Pediatric Pulmonary Vascular Disease

Fetal therapies in congenital diaphragmatic hernia: a review of possibilities and practical challenges

Adriana Dekirmendjian, Fabian Doktor, Lina Antounians, Augusto ZaniUniversity of Toronto and Hospital for Sick Children. St. Louis Children’s Hospital and Washington University. Canada and United States Seminars in Fetal and Neonatal MedicineSemin Fetal Neonatal Med 2025; DOI: 10.1016/j.siny.2025.101656 AbstractCongenital diaphragmatic hernia (CDH) is characterized by pulmonary hypoplasia. CDH lungs exhibit an inflammatory signature with impaired growth, […]

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A comparative analysis of clinical phenotypes and outcomes in childhood interstitial lung disease due to surfactant dysfunction disorders: focusing on mutations in SFTPC, ABCA3, and NKX2-1 genes

Xiaolei Tang1 , Shunying Zhao, Yuelin Shen1, Yu Tang, Xingfeng Yao, Hui Xu, Hui Liu, Xiaoyan Zhang, Xiao Li, Yanqiong Wang, Haiming YangBeijing Children’s Hospital, National Center for Children’s Health and Capital Medical University. Henan Children’s Hospital, Zhengzhou Children’s Hospital and Children’s Hospital Affiliated to Zhengzhou University. Children’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang

A comparative analysis of clinical phenotypes and outcomes in childhood interstitial lung disease due to surfactant dysfunction disorders: focusing on mutations in SFTPC, ABCA3, and NKX2-1 genes Read More »

Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia

Kel Vin Woo, Philip T. Levy, Carla J. Weinheimer, Amanda L. Hauck, Aaron Hamvas, David M. Ornitz, Attila Kovacs, Gautam K. SinghWashington University School of Medicine. Boston Children’s Hospital, Department of Pediatrics and Harvard Medical School. Ann and Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. Children’s Hospital Michigan

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Risk Factors and Predictors of Mechanical Ventilation in Neonates With Meconium Aspiration Syndrome: A Retrospective Study at King Salman Armed Forces Hospital, Tabuk, Saudi Arabia

Abdulaziz A. Bedaiwi, Muhanned Amawi, Wegdan MawlanaKing Salman Armed Forces Hospital.Saudi Arabia CureusCureus 2025; 17: DOI: 10.7759/cureus.88486 AbstractBackground: Meconium aspiration syndrome (MAS) is a critical neonatal condition predominantly associated with term and post-term pregnancies, characterized by the aspiration of meconium-stained amniotic fluid (MSAF) leading to severe respiratory distress. Despite advances in obstetric and neonatal care, MAS

Risk Factors and Predictors of Mechanical Ventilation in Neonates With Meconium Aspiration Syndrome: A Retrospective Study at King Salman Armed Forces Hospital, Tabuk, Saudi Arabia Read More »

Revived role of reverse Potts shunt in management of paediatric severe pulmonary hypertension

Zhangwei Wang, Honghao Fu, Shoujun LiChinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases and Fuwai Hospital.China Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125101352 AbstractPulmonary artery hypertension in children is a progressive, fatal disease secondary to a variety of causes leading to right ventricular dysfunction. Traditional treatments include lung

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Tracheostomy and Chronic Ventilator Dependence After Congenital Diaphragmatic Hernia Repair: Long-Term Outcomes

Sarah D. King, Keerthi Burgi, Erin E. Perrone, George B. Mychaliska, Amy G. Filbrun, Joseph T. ChurchUniversity of Michigan and University of Michigan Medical School. United States Journal of Surgical ResearchJ Surg Res 2025; 314: 567-573DOI: 10.1016/j.jss.2025.07.052 AbstractIntroduction: There are limited data regarding long-term outcomes in patients with congenital diaphragmatic hernia (CDH) who require tracheostomy with chronic

Tracheostomy and Chronic Ventilator Dependence After Congenital Diaphragmatic Hernia Repair: Long-Term Outcomes Read More »

Decreased smooth muscle cells and fibrous thickening of the tunica media in peripheral pulmonary artery stenosis in Alagille syndrome

Yosuke Ogawa, Amane Yamamoto, Sho Yamazawa, Masako Ikemura, Yasutaka Hirata, Ryo InuzukaUniversity of Tokyo Hospital.Japan Cardiovascular PathologyCardiovasc Pathol 2025; DOI: 10.1016/j.carpath.2024.107677 AbstractAlagille syndrome is caused by mutations in genes involved in NOTCH signaling, specifically JAG1 and NOTCH2, and is associated with a high rate of peripheral pulmonary artery stenosis. In this study, we report the case

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Chronic cyanosis since infancy: Unveiling a giant right pulmonary arteriovenous malformation

Dian Komalaa, Harry Galuh Nugrahaa, Firman Ramadhana, Rais Khairuddina, Rahmat Budi Kuswiyantob, Putria Rayani ApandiUniversitas Padjadjaran.Indonesia Radiology Case ReportsRadiol Case Rep 2025; 20: 5353-5356DOI: 10.1016/j.radcr.2025.06.084 AbstractGiant pulmonary arteriovenous malformations (PAVMs) are rare vascular anomalies involving direct connections between pulmonary arteries and veins, leading to right-to-left shunting and systemic hypoxemia. While small PAVMs may be asymptomatic, larger

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Early postnatal right-to-left patent ductus arteriosus shunting and severe outcomes in neonates with congenital diaphragmatic hernia: a retrospective cohort study

Jung Il Kwak, Juhee Park, Mi Jin Kim, Kyusang Yoo, Bo Kyeong Jin, Tae-Gyeong Kim, Joo Hyung Roh, Ha Na Lee, Keon Hee Seol, Chae Young Kim, Soo Hyun Kim, Jiyoon Jeong, Byong Sop Lee, Euiseok JungAsan Medical Center Children’s Hospital and University of Ulsan College of Medicine. BioMedical Central PediatricsBMC Pediatr 2025; 25: DOI: 10.1186/s12887-025-05986-x

Early postnatal right-to-left patent ductus arteriosus shunting and severe outcomes in neonates with congenital diaphragmatic hernia: a retrospective cohort study Read More »

General and Emergency Presentations of Children with Congenital Heart Defect and Factors Affecting it as Seen in A Tertiary Health Institution in Enugu

I. O. Arodiwe, I. A. Nwafor, F. A. Ujunwa, B. O. Edulu, J. M. Chinawa, T. A. Oguonu, N. Ezemba, J. C. EzeUniversity of Nigeria, Enugu Campus.Nigeria West Africa Journal of MedicineWest Africa J Med 2025; 42: 202-207DOI: Not Available AbstractBackground and objectives: The pattern of emergency presentations in children with congenital heart disease (CHD) is

General and Emergency Presentations of Children with Congenital Heart Defect and Factors Affecting it as Seen in A Tertiary Health Institution in Enugu Read More »

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