Pediatric Pulmonary Vascular Disease

Procedural Variation May Contribute to 6-Minute Walk Distance Variability in Real-World Pediatric Pulmonary Arterial Hypertension Study

Cynthia Kleppinger, Dunbar Ivy, Norman Stockbridge, Angela Bates, Stephanie Handler, Usha S. Krishnan, Mary P. Mullen, Delphine Yung, Rachel K. Hopper, Nidhy P. Varghese, Jef Fineman, Eric D. Austin, Catherine M. Avitabile, Grace Freire, Jennifer Clark, Haihao SunUnited States Food and Drug Administration. University of Colorado. Stollery Children’s Hospital. Medical College of Wisconsin. Columbia University […]

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Echo-Derived Right Ventricular Strain Identifies Pulmonary Hypertension in Pediatric Ventricular Assist Device Patients

Ryan S. Bishop, Tam T. Doan, Claudia Lara, Lindsay F. Eilers, Hari P. Tunuguntla, Joseph A. Spinner, Ricardo H. Pignatelli, Anitha Parthiban, James C. WilkinsonTexas Children’s Hospital and Baylor College of Medicine.United States American Society for Artificial Internal OrgansASAIO 2025; DOI: 10.1097/MAT.0000000000002489 AbstractIdentifying pulmonary hypertension in pediatric patients with continuous-flow ventricular assist device (cf-VAD) remains challenging,

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Anxiety and Depression Screening of Youth in Pediatric Pulmonary Hypertension Clinic: A Multi-Center, Cross-Sectional Study

Claire Parker, Elise Whalen, Michael A. Smith, Jasmine Becerra, Leah Stevens, Catherine M. Avitabile, Anna Brown, Michelle Cash, Emma Olson Jackson, Julia McSweeney, Kathleen Miller‐Reed, Janette T. Reyes, Cathy Sheppard, Mary P. Mullen, Pulmonary Hypertension Network (PPHNet)University of California, San Francisco and Benioff Children’s Hospital. Texas Children’s Hospital. University of Pennsylvania Perelman School of Medicine

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The Use of Vasodilator Therapy in Fontan Patients: A Single-Centre Experience

Alessia Faccini, Martina Avesani, Roberta Biffanti, Elettra Pomiato, Domenico Sirico, Alice Pozza, Alessia Cerutti, Elena Reffo, Biagio Castaldi, Giovanni Di SalvoUniversity Hospital Padua.Italy ChildrenChildren 2025; 12:DOI: 10.3390/children12060751 AbstractBackground: The aim of this study was to describe our centre experience in the use of pulmonary vasodilator therapy in Fontan patients.Methods: We retrospectively enrolled patients that underwent Fontan operation between

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Revisiting Inhaled Nitric Oxide Utilization in Congenital Diaphragmatic Hernia: A National Cohort Study of Major Children’s Hospitals in the United States

Anne M. Sescleifer, Charbel Chidiac, Zane J. Hellmann, Katherine M. McDermott, Alejandro V. Garcia, Daniel S. Rhee, Mark B. Slidell, Daniel G. Solomon, Shauen M. KunisakiJohns Hopkins University School of Medicine. Yale School of Medicine.United States Journal of Pediatric SurgeryJ Pediatr Surg 2025; DOI: 10.1016/j.jpedsurg.2025.162423 AbstractPurpose: For over a decade, there has been evidence suggesting a lack

Revisiting Inhaled Nitric Oxide Utilization in Congenital Diaphragmatic Hernia: A National Cohort Study of Major Children’s Hospitals in the United States Read More »

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring

Ze‑wen Chen, Yi‑fan Li, Hai‑long Qiu, Wen Xie, Tian‑yu Chen, Yong Zhang, Ji‑mei Chen, Jian Zhuang, Shu‑sheng WenGuangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) and Southern Medical University. China Current Medical ScienceCurr Med Sci 2025; DOI: 10.1007/s11596-025-00074-8 AbstractObjective: Electronic cigarettes (ECs) differ from traditional tobacco smoke but may contribute to cardiopulmonary remodeling. Pulmonary hypertension (PH),

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring Read More »

Percutaneous Balloon Mitral Valvuloplasty in Children and Adolescents With Juvenile Rheumatic Mitral Stenosis: Single Centre Experience

Abhay Pota, Tarun Parmar, Priyanka Agarwal, Bhavik Champaneri, Amit Mishra, Trushar Gajjar, Jigar Surti, Shilpa Deodhar, Amit Kungwani, Gajendra DubeyUN Mehta Institute of Cardiology and Research Centre. India CureusCureus 2025; 17: DOI: 10.7759/cureus.84707 AbstractBackground Rheumatic mitral stenosis (MS) in India is known to affect at a younger age, worsen rapidly, and have severe valvar and subvalvar

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Echocardiographic Prediction of Hemodynamics During Acute Vasoreactivity Testing in Pediatric Pulmonary Arterial Hypertension

Charles T. Simpkin, Benjamin S. Frank, Yuanqing Liu, Zhaozing Pan, D. Dunbar Ivy, Dale A. BurkettChildren’s Hospital Colorado and University of Colorado-Anschutz Medical Campus.United States EchocardiographyEchocardiography 2025; DOI: 10.1111/echo.70232 AbstractPurpose: In pediatric pulmonary arterial hypertension (PAH), echocardiography is frequently used to assess response to acute vasodilator therapy. We sought to evaluate whether echocardiography is sensitive enough to

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Pediatric Use of Inhaled Iloprost

Stephanie S. Handler, Steven H. Abman, Nidhy P. Varghese, D. Dunbar Ivy Medical College of Wisconsin and Children’s WIsconsin. University of Colorado School of Medicine and Children’s Hospital Colorado. Baylor College of Medicine and Texas Children’s Hospital.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70115 AbstractAbstract Not Available CategoryMedical Therapy. Efficacy or Lack of Efficacy Age

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Postnatally induced TBX4 insufficiency confers pulmonary hypertension and impairs lung development in infant mice

Caroline F. Smith, Kathy L. Ding, Gregory J. Seedorf, Csaba Galambos, Steven H. AbmanUniversity of Colorado School of Medicine. United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04127-5 AbstractBackground: Genetic variants in T-box transcription factor 4 (TBX4) cause pulmonary hypertension (PH); however, there are diverse phenotypes with respect to the timing and severity of disease. Previous mouse studies

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