Pediatric Pulmonary Vascular Disease

The Use of Vasodilator Therapy in Fontan Patients: A Single-Centre Experience

Alessia Faccini, Martina Avesani, Roberta Biffanti, Elettra Pomiato, Domenico Sirico, Alice Pozza, Alessia Cerutti, Elena Reffo, Biagio Castaldi, Giovanni Di SalvoUniversity Hospital Padua.Italy ChildrenChildren 2025; 12:DOI: 10.3390/children12060751 AbstractBackground: The aim of this study was to describe our centre experience in the use of pulmonary vasodilator therapy in Fontan patients.Methods: We retrospectively enrolled patients that underwent Fontan operation between […]

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Revisiting Inhaled Nitric Oxide Utilization in Congenital Diaphragmatic Hernia: A National Cohort Study of Major Children’s Hospitals in the United States

Anne M. Sescleifer, Charbel Chidiac, Zane J. Hellmann, Katherine M. McDermott, Alejandro V. Garcia, Daniel S. Rhee, Mark B. Slidell, Daniel G. Solomon, Shauen M. KunisakiJohns Hopkins University School of Medicine. Yale School of Medicine.United States Journal of Pediatric SurgeryJ Pediatr Surg 2025; DOI: 10.1016/j.jpedsurg.2025.162423 AbstractPurpose: For over a decade, there has been evidence suggesting a lack

Revisiting Inhaled Nitric Oxide Utilization in Congenital Diaphragmatic Hernia: A National Cohort Study of Major Children’s Hospitals in the United States Read More »

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring

Ze‑wen Chen, Yi‑fan Li, Hai‑long Qiu, Wen Xie, Tian‑yu Chen, Yong Zhang, Ji‑mei Chen, Jian Zhuang, Shu‑sheng WenGuangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) and Southern Medical University. China Current Medical ScienceCurr Med Sci 2025; DOI: 10.1007/s11596-025-00074-8 AbstractObjective: Electronic cigarettes (ECs) differ from traditional tobacco smoke but may contribute to cardiopulmonary remodeling. Pulmonary hypertension (PH),

Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring Read More »

Percutaneous Balloon Mitral Valvuloplasty in Children and Adolescents With Juvenile Rheumatic Mitral Stenosis: Single Centre Experience

Abhay Pota, Tarun Parmar, Priyanka Agarwal, Bhavik Champaneri, Amit Mishra, Trushar Gajjar, Jigar Surti, Shilpa Deodhar, Amit Kungwani, Gajendra DubeyUN Mehta Institute of Cardiology and Research Centre. India CureusCureus 2025; 17: DOI: 10.7759/cureus.84707 AbstractBackground Rheumatic mitral stenosis (MS) in India is known to affect at a younger age, worsen rapidly, and have severe valvar and subvalvar

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Echocardiographic Prediction of Hemodynamics During Acute Vasoreactivity Testing in Pediatric Pulmonary Arterial Hypertension

Charles T. Simpkin, Benjamin S. Frank, Yuanqing Liu, Zhaozing Pan, D. Dunbar Ivy, Dale A. BurkettChildren’s Hospital Colorado and University of Colorado-Anschutz Medical Campus.United States EchocardiographyEchocardiography 2025; DOI: 10.1111/echo.70232 AbstractPurpose: In pediatric pulmonary arterial hypertension (PAH), echocardiography is frequently used to assess response to acute vasodilator therapy. We sought to evaluate whether echocardiography is sensitive enough to

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Pediatric Use of Inhaled Iloprost

Stephanie S. Handler, Steven H. Abman, Nidhy P. Varghese, D. Dunbar Ivy Medical College of Wisconsin and Children’s WIsconsin. University of Colorado School of Medicine and Children’s Hospital Colorado. Baylor College of Medicine and Texas Children’s Hospital.United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70115 AbstractAbstract Not Available CategoryMedical Therapy. Efficacy or Lack of Efficacy Age

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Postnatally induced TBX4 insufficiency confers pulmonary hypertension and impairs lung development in infant mice

Caroline F. Smith, Kathy L. Ding, Gregory J. Seedorf, Csaba Galambos, Steven H. AbmanUniversity of Colorado School of Medicine. United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04127-5 AbstractBackground: Genetic variants in T-box transcription factor 4 (TBX4) cause pulmonary hypertension (PH); however, there are diverse phenotypes with respect to the timing and severity of disease. Previous mouse studies

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Isolated pulmonary valve endocarditis in a 7-year-old Nigerian girl: a case report

Ayobami Oyetunji Alabi, Bukola Adetutu Sayomi, Olanike Taye Oladibu, Mayowa Mary Adetoye, Nicholas Aderinto, Adeseye Abiodun AkintundeLadoke Akintola University of Technology (LAUTECH) Teaching Hospital. Nigeria Journal of Medical Case ReportsJ Med Case Rep 2025; 19: DOI: 10.1186/s13256-025-05241-y AbstractBackground: Right-sided infective endocarditis is a rare clinical entity, with isolated pulmonary valve infective endocarditis being extremely uncommon. Infective endocarditis

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Deciphering epigenetic control of Notch signaling in persistent pulmonary hypertension of the newborn

Matthew D. Durbin, David G. Tingay, Kok Lim KuaIndiana University School of Medicine. Murdoch Children’s Research Institute and University of Melbourne.United States and Australia Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04234-3 AbstractAbstract Not Available CategoryClass I. Persistent Pulmonary Hypertension of the NewbornAnimal Models of Pulmonary Vascular Disease and TherapyVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseGenetic

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Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial

Dalia A. Gomaa, Sahar M. El‑Haggar, Mohamed R. El‑Shanshory, Osama El‑Razaky, Dalia R. El‑AffyTanta University. Egypt Paediatric DrugsPaediatr Drugs 2025; DOI: 10.1007/s40272-025-00701-w AbstractBackground: Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can be identified by measuring tricuspid regurgitant jet velocity (TRJV). We looked for the possible

Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial Read More »

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