Potential Biomarkers Associated with Pulmonary Vascular Disease

MicroRNA Profiling to Inform Disease Classification, Severity, and Treatment Response in Pediatric Pulmonary Hypertension

Michael A. Smith, Sam Chiacchia, Jason Boehme, Sanjeev A. Datar, Emily Morell, Roberta L. Keller, Amy Romer, Elizabeth Colglazier, Clair Parker, Jasmine Becerra, Jeffrey R. FinemanUniversity of California, San Francisco. Stanford University. Children’s Hospital of Philadelphia.United States American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2024; DOI: https://doi.org/10.1152/ajpheart.00622.2024 AbstractPediatric pulmonary […]

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Longitudinal evaluation of hemodynamic blood and echocardiographic biomarkers for the prediction of BPD and BPD-related pulmonary hypertension in very-low-birth-weight preterm infants

Lukas Schroeder, Fabian Ebach, Tamene Melaku, Brigitte Strizek, Jorge Jimenez‑Cruz, Ramona Dolscheid‑Pommerich, Andreas Mueller, Florian KipfmuellerUniversity Children’s Hospital Bonn and University Hospital Bonn.Germany European Journal of PediatricsEur J Pediatr 2024; 184: DOI: 10.1007/s00431-024-05841-8 AbstractVery-low-birth-weight infants (VLBW, < 1500 g) are at risk of developing bronchopulmonary dysplasia (BPD) and are at risk for BPD-related pulmonary hypertension (PH). The longitudinal measurement of innovative blood and echocardiographic

Longitudinal evaluation of hemodynamic blood and echocardiographic biomarkers for the prediction of BPD and BPD-related pulmonary hypertension in very-low-birth-weight preterm infants Read More »

microRNAs in Congenital Diaphragmatic Hernia: Insights into Prenatal and Perinatal Biomarkers and Altered Molecular Pathways: microRNAs in Congenital Diaphragmatic Hernia for Pathway Analysis and Prognostic Biomarkers

James R. Bardill, Anis Karimpour-Fard, Courtney C. Breckenfelder, Carmen C. Sucharov, Caitlin R. Eason, Lauren T. Gallagher, Ludmila Khailova, Clyde J. Wright, Jason Gien, Henry L. Galan, S. Christopher DerderianUniversity of Colorado School of Medicine and Children’s Hospital Colorado. United States American Journal of Obstetrics and Gynecology Maternal and Fetal MedicineAm J Obstet Gynecol MFM

microRNAs in Congenital Diaphragmatic Hernia: Insights into Prenatal and Perinatal Biomarkers and Altered Molecular Pathways: microRNAs in Congenital Diaphragmatic Hernia for Pathway Analysis and Prognostic Biomarkers Read More »

Utility of Serum Matrix Metalloproteinase-7 as a Biomarker in Cholestatic Infants with Congenital Heart Disease

Sindhu Pandurangi, Michael E. Kim, Nicolas Noriega, Bradley Conant, JangDong Seo, Reena Mourya, Pranavkumar Shivakumar, Anna L. Peters, Andrew Misfeldt, Meghan Chlebowski Children’s Medical Center of Dallas and University of Texas Southwestern Medical Center. Hospital for Sick Children. University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center. United States Pediatric CardiologyPediatr Cardiol

Utility of Serum Matrix Metalloproteinase-7 as a Biomarker in Cholestatic Infants with Congenital Heart Disease Read More »

Utility of urinary NT-proBNP in congenital diaphragmatic hernia: a prospective pilot study

Srirupa Hari Gopal, Kelly Frances Martinek, Candice Vacher, Judith Becker, Nighy P. Varghese, Betul Yilmaz Furtun, Joseph L. Hagan, Sharada H. Gowda, Mohan Pammi, Sridevi Devaraj, Caraciolo J. FernandesBaylor College of Medicine.United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03600-x AbstractBackground: Echocardiography is the reference standard for diagnosing pulmonary hypertension (PH) and cardiac dysfunction (CD) in congenital diaphragmatic

Utility of urinary NT-proBNP in congenital diaphragmatic hernia: a prospective pilot study Read More »

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha TalatiVanderbilt University Medical Center and Vanderbilt University.United States Frontiers in MedicineFront Med 2024; DOI: 10.3389/fmed.2024.1387195 AbstractBackground: In PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma Read More »

Variation and significance of serum microRNA-21 level in pediatric pulmonary artery hypertension associated with congenital heart disease

Yanming Shen, Dongshan Liao, Wenlin Shangguan, Liangwan ChenFujian Medical University. Union Hospital. Fuzhou Changle District People’s Hospital.China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2024; DOI: 10.3389/fcvm.2024.1424679 AbstractObjective: This study strives to the variation and significance of microRNA-21 (miR-21) in children with congenital heart disease (CHD)-related pulmonary artery hypertension (PAH).Methods: Children with CHD (n = 179) were selected as subjects,

Variation and significance of serum microRNA-21 level in pediatric pulmonary artery hypertension associated with congenital heart disease Read More »

Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH)

Eva Petrow, Changyong Feng, Ashley Frazer-Abel, Roberta Goncalves Marangoni, Katie Lutz, William C. Nichols, V. Michael Holers, Christopher Ritchlin, R. James White III, Benjamin D. KormanUniversity of Rochester Medical Center. University of Colorado School of Medicine. Cincinnati Children’s Medical Center and University of Cincinnati College of Medicine. United States Seminars in Arthritis and RheumatismSemin Arthritis

Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) Read More »

Inhibition of DLL4/Notch Signaling Pathway Promotes M2 Polarization and Cell Proliferation in Pulmonary Arterial Hypertension

Guangxing Tan, Chenxia Juan, Yan Mao, Gang Xue, Zhuyuan FangJiangsu Province Hospital of Chinese Medicine, Wuxi Hospital of Traditional Chinese Medicine and Affiliated Hospital of Nanjing University of Chinese Medicine. Yangzhou Hospital of Traditional Chinese Medicine. China American Chemical Society OmegaACS Omega 2024; 9: 37923-37933DOI: 10.1021/acsomega.4c04307 AbstractIn this study, we conducted a comprehensive analysis to identify

Inhibition of DLL4/Notch Signaling Pathway Promotes M2 Polarization and Cell Proliferation in Pulmonary Arterial Hypertension Read More »

Circulating Endothelin 1 but Not Transforming Growth Factor-β Levels Are Reduced after Pulmonary Endarterectomy in Subjects Affected by Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study

Pasquale Totaro, Claudio Tirelli, Lucia Sacchi, Annalisa De Silvestri, Mara DeAmici, Fabrizio Grosjean, Giorgia Testa, Alessia Alloni, Eraldo Kushta, Riccardo Albertini, Teresa Rampino, Andrea Maria D’ArminiFoundation I.R.C.C.S. Policlinico San Matteo. University of Milan. University of Pavia. Italy Journal of Clinical MedicineJ Clin Med 2024; DOI: 10.3390/jcm13174977 AbstractBackground and objectives: Endothelin-1 (ET-1) and transforming growth factor-β (TGF-β) play

Circulating Endothelin 1 but Not Transforming Growth Factor-β Levels Are Reduced after Pulmonary Endarterectomy in Subjects Affected by Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study Read More »

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