Potential Biomarkers Associated with Pulmonary Vascular Disease

The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes

Mohamed Ahmed, Nancy G. Casanova, Nahla Zaghloul, Akash Gupta, Marisela Rodriguez, Ian R. Robbins, Carrie L. Kempf, Xiaoguang Sun, Jin H. Song, Vivian Reyes Hernon, Saad Sammani, Sara M. Camp, Alvaro Moreira, Chaur-Dong Hsu, Joe G. N. GarciaUniversity of Arizona Health Sciences. UT Health San Antonio Long School of Medicine. United States Frontiers in PhysiologyFront […]

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Factors leading to supranormal cardiac index in pediatric pulmonary hypertension patients treated with parenteral prostanoid therapy

Kimberley G. Miles Paul J. Critser, Patrick D. Evers, Michelle Cash, Melissa Magness, Elizabeth Geers Meredith O’Neil, Zhiqian Gao, Nicholas J. Ollberding, Russel HirschCincinnati Children’s Hospital Medical Center and Cincinnati College of Medicine. Oregon Health and Sciences University. United States Pulmonary CirculationPulm Circ 2023;DOI: 10.1002/pul2.12264 AbstractParenteral prostanoid therapy (PPT) can result in supranormal cardiac index (SCI;

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Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension

Chen-Yu Jiang, Li-Wei Wu, Yi-Wei Liu, Bei Feng, Lin-Cai Ye, Xu Huang, Yang-Yang He, Yi Shen, Yi-Fan Zhu, Xing-Liang Zhou, Dai-Ji Jiang, Hai-Kun Qi, Hao Zhang, Yi YanShanghai Children’s Medical Center. Henan University. Shanghaitech University. China Frontiers in ImmunologyFront Immunol 2023; DOI: 10.3389/fimmu.2023.1153573 AbstractObjective: Inflammation is recognized as a contributor in the development of pulmonary arterial hypertension

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Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity

Juan Calderón-Colmenero, Felipe Massó, Héctor González Pacheco, Julio Sandoval, Carlos Guerrero, Jorge Cervantes Salazar, José A. García-Montes, Araceli Paéz, Gabriela I. Pereira-López, Carlos Zabal-Cerdeira, Juan Pablo SandovalInstituto Nacional de Cardiologia Ignacio Chavez. Mexico Frontiers in PediatricsFront Pediatr 2023; 11DOI: 10.3389/fped.2023.1200395 AbstractEndothelial progenitor cells and circulating endothelial cells have been proposed as useful markers of severity and

Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity Read More »

Trans-Right-Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension

Philippe Chouvarine, Jonas Geldner, Roberto Giagnorio, Ekatrina Legchenko, Harald Bertram, Georg HansmannHannover Medical School.Germany Pediatric Critical Care MedicinePediatr Crit Care Med 2020; 21: 340-349DOI: 10.1097/PCC.0000000000002207 AbstractObjectives: We investigated whether concentrations of circulating microRNAs differ across the hypertensive right ventricle and pulmonary circulation, and correlate with hemodynamic/echocardiographic variables in patients with pulmonary arterial hypertension versus nonpulmonary arterial hypertension

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Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia major

Azza Abdel Gawad Tantawy, Mourad Alfy Ramzy Tadros, Amira Abdel Moneam Adly, Eman Abdel Rahman Ismail, Fatma A. Ibrahim, Nanis Mohammed Salah Eldin, Mahitab Morsy Hussein, Mervat Abdalhameed Alfeky, Sarah Mohammed Ibrahim, Marwa Adel Hashem, Fatma Soliman, Elsayed EbeidAin Shams University. Military Medical Services and Military Medical Academy. National Research Center. Egypt CytokineCytokine 2023; DOI: 10.1016/j.cyto.2022.156048

Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia major Read More »

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Xin-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan, Yangzhige He, Guang-Ming Wang,Yu Dong, Ying Yang, Yi-Min Sun, Yong-Hong Ren, Qiu-Yan Zhao, Xiao-Dan Yang, Li-Ying Wang, Cai-Jun Fu, Miao He, Si-Jin Zhang, Ji-Fen Fu, Hong Liu, Zhi-Cheng JingThe First Affiliated Hospital of Dali University. Henan University. The Affiliated Hospital of Guizhou Medical University. Yulong

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype Read More »

Congenital Diaphragmatic Hernia: Perinatal Prognostic Factors and Short-Term Outcomes in a Single-Center Series

Camilla Pagliara, Elisa Zambaiti, Giulia Brooks, Luca Bonadies, Costanza Tognon, Sabrina Salvadori, Alberto Sgrò, Francesco Fascetti LeonUniversitary Hospital of Padova. Paediatric Hospital of Torino.Italy ChildrenChildren 2023; 10: DOI: 10.3390/children10020315 AbstractBackground: Many prognostic factors for CDH patients are described and validated in the current literature: the size of diaphragmatic defects, need for patch repair, pulmonary hypertension and

Congenital Diaphragmatic Hernia: Perinatal Prognostic Factors and Short-Term Outcomes in a Single-Center Series Read More »

Identification of potential serum biomarkers for congenital heart disease children with pulmonary arterial hypertension by metabonomics

Nan Jin, Mengjie Yu, Xiaoyue Du2, Zhiguo Wu, Changlin Zhai, Haihua Pan, Jinping Gu, Baogang XieZhejiang University of Technology. Medical College of Jiaxing University. The Second Affiliated Hospital of Nanchang University. China BioMed Central Cardiovascular DisordersBMC Cardiovasc Dis 2023; 23: DOI: 10.1186/s12872-023-03171-5 AbstractBackground: Pulmonary arterial hypertension is a common complication in patients with congenital heart disease. In

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Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity

Mona Alotaibi, Junzhe Shao, Michael W. Pauciulo, William C. Nichols, Anna R. Hemnes, Atul Malhotra, Nick H. Kim, Jason X-J Yuan, Timothy Fernandes, Kim M. Kerr, Laith Alshawabkeh, Ankit A. Desai, Andreea M. Bujor, Robert Lafyatis, Jeramie D. Waltrous, Tao Long, Susan Cheng, Stephen Y. Chan, Mihit Jain University of California San Diego. Peking University.

Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity Read More »

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