Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

A Study on the Molecular Mechanism of High Altitude Heart Disease in Children

Qu-Zhen Tashi, Sang-Bu Tsering, Na-Ni Zhou, Yi Zhang, Yu-Juan Huang, Jia Jia, Ting-Jun LiShigatse Peopel’s Hospital. Fujungenetics Technologies Inc. Children’s Hospital of Shanghai.China Pharmacogenomics and Personalized MedicinePharmgenomica Pers Med 2022; 15: 721-731DOI: 10.2147/PGPM.S356206 AbstractObjective: High altitude heart disease (HAHD) is a common pediatric disease in high altitude areas. It usually occurs in people who have lived for […]

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Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature

Shelby Thomas, Sathiyanarayanan Manivannan, Vidu Garg, Brenda LillyNationwide Children’s Hospital and Ohio State University.United States Journal of Vascular ResearchJ Vasc Res 2022; 59: 163-175DOI: 10.1159/000522340 AbstractPulmonary arterial hypertension (PAH) is a chronic progressive disease with significant morbidity and mortality. The disease is characterized by vascular remodeling that includes increased muscularization of distal blood vessels and vessel

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Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation

Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States Physiological ReportsPhysiol Rep 2022; DOI: 10.14814/phy2.15342 AbstractThe hallmark of pulmonary hypertension (PH) is vascular remodeling. We have previously shown that human pulmonary microvascular endothelial cells (hPMVEC) respond to hypoxia with epidermal growth factor (EGF) mediated activation of the receptor tyrosine kinase, EGF

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Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage

Andreas Damianos, Shathiyah Kulandavela, Pingping Chen, Patrick Nwajei, Sunil Batlahally, Mayank Sharma, Silvia Alvarez-Cubela, Juan Dominguez-Bendala, Ronald Zambrano, Jian Huang, Joshua M. Hare, Augusto Schmidt, Merline Benny, Nelson Claure, Karen YoungUniversity of Miami Miller School of Medicine.United States Journal of Applied PhysiologyJ Appl Physiol 2022; 133: 1031-1041DOI: 10.1152/japplphysiol.00708.2021 AbstractAdults born preterm have an increased risk of

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High altitude simulation testing in patients with congenital diaphragmatic hernia

Ashlyn E. Whitlock, Catherine A. Sheils, Jill M. Zalieckas, Gary Visner, Mary Mullen, Mollie Studley, Lindsay Lemire, Terry L. BuchmillerBoston Children’s Hospital and Harvard Medical School.United States Journal of Pediatric SurgeryJ Pediatr Surg 2022; 57: 195-198DOI: 10.1016/j.jpedsurg.2021.10.044 AbstractAim of study: Congenital Diaphragmatic Hernia (CDH) is associated with lung hypoplasia and pulmonary hypertension. Many patients receive care in

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