Pediatric Pulmonary Vascular Disease

Systemic Sirolimus Therapy for Infants and Children With Pulmonary Vein Stenosis

Jay D. Patel, Michael Briones, Mansi Mandhani, Shannon Jones, Divya Suthar, Rosemary Gray, Joelle Pettus, Courtney McCraken, Amanda Thomas, Christopher J. PetitEmory University and Children’s Healthcare of AtlantaUnited States Journal of the American College of CardiologyJ Am Coll Cardiol 2021; 77: 2807-2818DOI: 10.1016/j.jacc.2021.04.013 AbstractBackground: Anatomic interventions for pulmonary vein stenosis (PVS) in infants and children have been […]

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The vascular phenotype of BPD: new basic science insights-new precision medicine approaches

Wojciech Durlak, Bernard ThébaudUniversity of Ottawa. Jagiellonian University Medical College. Poland and Canada Pediatric ResearchPediatr Res 2022; DOI: 10.1038/s41390-022-02428-7 AbstractBronchopulmonary dysplasia (BPD) is the most common complication of preterm birth. Up to 1/3 of children with BPD develop pulmonary hypertension (PH). PH increases mortality, the risk of adverse neurodevelopmental outcome and lacks effective treatment. Current vasodilator

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Primary pulmonary vein stenosis during infancy: state of the art review

David B. Frank, Philip T. Levy, Corey A. Stiver, Brian A. Boe, Christopher W. Baird, Ryan M. Callahan, Charles V. Smith, Rachel D. Vanderlaan, Carl H. BackesUniversity of Pennsylvania and Children’s Hospital of Philadelphia. Harvard University and Boston Children’s Hospital. Ohio State University and Nationwide Children’s Hospital. University of Washington and Seattle Children’s Research Institute.

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Pulmonary hypertension in extremely preterm infants: a call to standardize echocardiographic screening and follow-up policy

Sanne Arjaans, Elvira A. H. Zwart, Marc Roofthooft, Elisabeth M. W. Kooi, Arend F. Bos, Rolf M. F. BergerBeatrix Children’s Hospital, University Medical Center Groningen and University of GroningenNetherlands European Journal of PediatricsEur J Pediatr 2021; 180: 1855-1865DOI: 10.1007/s00431-021-03931-5 AbstractPulmonary hypertension (PH) is a frequent complication in extremely preterm born infants that seriously affects outcome. We

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Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management

Erika B. Rosenzweig, Steven H. Abman, Ian Adatia, Maurice Beghetti, Damien Bonnet, Sheila Haworth, D. Dunbar Ivy, Rolf M. F. BergerColumbia University and New York Presbyterian Hospital. University of Colorado and Children’s Hospital Colorado. Glenwood Children’s Heart Clinic. University Hospitals of Geneva and Lausanne. Hôpital Necker Enfants Malades, AP-HP, Université Paris Descartes. University College London.

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Pediatric Population Pharmacokinetic Modeling and Exposure-Response Analysis of Ambrisentan in Pulmonary Arterial Hypertension and Comparison With Adult Data

Malek Okour, Mita M. Thapar, Colm Farrell, Mary Ann Lukas, Maurice Beghetti, Misba BeeraheeGlaxo Smith Kline. ICON Clinical Research. University of Geneva and Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque Pédiatrique.United States, United Kingdom and Switzerland Journal of Clinical PharmacologyJ Clin Pharmacol 2022; DOI: 10.1002/jcph.2199 AbstractThis study aimed to develop a population pharmacokinetic (PK) model

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International practice heterogeneity in pre-transplant management of pulmonary hypertension related to pediatric left heart disease

Rachel K. Hopper, Oscar van der Have, Seth A. Hollander, Anne I. Dipchand, Valeria Perez de Sa, Jeffery A. Feinstein, Karin Tran-LundmarkStanford University and Lucille Packard Children’s Hospital. Lund University. Skane University Hospital. University of Toronto and the Hospital for Sick ChildrenUnited States, Sweden and Canada Pediatric TransplantationPediatr Transplant 2023; DOI: 10.1111/petr.14461 AbstractBackground: Elevated pulmonary vascular resistance

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Monitoring and evaluation of the surgical Potts shunt physiology using 4-dimensional flow magnetic resonance imaging

Michael Schafer, Benjamin S. Frank, R. Mark Grady, Pirooz Eghtesady, Max B. Mitchell, James Jaggers, D. Dunbar IvyWashington University and St. Louis Children’s Hospital. University of Colorado and Children’s Hospital Colorado.United States Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2022; 164: 331-341DOI: 10.1016/j.jtcvs.2021.11.025 AbstractObjective: The reversed Potts shunt is an increasingly applied mode of surgical

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Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension

Megan Griffiths, Jun Yang, Dhananjay Vaidya, Melanie Nies, Stephanie Brandal, D. Dunbar Ivy, Francis Hickey, Kristine Wolter-Warmerdam, Eric D. Austin, Mary Mullen, Michael W. Pauciulo, Katie A. Lutz, Erika B. Rosenzweig, Russel Hirsch, Delphine Yung, William C. Nichols, Allen D. EverettJohns Hopkins University. University of Colorado and Children’s Hospital Colorado. Vanderbilt University. Harvard University and

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Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension

Erika B. Rosenzweig, Angela Bates, Mary P. Mullen, Steven H. Abman, Eric D. Austin, Allen Everett, Jeffrey Fineman, Jeffrey Feinstein, Rachel K. Hopper, John P. Kinsella, Usha S. Krishnan, Minmin Lu, Kenneth D, Mandl, J. Usha Raj, Nidhy Varghese, Delphene Yung, Stephanie S. Handler, Lynn A. SleeperPediatric Pulmonary Hypertension NetworkUnited States and Canada Annals of

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