Potential Biomarkers Associated with Pulmonary Vascular Disease

A circulating MicroRNA signature for the diagnosis of pulmonary arterial hypertension and functional characterization of candidate miR-3168

Mauro Lago-Docampo, Ainhoa Iglesias-López, Carlos Vilariño, Adolfo Baloira, Joan Albert Barberá, Isabel Blanco, Diana ValverdeUniversidade de Vigo. Galicia Sur Health Research Institute. Hospital Povisa. Complejo Hospitalario Universitario de Pontevedra. University of Barcelona. Stanford University School of Medicine.Spain and United States Scientific ReportsSci Rep 2026; DOI: 10.1038/s41598-026-42550-8 AbstractPulmonary Arterial Hypertension (PAH) is a rare, progressive disorder characterized […]

A circulating MicroRNA signature for the diagnosis of pulmonary arterial hypertension and functional characterization of candidate miR-3168 Read More »

Association Between Hemodynamic Parameters and Gut Microbiota in Fontan Circulation: A Cross-Sectional Study

Saviga Sethasathien, Chanon Kunasol, Suchaya Silvilairat, Rekwan Sittiwangkul, Pannipa Suwannasom, Nipon Chattipakorn, Krit Leemasawat, Siriporn C. ChattipakornChiang Mai University. Thailand Journal of the American Heart AssociationJ Am Heart Assoc 2026; DOI: 10.1161/JAHA.125.045962 AbstractBackground: The Fontan operation results in chronic hemodynamic alterations, including central venous hypertension, which may contribute to gut dysbiosis. This study aimed to compare gut

Association Between Hemodynamic Parameters and Gut Microbiota in Fontan Circulation: A Cross-Sectional Study Read More »

A Novel Rat Model for Group 2 Pulmonary Hypertension by Total Pulmonary Vein Banding: Multi-Omics Insights into Pathophysiological Mechanisms

Jin Shentu, Wenxuan Dai, Chang Chen, Jiawei Huang, Lijun Chen, Yi Yan, Han Zhang, Zhongqun Zhu, Guocheng Shi, Huiwen ChenShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. China Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2026; DOI: 10.1016/j.jtcvs.2026.01.017 AbstractObjectives: Group 2 pulmonary hypertension (PH) remains a highly morbid disease, yet no

A Novel Rat Model for Group 2 Pulmonary Hypertension by Total Pulmonary Vein Banding: Multi-Omics Insights into Pathophysiological Mechanisms Read More »

Microbiome-Metabolome Axis in BALF Reveals Novel Diagnostic Biomarkers for Congenital Heart Disease-Associated Pulmonary Arterial Hypertension

Xiaoyu Zhang, Liming Cheng, Yuan Zhou, Jiahui Xie, Wenting Gui, Jiaxiang Chen, Zidan Zhang, Kai Liu, Runwei MaFuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated Cardiovascular Hospital of Kunming Medical University. Kunming Children’s Hospital.China Journal of Cardiovascular Development and DiseaseJ Cardiovasc Dev Dis 2026; 13: DOI: 10.3390/jcdd13010032 AbstractBackground: Early identification of irreversible pulmonary vascular remodeling in

Microbiome-Metabolome Axis in BALF Reveals Novel Diagnostic Biomarkers for Congenital Heart Disease-Associated Pulmonary Arterial Hypertension Read More »

Mean corpuscular haemoglobin concentration (MCHC): a new biomarker for high-altitude pulmonary edema in the Ecuadorian Andes

Karen Sánchez, Lenin Ramírez‑Cando, Wilfre Machado, AnitaVillafuerte, Santiago BallazYachay University for Experimental Technology and Research. Hospital Claudio Benati. Universidad Espíritu Santo.Ecuador Scientific ReportsSci Rep 2022; 12: DOI: 10.1038/s41598-022-25040-5 AbstractAscent to high altitude (> 3000 m height above sea level or m.a.s.l) exposes people to hypobaric atmospheric pressure and hypoxemia, which provokes mountain sickness and whose symptoms

Mean corpuscular haemoglobin concentration (MCHC): a new biomarker for high-altitude pulmonary edema in the Ecuadorian Andes Read More »

Pulmonary hypertension in pediatric patients with cystic fibrosis during acute pulmonary exacerbations: prevalence and associated factors

Zahra Roshanzamir, Fatemeh Mohammadi, Rohola ShirzadiNamazi Hospital and Shiraz University of Medical Sciences. Children’s Medical Center and Tehran University of Medical Sciences.Iran BioMedical Central Pulmonary MedicineBMC Pulm Med 2026; DOI: 10.1186/s12890-025-04095-w AbstractBackground: Cystic fibrosis (CF) is a multi-organ disorder in which respiratory complications account for the majority of its cause of mortality. This study aimed to investigate

Pulmonary hypertension in pediatric patients with cystic fibrosis during acute pulmonary exacerbations: prevalence and associated factors Read More »

Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets

MengzeWang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie DingKunming Children’s Hospital. Southern Medical University. Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Taizhou Central Hospital (Taizhou University Hospital). Second Hospital of Jiaxing and Second Affiliated Hospital of Jiaxing University. Zhejiang Rongjun Hospital.

Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets Read More »

Increased hepcidin levels in high-altitude pulmonary edema

Sandro Altamura, Peter Bärtsch, Christoph Dehnert, Marco Maggiorini, Günter Weiss, Igor Theurl, Martina U. Muckenthaler, Heimo MairbäurlUniversity Hospital Heidelberg. University Hospital Zürich. Medical University of Innsbruck. Germany, Switzerland and Austria Journal of Applied PhysiologyJ App Physiol 2015; 118: 292-298 DOI: 10.1152/japplphysiol.00940.2014 AbstractLow iron availability enhances hypoxic pulmonary vasoconstriction (HPV). Considering that reduced serum iron is caused

Increased hepcidin levels in high-altitude pulmonary edema Read More »

Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study

Kevin R. Barker, Andrea L. Conroy, Michael Hawkes, Holly Murphy, Prativa Pandey, Kevin C. KainUniversity of Toronto and University Health Network-Toronto General Hospital. University of Alberta. CIWEC Hospital and Travel Medicine Center. Canada and Nepal Journal of Travel MedicineJ Travel Med 2016; 23: DOI: 10.1093/jtm/taw005 AbstractBackground: The mechanisms underlying acute mountain sickness (AMS) and high-altitude pulmonary edema

Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study Read More »

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway

Zongbin Li, Miao Zhao, Shanshan Ma, Shuyu LeiThird People’s Hospital of Xinjiang Uygur Autonomous Region. China European Journal of Medical ResearchEur J Med Res 2025; DOI: 10.1186/s40001-025-03586-0 AbstractBackground: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) drives lethal pulmonary vascular remodeling. While circular RNAs (circRNAs) are emerging as disease regulators, their functional roles in PAH-CHD remain

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway Read More »

Scroll to Top