Pediatric Pulmonary Vascular Disease

Patent ductus arteriosus and the risk of bronchopulmonary dysplasia-associated pulmonary hypertension

Hythem Nawaytou, Nancy K. Hills, Ronald I. ClymanUniversity of California San Francisco.United States Pediatric ResearchPediatr Res 2023; DOI: 10.1038/s41390-023-02522-4 AbstractBackground: The aim of the study was to determine whether prolonged exposure to a moderate/large patent ductus arteriosus left-to-right shunt (PDA) increases the risk of late (beyond 36 weeks) pulmonary hypertension (BPD-PH) and pulmonary vascular disease (BPD-PVD) during […]

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Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience

David Edward Youssef, Stephanie S. Handler, Susan Marjorie Richards, Catherine Anne Sheppard, Jenna Smith, Kathryn Tillman, Matthew Pietrosanu, Edward Kirkpatrick, Angela Bates University of Alberta and Stollery Children’s Hospital. Medical College of Wisconsin.Canada and United States Frontiers in PediatricsFront Pediatr 2023; DOI: 10.3389/fped.2023.1055131 AbstractIntroduction: Phosphodiesterase type 5 (PDE5) inhibitors, with sildenafil the earliest among them, are widely used

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Sleep disordered breathing and its relation to stroke and pulmonary hypertension in children with sickle cell disease: a single-center cross-sectional study

Azza Tantawy, Nayera El‑Sherif, Sara Makkeyah, Nahed Salah Eldeen, Noura Bahaa El‑Din Farghal, Nanies Soliman, Fatma S. E. EbeidAin Shams University.Egypt Annals of HematologyAnn Hematol 2023; 102: 271-281DOI: 10.1007/s00277-023-05099-4 AbstractSleep disordered breathing (SDB) is a common underdiagnosed sequela of sickle cell disease (SCD) that has been linked to the frequency of vaso-occlusive crises. To determine the frequency of SDB in children with SCD and its association to SCD-related

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Population pharmacokinetics of riociguat in a pediatric population (aged ≥ 6 years) with pulmonary arterial hypertension

Stefan Willmann, Andrea Kerstin Keller, Michaela Meyer, Dorina van der Mey, Gagriela Wirsching, Yang Zhang, Henk-Jan Drenth, Anne Keunecke, Esmée Vendel, Soundos SalehBayer AG. LAP&P Consultants.Germany Pediatric PulmonologyPediatr Pulmonol 2023; 58: 908-917DOI: 10.1002/ppul.26277 AbstractBackground: The PATENT-CHILD study investigated riociguat in children aged ≥ 6 to <18 years with pulmonary arterial hypertension (PAH) treated with tablets or an

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A North American, single-center experience implanting fenestrated atrial devices and atrial flow regulators into a heterogeneous group of pediatric pulmonary hypertension patients

David Edward Youssef, Konstantin Averin, Susan Richards, Catherine Sheppard, Cameron Seaman, Matthew Pietrosanu and Angela BatesUniversity of Alberta and Stollery Children’s Hospital. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.Canada and United States Frontiers in PediatricsFront Pediatr 2023; 11: DOI: 10.3389/fped.2023.1073336 AbstractIntroduction: The clinical deterioration commonly experienced by pediatric patients with pulmonary arterial hypertension (PAH) has

A North American, single-center experience implanting fenestrated atrial devices and atrial flow regulators into a heterogeneous group of pediatric pulmonary hypertension patients Read More »

Quantifying side effects and caregiver burdens of pediatric pulmonary hypertension therapies

Erik J. Nelson, Ella Cook, Samara Nelson, Rebecca Brown, Megan Pierce, Ashley Bangerter Seelos, Heather Stickle and Michael JohansenBrigham Young University. Utah State University. Indiana University School of Medicine. United States BioMed Central PediatricsBMC Pediatr 2023; 23: DOI: 10.1186/s12887-023-03860-2 AbstractBackground and objectives: Pulmonary hypertension (PH) is a rare, but serious disease among children. However, PH has been

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Pulmonary hypertension screening in children with sickle cell disease

Kok Hoe Chan, Syeda Hiba Rizvi, Wilfredo De Jesus-Rojas, James M. Stark, Ricardo A. Mosquera, Adrianna Carolina Prada-Ruiz, Traci Gonzalez, Deborah L. Brown, Neethu M. Menon, Trinh T. Nguyen, Cindy K. Jon, Aravind YadavUniversity of Texas Health Science Center at Houston. Ponce Health Science University and Ponce Research Institute. Baylor College of Medicine.United States Pediatric

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Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension

Paul J. Critser, Nara S. Higano, Jean A. Tkach, Emilia S. Olson, David R. Spielberg, Paul S. Kingma, Robert J, Fleck, Sean M. Lang, Ryan A. Moore, Michael D. Taylor, Jason C. WoodsUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center. Baylor College of Medicine and Texas Children’s Hospital.United States American Journal of Respiratory and

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Recovery of right ventricular function after bilateral lung transplantation for pediatric pulmonary hypertension

Paul J. Critser, Debra Boyer, Gary A. Visner, Shane L. Collins, Mary P. MullenHarvard University and Boston Children’s Hospital.United States Pediatric TransplantationPediatr Transplant 2022; 26: e14236DOI: 10.1111/petr.14236 AbstractBackground: Lung transplantation is a therapeutic option for end-stage pediatric pulmonary hypertension (PH). Right ventricular (RV) recovery post-lung transplant in children with PH has not been well-described, and questions persist

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Echocardiography-derived septal curvature correlated with invasive hemodynamics in pediatric pulmonary hypertension

Paul J. Critser, Patrick D. Evers, Kristin Schneider, Russel Hirsch, Michael D. Taylor, Jason C. Woods, Sean M. LangUniversity of Cincinnati and Cincinnati Children’s Hospital Medical Center.United States Journal of EchocardiographyJ Echocardiogr 2022; 20: 24-32DOI: 10.1007/s12574-021-00545-6 AbstractBackground: Right ventricular function and afterload are associated with clinical outcomes in pulmonary hypertension (PH). MRI-derived interventricular septal curvature has been

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