy ShivannaTexas Children’s Hospital and Baylor College of Medicine. Houston Methodist HospitalUnited States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00234.2025 AbstractBronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH) or BPD-PH is a lung

Adrenomedullin Overexpression Protects Mice from Experimental Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension Read More »

Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice

Luca Zazzeron, Kakeru Shimoda, Paul Lichtenegger, Elizabeth Moore, Helena Tattersfield, Alexandra K. Marenco, Jiayi Kang, Haobo Li, Eizo Marutani, Donald B. Bloch, Fumito IchinoseMassachusetts General Hospital and Harvard Medical School. United States Journal of the American Heart AssociationJ Am Heart Assoc 2025; DOI: 10.1161/JAHA.125.042608 AbstractBackground: In children born at high altitude, lung development is affected by hypoxia, which can lead to pulmonary hypertension and right ventricular failure.

Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice Read More »

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension

Agus Cahyono, Irwanto, Mahrus Abdur Rahman, Widjiati WidjiatiUniversitas Airlangga. Universitas Surabaya. Indonesia Open Veterinary JournalOpen Vet J 2025; 15: 3087-3096DOI: 10.5455/OVJ.2025.v15.i7.20 AbstractBackground: Pulmonary hypertension (PH) is a progressive and potentially fatal condition if left untreated. Currently, only sildenafil and bosentan have been approved by the Food and Drug Administration for the medical treatment of pediatric patients. The

Effects of sildenafil and metformin on endothelin-1 in the progression of pulmonary hypertension Read More »

Antenatal Sildenafil for Congenital Diaphragmatic Hernia: A Systematic Review and Bayesian Meta-Analysis of Preclinical Studies

Tamara M. Hundscheid, Ilaria Amodeo, Giacomo Cavallaro, Carlijn R. Hooijmans, František Bartoš, Eduardo VillamorMosaKids Children’s Hospital and Maastricht University Medical Center. Clínica Universidad de Navarra. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Radboud University Medical Center. University of Amsterdam.Netherlands, Spain and Italy BiomedicinesBiomed 2025; 13: DOI: 10.3390/biomedicines13092274 AbstractBackground: In congenital diaphragmatic hernia (CDH), pulmonary hypoplasia and

Antenatal Sildenafil for Congenital Diaphragmatic Hernia: A Systematic Review and Bayesian Meta-Analysis of Preclinical Studies Read More »

Scroll to Top