Pediatric Pulmonary Vascular Disease

Fetal therapy for congenital diaphragmatic hernia: past, present and future

Nimrah Abbasi, Tim Van Mieghem, Greg RyanMount Sinai Hospital and University of Toronto.Canada World Journal of Pediatric SurgeryWorld J Pediatr Surg 2025;DOI: 10.1136/wjps-2024-000835 AbstractCongenital diaphragmatic hernia (CDH) affects 1/2500-5000 infants and is associated with significant neonatal morbidity and mortality related to pulmonary hypoplasia and pulmonary hypertension. Current estimates of perinatal mortality are between 30-40%. With advances […]

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Usefulness of exercise stress echocardiography in a patient with unilateral pulmonary branch stenosis

Ryohei Yokoyama, Yoshihiko Kodama, Kazunari Takamura, Masako Takahashi, Miyo Tanaka, Nozomi Watanabe, Hiroshi MoritakeUniversity of Miyazaki.Japan Journal of Cardiology CasesJ Cardiol Cases 2025; 31: 155-157DOI: 10.1016/j.jccase.2025.02.003 AbstractExercise stress echocardiography (ESE) is a feasible and valuable tool for evaluating subclinical pulmonary hypertension (PH). However, its utility in patients with unilateral pulmonary branch stenosis remains unclear. We present

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Whole exome sequencing unravels genetic architecture and its clinical implications in pediatric pulmonary arterial hypertension

Dai-Ji Jiang, Yi-Jia Yang, Yu-Zhen Wang, Xu Zhang, Wen-Xiu, Chan, Ting-Ting Yu, Hao Chen, Hao Zhang, Yi Yan, Li-Jun FuShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine.China International Journal of CardiologyInt J Cardiol 2025; DOI: 10.1016/j.ijcard.2025.133515 AbstractBackground: Pulmonary arterial hypertension (PAH) is a severe disease with significant genetic predisposition.

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Predicting pulmonary hemodynamics in pediatric pulmonary arterial hypertension using cardiac magnetic resonance imaging and machine learning: an exploratory pilot study

Hung Chu, Rosaria J. Ferreira, Chantal Lokhorst, Johannes M. Douwes, Meindina G. Haarman, Tineke P. Willems, Rolf M.F. Berger, Mark-Jan PloegstraBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen. Frisius Medical Center Leeuwarden.Netherlands International Journal of Cardiovascular ImagingInt J Cardiovasc Imaging 2025; DOI: 10.1007/s10554-025-03434-6 AbstractPurpose: Pulmonary arterial hypertension (PAH) significantly affects the pulmonary vasculature, requiring

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Severe Early-Onset Pulmonary Hypertension in a Six-Month-Old With Down Syndrome and Isolated Secundum Atrial Septal Defect

Fatima Abeer, Aasim Ayaz Wani, Bisma Javid, Aisha Mahmood, Gazala AndleebGovernment Medical College, Srinagar. National Institute of Technology Srinagar. India CureusCureus 2025; 17: DOI: 10.7759/cureus.84019 AbstractInfants with Down syndrome (trisomy 21) commonly present with congenital heart defects and immune dysregulation, significantly increasing the risk of early-onset pulmonary arterial hypertension (PAH). Although secundum atrial septal defects (ASDs)

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Oxygen Saturation Targeting in the Neonatal Intensive Care Unit

Faeq Almudares, Bheru Gandhi, Jonathan Davies, Xanthi Couroucli, Natalie Villafranco, Nidhy Paulose Varghese, Milenka Cuevas Guaman, Charleta Guillory, Binoy ShivannaBaylor College of Medicine.United States Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14113975 AbstractOxygen (O2) is vital for cellular development, function, proliferation, and repair, underscoring its critical role in organogenesis. Both hypoxia (reduced tissue O2)

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Case Report: Pulmonary arterial hypertension in children caused by a new mutation in the BMPR2 gene

Ting Tang, Shuqi Wu, Chang Peng, Li WangGuizhou Children’s Hospital and Affiliated Hospital of Zunyi Medical University.China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1572733 AbstractPulmonary arterial hypertension (PAH) is a rare and severe condition that has been linked to hereditary factors. Mutations in the gene encoding bone morphogenetic protein receptor 2 (BMPR2) have been identified

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Incidence and clinical predictors of hyper-direct bilirubinemia in preterm infants without underlying disease

Takuya Akimoto, Nobuhiko Nagano, Yuki Sato, Hidetoshi Go, Koichiro Hara, Takayuki Imaizumi, Ryoji Aoki, Midori Hijikata, Aya Okahashi, Ichiro MoriokaNihon University School of Medicine. Japan Pediatrics InternationalPediatr Int 2025; DOI: 10.1111/ped.70026 AbstractBackgrounds: This study aimed to identify the incidence and clinical predictors of hyper-direct bilirubinemia (hyper-DB) in preterm infants without underlying diseases.Methods: We enrolled neonates born at <34

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Congenital diaphragmatic hernia with congenital heart disease including ventricular septal defect: Risk factors

Yuichi Hirano, Keita Terui, Wataru Kudo, Ayako Takenouchi, Shugo Komatsu, Saroru Oita, Hiroko Yoshizawa, Takashi Fumita, Yusaku Yoshino, Tomoro HishikiChiba University Graduate School of Medicine.Japan Pediatric InternationalPediatr Int 2025; DOI: 10.1111/ped.70126 AbstractBackground: Congenital diaphragmatic hernia (CDH) with congenital heart disease (CHD) has a poor prognosis. This study aimed to establish the prognostic factors of CDH associated with

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Programmatic Approach to Outpatient Cardiac Catheterization in Children With Stable Pulmonary Arterial Hypertension

Gregory T. Adamson, Minnie N. Dasgupta, Zachary Kleiman, Lynn F. Peng, Michelle Ogawa, Vidhya Balasubramanian, Chandra Ramamoorthy, Jeffrey A. FeinsteinStanford University School of Medicine. United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70105 AbstractWhen performing cardiac catheterization in pediatric outpatients with pulmonary arterial hypertension (PH), our approach is to allow spontaneous ventilation, minimize procedural length, and

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